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Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile

The Journal of pharmacology and experimental therapeutics, 1996-05, Vol.277 (2), p.968

1996

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Effects of the selective 5-HT2A receptor antagonist MDL 100,907 on MDMA-induced locomotor stimulation in rats

Neuropsychopharmacology (New York, N.Y.), 1996-08, Vol.15 (2), p.116-124

1996

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The role of 5-HT2A receptors in antipsychotic activity

Life sciences (1973), 1995-05, Vol.56 (25), p.2209-2222

1995

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Effects of the CRF(1) receptor antagonist, CP 154,526, in the separation-induced vocalization anxiolytic test in rat pups

Neuropharmacology, 2000-06, Vol.39 (8), p.1357-1367

2000

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Reversal of amphetamine-induced behaviours by MDL 100,907, a selective 5-HT2A antagonist

Behavioural brain research, 1996, Vol.73 (1-2), p.163-167

1996

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Preclinical Antipsychotic Activity of The Selective 5-HT2 Antagonist, MDL100,907

Neuropsychopharmacology (New York, N.Y.), 2003-07, Vol.11 (4), p.282-282

2003

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Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist

European journal of pharmacology, 1997-04, Vol.323 (2), p.181-192

1997

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NMDA receptor complex antagonists have potential anxiolytic effects as measured with separation-induced ultrasonic vocalizations

European journal of pharmacology, 1991-02, Vol.193 (3), p.283-292

1991

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Neurotoxicity of MDMA: Neurochemical Effects

Annals of the New York Academy of Sciences, 1990-01, Vol.600 (1), p.665-680

1990

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Spinalization unmasks clonidine's alpha 1-adrenergic mediated excitation of the flexor reflex in rats

The Journal of neuroscience, 1985-06, Vol.5 (6), p.1583-1590

1985

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5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents

Journal of medicinal chemistry, 1994-01, Vol.37 (1), p.125-132

1994

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3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-methyl-D-aspartic acid receptor associated glycine binding site

Journal of medicinal chemistry, 1992-05, Vol.35 (10), p.1791-1799

1992

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Anxiolytic effects of buspirone and gepirone in the fear-potentiated startle paradigm

Psychopharmacologia, 1988-01, Vol.94 (1), p.8-13

1988

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Serotonin does not mediate anxiolytic effects of buspirone in the fear-potentiated startle paradigm: comparison with 8-OH-DPAT and ipsapirone

Psychopharmacologia, 1988-01, Vol.94 (1), p.14-20

1988

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Cyclic Nitrone Free Radical Traps: Isolation, Identification, and Synthesis of 3,3-Dimethyl-3,4-dihydroisoquinolin-4-ol N-Oxide, a Metabolite with Reduced Side Effects

Journal of medicinal chemistry, 1996-12, Vol.39 (25), p.4997-5004

1996

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Effects of the serotonin releasers 3,4-methylenedioxymethamphetamine (MDMA), 4-chloroamphetamine (PCA) and fenfluramine on acoustic and tactile startle reflexes in rats

The Journal of pharmacology and experimental therapeutics, 1992-01, Vol.260 (1), p.78

1992

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The peripheral NK-1/NK-2 receptor antagonist MDL 105,172A inhibits tachykinin-mediated respiratory effects in guinea-pigs

Journal of autonomic pharmacology, 1997-04, Vol.17 (2), p.109-119

1997

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Preclinical characterization of MDL 27,192 as a potential broad spectrum anticonvulsant agent with neuroprotective properties

Epilepsy research, 1997-04, Vol.27 (1), p.41-54

1997

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MDL 26,479: a potential cognition enhancer with benzodiazepine inverse agonist‐like properties

British journal of pharmacology, 1992-09, Vol.107 (1), p.78-86

1992

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Contribution of serotonin neurotoxins to understanding psychiatric disorders: the role of 5-HT2, receptors in schizophrenia and antipsychotic activity

International clinical psychopharmacology, 1993-11, Vol.8 Suppl 2, p.25-32

1993

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Central noradrenergic involvement in yohimbine excitation of acoustic startle: Effects of DSP4 and 6-OHDA

Brain research, 1985-03, Vol.330 (1), p.31-41

1985

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Effects of the phosphodiesterase inhibitor rolipram on the acoustic startle response in rats

Psychopharmacologia, 1991-01, Vol.105 (1), p.27-36

1991

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Differential blockade of early and late components of acoustic startle following intrathecal infusion of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) or d,l-2-amino-5-phosphonovaleric acid (AP-5)

Brain research, 1990-06, Vol.520 (1), p.240-246

1990

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Habituation and Sensitization of Startle Reflexes Elicited Electrically from the Brainstem

Science (American Association for the Advancement of Science), 1982-11, Vol.218 (4573), p.688-690

1982

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MDL 27,531 selectively reverses strychnine‐induced seizures in mice

British journal of pharmacology, 1992-08, Vol.106 (4), p.910-916

1992

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Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile

Effects of the selective 5-HT2A receptor antagonist MDL 100,907 on MDMA-induced locomotor stimulation in rats

The role of 5-HT2A receptors in antipsychotic activity

Effects of the CRF(1) receptor antagonist, CP 154,526, in the separation-induced vocalization anxiolytic test in rat pups

Reversal of amphetamine-induced behaviours by MDL 100,907, a selective 5-HT2A antagonist

Preclinical Antipsychotic Activity of The Selective 5-HT2 Antagonist, MDL100,907

Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist

NMDA receptor complex antagonists have potential anxiolytic effects as measured with separation-induced ultrasonic vocalizations

Neurotoxicity of MDMA: Neurochemical Effects

Spinalization unmasks clonidine's alpha 1-adrenergic mediated excitation of the flexor reflex in rats

5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents

3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-methyl-D-aspartic acid receptor associated glycine binding site

Anxiolytic effects of buspirone and gepirone in the fear-potentiated startle paradigm

Serotonin does not mediate anxiolytic effects of buspirone in the fear-potentiated startle paradigm: comparison with 8-OH-DPAT and ipsapirone

Cyclic Nitrone Free Radical Traps: Isolation, Identification, and Synthesis of 3,3-Dimethyl-3,4-dihydroisoquinolin-4-ol N-Oxide, a Metabolite with Reduced Side Effects

Effects of the serotonin releasers 3,4-methylenedioxymethamphetamine (MDMA), 4-chloroamphetamine (PCA) and fenfluramine on acoustic and tactile startle reflexes in rats

The peripheral NK-1/NK-2 receptor antagonist MDL 105,172A inhibits tachykinin-mediated respiratory effects in guinea-pigs

Preclinical characterization of MDL 27,192 as a potential broad spectrum anticonvulsant agent with neuroprotective properties

MDL 26,479: a potential cognition enhancer with benzodiazepine inverse agonist‐like properties

Contribution of serotonin neurotoxins to understanding psychiatric disorders: the role of 5-HT2, receptors in schizophrenia and antipsychotic activity

Central noradrenergic involvement in yohimbine excitation of acoustic startle: Effects of DSP4 and 6-OHDA

Effects of the phosphodiesterase inhibitor rolipram on the acoustic startle response in rats

Differential blockade of early and late components of acoustic startle following intrathecal infusion of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) or d,l-2-amino-5-phosphonovaleric acid (AP-5)

Habituation and Sensitization of Startle Reflexes Elicited Electrically from the Brainstem

MDL 27,531 selectively reverses strychnine‐induced seizures in mice

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