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The path to the clinic: a comprehensive review on direct KRASG12C inhibitors

Journal of experimental & clinical cancer research, 2022-01, Vol.41 (1), p.1-27, Article 27

2022

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The RAS-Effector Interaction as a Drug Target

Cancer research (Chicago, Ill.), 2017-01, Vol.77 (2), p.221-226

2017

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Exploiting RAS Nucleotide Cycling as a Strategy for Drugging RAS-Driven Cancers

International journal of molecular sciences, 2019-12, Vol.21 (1), p.141

2019

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New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres

PloS one, 2017-07, Vol.12 (7), p.e0181241-e0181241

2017

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Synthesis and biological evaluation of certain hydrazonoindolin-2-one derivatives as new potent anti-proliferative agents

Journal of enzyme inhibition and medicinal chemistry, 2018-01, Vol.33 (1), p.867-878

2018

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Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer

Journal of experimental & clinical cancer research, 2019-08, Vol.38 (1), p.312-312, Article 312

2019

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Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics

PloS one, 2016-10, Vol.11 (10), p.e0163615-e0163615

2016

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Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G

Molecular cancer therapeutics, 2009-12, Vol.8 (12), p.3331-3340

2009

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Phosphodiesterase 10A (PDE10A) as a novel target to suppress β-catenin and RAS signaling in epithelial ovarian cancer

Journal of ovarian research, 2022-11, Vol.15 (1), p.120-17, Article 120

2022

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Inhibition of the Lysophosphatidylinositol Transporter ABCC1 Reduces Prostate Cancer Cell Growth and Sensitizes to Chemotherapy

Cancers, 2020-07, Vol.12 (8), p.2022

2020

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Novel Non-Cyclooxygenase Inhibitory Derivative of Sulindac Inhibits Breast Cancer Cell Growth In Vitro and Reduces Mammary Tumorigenesis in Rats

Cancers, 2023-01, Vol.15 (3), p.646

2023

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Enhancing anticancer activity of checkpoint immunotherapy by targeting RAS

MedComm (2020), 2020-09, Vol.1 (2), p.121-128

2020

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PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/β-catenin transcription, cancer cell growth, and tumor immunity

Drug discovery today, 2020-08, Vol.25 (8), p.1521-1527

2020

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From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity

Journal of medicinal chemistry, 2021-04, Vol.64 (8), p.4462-4477

2021

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Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling

Molecular cancer therapeutics, 2013-09, Vol.12 (9), p.1848-1859

2013

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Novel Celecoxib Derivative, RF26, Blocks Colon Cancer Cell Growth by Inhibiting PDE5, Activating cGMP/PKG Signaling, and Suppressing β-catenin-dependent Transcription

Anti-cancer agents in medicinal chemistry, 2024-09, Vol.24

2024

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β-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKG

Oncotarget, 2016-02, Vol.7 (5), p.5353-5365

2016

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NSAIDs: Old Drugs Reveal New Anticancer Targets

Pharmaceuticals, 2010-05, Vol.3 (5), p.1652-1667

2010

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Insulin Enhances Growth Hormone Induction of the MEK/ERK Signaling Pathway

The Journal of biological chemistry, 2006-01, Vol.281 (2), p.982-992

2006

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Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin-mediated transcription in human breast tumor cells

Cancer prevention research (Philadelphia, Pa.), 2011-08, Vol.4 (8), p.1275-1284

2011

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Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling

Drug design, development and therapy, 2017-01, Vol.11, p.2333-2346

2017

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New Isatin-Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity

Drug design, development and therapy, 2020-02, Vol.14, p.483-495

2020

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Metabolism and growth inhibitory activity of cranberry derived flavonoids in bladder cancer cells

Food & function, 2016-09, Vol.7 (9), p.412-419

2016

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Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity

European journal of medicinal chemistry, 2013, Vol.70, p.273-279

2013

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Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling

Oncotarget, 2017-09, Vol.8 (41), p.69264-69280

2017

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The path to the clinic: a comprehensive review on direct KRASG12C inhibitors

The RAS-Effector Interaction as a Drug Target

Exploiting RAS Nucleotide Cycling as a Strategy for Drugging RAS-Driven Cancers

New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres

Synthesis and biological evaluation of certain hydrazonoindolin-2-one derivatives as new potent anti-proliferative agents

Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer

Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics

Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G

Phosphodiesterase 10A (PDE10A) as a novel target to suppress β-catenin and RAS signaling in epithelial ovarian cancer

Inhibition of the Lysophosphatidylinositol Transporter ABCC1 Reduces Prostate Cancer Cell Growth and Sensitizes to Chemotherapy

Novel Non-Cyclooxygenase Inhibitory Derivative of Sulindac Inhibits Breast Cancer Cell Growth In Vitro and Reduces Mammary Tumorigenesis in Rats

Enhancing anticancer activity of checkpoint immunotherapy by targeting RAS

PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/β-catenin transcription, cancer cell growth, and tumor immunity

From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity

Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling

Novel Celecoxib Derivative, RF26, Blocks Colon Cancer Cell Growth by Inhibiting PDE5, Activating cGMP/PKG Signaling, and Suppressing β-catenin-dependent Transcription

β-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKG

NSAIDs: Old Drugs Reveal New Anticancer Targets

Insulin Enhances Growth Hormone Induction of the MEK/ERK Signaling Pathway

Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin-mediated transcription in human breast tumor cells

Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling

New Isatin-Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity

Metabolism and growth inhibitory activity of cranberry derived flavonoids in bladder cancer cells

Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity

Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling

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