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Impact of SMTP Targeting Plasminogen and Soluble Epoxide Hydrolase on Thrombolysis, Inflammation, and Ischemic Stroke

International journal of molecular sciences, 2021-01, Vol.22 (2), p.954

2021

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Potent Efficacy of 3-Amino-4-hydroxy Benzoic Acid, a Small Molecule Having Anti-fibrotic Activity, in a Mouse Model of Non-alcoholic Steatohepatitis

Biological and Pharmaceutical Bulletin, 2024/02/16, Vol.47(2), pp.434-442

2024

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Identification of aminobenzoic acids as selective inhibitors of the N-terminal phosphatase of soluble epoxide hydrolase

Bioscience, biotechnology, and biochemistry, 2023-04, Vol.87 (5), p.511-515

2023

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Effect of SMTP-7 on Cisplatin-Induced Nephrotoxicity in Mice

Biological and Pharmaceutical Bulletin, 2022/12/01, Vol.45(12), pp.1832-1838

2022

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Potent efficacy of Stachybotrys microspora triprenyl phenol-7, a small molecule having anti-inflammatory and antioxidant activities, in a mouse model of acute kidney injury

European journal of pharmacology, 2021-11, Vol.910, p.174496, Article 174496

2021

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Kurozu melanoidin, a novel oligoglucan-melanoidin complex from Japanese black vinegar, suppresses adipogenesis in vitro

Journal of functional foods, 2020-09, Vol.72, p.104046, Article 104046

2020

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SMTP-44D Exerts Antioxidant and Anti-Inflammatory Effects through Its Soluble Epoxide Hydrolase Inhibitory Action in Immortalized Mouse Schwann Cells upon High Glucose Treatment

International journal of molecular sciences, 2022-05, Vol.23 (9), p.5187

2022

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Evaluation of the effects of a new series of SMTPs in the acetic acid-induced embolic cerebral infarct mouse model

European journal of pharmacology, 2018-01, Vol.818, p.221-227

2018

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Unsaturated fatty acids enhance the fibrinolytic activity of subtilisin NAT (nattokinase)

Journal of food biochemistry, 2020-08, Vol.44 (8), p.e13326-n/a

2020

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Structure–activity relationship of cyclic pentapeptide malformins as fibrinolysis enhancers

Bioorganic & medicinal chemistry letters, 2016-11, Vol.26 (21), p.5267-5271

2016

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A first‐in‐human study of the anti‐inflammatory profibrinolytic TMS‐007, an SMTP family triprenyl phenol

British journal of clinical pharmacology, 2023-06, Vol.89 (6), p.1809-1819

2023

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SMTP-44D Inhibits Atherosclerotic Plaque Formation in Apolipoprotein-E Null Mice Partly by Suppressing the AGEs-RAGE Axis

International journal of molecular sciences, 2023-03, Vol.24 (7), p.6505

2023

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N-Substituted amino acid inhibitors of the phosphatase domain of the soluble epoxide hydrolase

Biochemical and biophysical research communications, 2019-07, Vol.515 (1), p.248-253

2019

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Neuroprotective effects of SMTP‐44D in mice stroke model in relation to neurovascular unit and trophic coupling

Journal of neuroscience research, 2018-12, Vol.96 (12), p.1887-1899

2018

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Anti-angiogenic activity of a novel angiostatin-like plasminogen fragment produced by a bacterial metalloproteinase

Heliyon, 2024-08, Vol.10 (15), p.e35232, Article e35232

2024

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SMTP-7, a new thrombolytic agent, decreases hemorrhagic transformation after transient middle cerebral artery occlusion under warfarin anticoagulation in mice

Brain research, 2014-08, Vol.1578, p.38-48

2014

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SMTP-7, a Novel Small-Molecule Thrombolytic for Ischemic Stroke: A Study in Rodents and Primates

Journal of cerebral blood flow and metabolism, 2014-02, Vol.34 (2), p.235-241

2014

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Altered Gene Expression in an Embolic Stroke Model After Thrombolysis With Tissue Plasminogen Activator and Stachybotrys microspora Triprenyl Phenol-7

Journal of Pharmacological Sciences, 2014/05/20, Vol.125(1), pp.99-106

2014

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Soluble epoxide hydrolase maintains steady-state lipid turnover linked with autocrine signaling in peritoneal macrophages

iScience, 2023-08, Vol.26 (8), p.107465-107465, Article 107465

2023

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Confirmation of the absolute configuration of Stachybotrin C using single-crystal X-ray diffraction analysis of its 4-bromobenzyl ether derivative

Journal of antibiotics, 2018-06, Vol.71 (6), p.584-591

2018

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Involvement of RSK1 activation in malformin-enhanced cellular fibrinolytic activity

Scientific reports, 2018-04, Vol.8 (1), p.5472-11, Article 5472

2018

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Distinct Effects of Tissue-Type Plasminogen Activator and SMTP-7 on Cerebrovascular Inflammation Following Thrombolytic Reperfusion

Stroke (1970), 2011-04, Vol.42 (4), p.1097-1104

2011

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A Novel Embolic Model of Cerebral Infarction and Evaluation of Stachybotrys microspora Triprenyl Phenol-7 (SMTP-7), a Novel Fungal Triprenyl Phenol Metabolite

Journal of Pharmacological Sciences, 2010, Vol.114(1), pp.41-49

2010

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Amine-Regulated pri-SMTP Oxidation in SMTP Biosynthesis in Stachybotrys: Possible Implication in Nitrogen Acquisition

Journal of fungi (Basel), 2022-09, Vol.8 (9), p.975

2022

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SMTP‐44D improves diabetic neuropathy symptoms in mice through its antioxidant and anti‐inflammatory activities

Pharmacology research & perspectives, 2020-12, Vol.8 (6), p.e00648-n/a

2020

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Impact of SMTP Targeting Plasminogen and Soluble Epoxide Hydrolase on Thrombolysis, Inflammation, and Ischemic Stroke

Potent Efficacy of 3-Amino-4-hydroxy Benzoic Acid, a Small Molecule Having Anti-fibrotic Activity, in a Mouse Model of Non-alcoholic Steatohepatitis

Identification of aminobenzoic acids as selective inhibitors of the N-terminal phosphatase of soluble epoxide hydrolase

Effect of SMTP-7 on Cisplatin-Induced Nephrotoxicity in Mice

Potent efficacy of Stachybotrys microspora triprenyl phenol-7, a small molecule having anti-inflammatory and antioxidant activities, in a mouse model of acute kidney injury

Kurozu melanoidin, a novel oligoglucan-melanoidin complex from Japanese black vinegar, suppresses adipogenesis in vitro

SMTP-44D Exerts Antioxidant and Anti-Inflammatory Effects through Its Soluble Epoxide Hydrolase Inhibitory Action in Immortalized Mouse Schwann Cells upon High Glucose Treatment

Evaluation of the effects of a new series of SMTPs in the acetic acid-induced embolic cerebral infarct mouse model

Unsaturated fatty acids enhance the fibrinolytic activity of subtilisin NAT (nattokinase)

Structure–activity relationship of cyclic pentapeptide malformins as fibrinolysis enhancers

A first‐in‐human study of the anti‐inflammatory profibrinolytic TMS‐007, an SMTP family triprenyl phenol

SMTP-44D Inhibits Atherosclerotic Plaque Formation in Apolipoprotein-E Null Mice Partly by Suppressing the AGEs-RAGE Axis

N-Substituted amino acid inhibitors of the phosphatase domain of the soluble epoxide hydrolase

Neuroprotective effects of SMTP‐44D in mice stroke model in relation to neurovascular unit and trophic coupling

Anti-angiogenic activity of a novel angiostatin-like plasminogen fragment produced by a bacterial metalloproteinase

SMTP-7, a new thrombolytic agent, decreases hemorrhagic transformation after transient middle cerebral artery occlusion under warfarin anticoagulation in mice

SMTP-7, a Novel Small-Molecule Thrombolytic for Ischemic Stroke: A Study in Rodents and Primates

Altered Gene Expression in an Embolic Stroke Model After Thrombolysis With Tissue Plasminogen Activator and Stachybotrys microspora Triprenyl Phenol-7

Soluble epoxide hydrolase maintains steady-state lipid turnover linked with autocrine signaling in peritoneal macrophages

Confirmation of the absolute configuration of Stachybotrin C using single-crystal X-ray diffraction analysis of its 4-bromobenzyl ether derivative

Involvement of RSK1 activation in malformin-enhanced cellular fibrinolytic activity

Distinct Effects of Tissue-Type Plasminogen Activator and SMTP-7 on Cerebrovascular Inflammation Following Thrombolytic Reperfusion

A Novel Embolic Model of Cerebral Infarction and Evaluation of Stachybotrys microspora Triprenyl Phenol-7 (SMTP-7), a Novel Fungal Triprenyl Phenol Metabolite

Amine-Regulated pri-SMTP Oxidation in SMTP Biosynthesis in Stachybotrys: Possible Implication in Nitrogen Acquisition

SMTP‐44D improves diabetic neuropathy symptoms in mice through its antioxidant and anti‐inflammatory activities

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