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Identification of small molecule inhibitors of the hepatitis C virus RNA-dependent RNA polymerase from a pyrrolidine combinatorial mixture

Bioorganic & medicinal chemistry letters, 2005-03, Vol.15 (6), p.1553-1556

2005

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Identification of a Pharmacophore for Thrombopoietic Activity of Small, Non-Peptidyl Molecules. 1. Discovery and Optimization of Salicylaldehyde Thiosemicarbazone Thrombopoietin Mimics

Journal of medicinal chemistry, 2002-08, Vol.45 (17), p.3573-3575

2002

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3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, Potent Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase

Journal of medicinal chemistry, 2006-02, Vol.49 (3), p.971-983

2006

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Identification of a Pharmacophore for Thrombopoietic Activity of Small, Non-Peptidyl Molecules. 2. Rational Design of Naphtho[1,2-d]imidazole Thrombopoietin Mimics

Journal of medicinal chemistry, 2002-08, Vol.45 (17), p.3576-3578

2002

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Identification and Biological Characterization of Heterocyclic Inhibitors of the Hepatitis C Virus RNA-dependent RNA Polymerase

The Journal of biological chemistry, 2002-10, Vol.277 (41), p.38322-38327

2002

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Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (15), p.4350-4353

2009

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Selective Binding and Oligomerization of the Murine Granulocyte Colony-stimulating Factor Receptor by a Low Molecular Weight, Nonpeptidyl Ligand

The Journal of biological chemistry, 2003-03, Vol.278 (11), p.9426-9434

2003

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Antagonists of the Calcium Receptor I. Amino Alcohol-Based Parathyroid Hormone Secretagogues

Journal of medicinal chemistry, 2009-07, Vol.52 (13), p.3982-3993

2009

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Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (15), p.4354-4358

2009

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Nonpeptidic urotensin‐II receptor antagonists I: in vitro pharmacological characterization of SB‐706375

British journal of pharmacology, 2005-07, Vol.145 (5), p.620-635

2005

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New benzimidazoles as thrombopoietin receptor agonists

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (5), p.1212-1216

2006

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Urotensin-II receptor antagonists: Synthesis and SAR of N-cyclic azaalkyl benzamides

Bioorganic & medicinal chemistry letters, 2008-07, Vol.18 (14), p.3950-3954

2008

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Aminoalkoxybenzyl pyrrolidines as novel human urotensin-II receptor antagonists

Bioorganic & medicinal chemistry letters, 2005-07, Vol.15 (13), p.3229-3232

2005

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Discovery of potent and selective phenylalanine derived CCR3 receptor antagonists. Part 2

Bioorganic & medicinal chemistry letters, 2001-06, Vol.11 (11), p.1445-1450

2001

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Preclinical pharmacokinetics and interspecies scaling of a novel vitronectin receptor antagonist

Drug metabolism and disposition, 1999-11, Vol.27 (11), p.1232

1999

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Discovery of potent and selective phenylalanine derived CCR3 antagonists. Part 1

Bioorganic & medicinal chemistry letters, 2001-06, Vol.11 (11), p.1441-1444

2001

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Discovery of Potent Nonpeptide Vitronectin Receptor (αVβ3) Antagonists

Journal of medicinal chemistry, 1997-07, Vol.40 (15), p.2289-2292

1997

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1-(Carboxybenzyl)imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists

Journal of medicinal chemistry, 1991-04, Vol.34 (4), p.1514-1517

1991

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Metal mediated protease inhibition: design and synthesis of inhibitors of the human cytomegalovirus (hCMV) protease

Bioorganic & medicinal chemistry letters, 2000-10, Vol.10 (20), p.2279-2282

2000

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Potent nonpeptide angiotensin II receptor antagonists. 2. 1-(Carboxybenzyl)imidazole-5-acrylic acids

Journal of medicinal chemistry, 1993-06, Vol.36 (13), p.1880-1892

1993

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Enantiospecific synthesis of SB 214857, a potent, orally active, nonpeptide fibrinogen receptor antagonist

Tetrahedron letters, 1995-12, Vol.36 (52), p.9433-9436

1995

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Synthesis of ( E)-olefin dipeptide isosteres

Tetrahedron letters, 1994-08, Vol.35 (33), p.5985-5988

1994

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Potent non-peptide fibrinogen receptor antagonists which present an alternative pharmacophore

Journal of medicinal chemistry, 1995-01, Vol.38 (1), p.9-12

1995

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Hydrazinonaphthalene and Azonaphthalene Thrombopoietin Mimics Are Nonpeptidyl Promoters of Megakaryocytopoiesis

Journal of medicinal chemistry, 2001-10, Vol.44 (22), p.3730-3745

2001

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Identification of small molecule inhibitors of the hepatitis C virus RNA-dependent RNA polymerase from a pyrrolidine combinatorial mixture

Identification of a Pharmacophore for Thrombopoietic Activity of Small, Non-Peptidyl Molecules. 1. Discovery and Optimization of Salicylaldehyde Thiosemicarbazone Thrombopoietin Mimics

3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, Potent Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase

Identification of 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a Novel Inhibitor of AKT Kinase

Identification of a Pharmacophore for Thrombopoietic Activity of Small, Non-Peptidyl Molecules. 2. Rational Design of Naphtho[1,2-d]imidazole Thrombopoietin Mimics

Identification and Biological Characterization of Heterocyclic Inhibitors of the Hepatitis C Virus RNA-dependent RNA Polymerase

Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase

Selective Binding and Oligomerization of the Murine Granulocyte Colony-stimulating Factor Receptor by a Low Molecular Weight, Nonpeptidyl Ligand

Antagonists of the Calcium Receptor I. Amino Alcohol-Based Parathyroid Hormone Secretagogues

Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors

Nonpeptidic urotensin‐II receptor antagonists I: in vitro pharmacological characterization of SB‐706375

New benzimidazoles as thrombopoietin receptor agonists

Urotensin-II receptor antagonists: Synthesis and SAR of N-cyclic azaalkyl benzamides

Aminoalkoxybenzyl pyrrolidines as novel human urotensin-II receptor antagonists

Discovery of potent and selective phenylalanine derived CCR3 receptor antagonists. Part 2

Preclinical pharmacokinetics and interspecies scaling of a novel vitronectin receptor antagonist

Discovery of potent and selective phenylalanine derived CCR3 antagonists. Part 1

Discovery of Potent Nonpeptide Vitronectin Receptor (αVβ3) Antagonists

1-(Carboxybenzyl)imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists

Metal mediated protease inhibition: design and synthesis of inhibitors of the human cytomegalovirus (hCMV) protease

Potent nonpeptide angiotensin II receptor antagonists. 2. 1-(Carboxybenzyl)imidazole-5-acrylic acids

Enantiospecific synthesis of SB 214857, a potent, orally active, nonpeptide fibrinogen receptor antagonist

Synthesis of ( E)-olefin dipeptide isosteres

Potent non-peptide fibrinogen receptor antagonists which present an alternative pharmacophore

Hydrazinonaphthalene and Azonaphthalene Thrombopoietin Mimics Are Nonpeptidyl Promoters of Megakaryocytopoiesis

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