UB Paderborn / Katalog / Suche / in CDI

1 – 25 von 238

Sortiert nach

Physiologically Based Pharmacokinetic Modeling and Allometric Scaling in Pediatric Drug Development: Where Do We Draw the Line?

Journal of clinical pharmacology, 2021-06, Vol.61 (S1), p.S83-S93

2021

Link zum Volltext

Verfügbarkeit prüfen

Impact of Disease on Plasma and Lung Exposure of Chloroquine, Hydroxychloroquine and Azithromycin: Application of PBPK Modeling

Clinical pharmacology and therapeutics, 2020-11, Vol.108 (5), p.976-984

2020

Link zum Volltext

Verfügbarkeit prüfen

In vitro to in vivo extrapolation for high throughput prioritization and decision making

Toxicology in vitro, 2018-03, Vol.47, p.213-227

2018

Link zum Volltext

Verfügbarkeit prüfen

PBPK modeling to predict drug‐drug interactions of ivosidenib as a perpetrator in cancer patients and qualification of the Simcyp platform for CYP3A4 induction

CPT: pharmacometrics and systems pharmacology, 2021-06, Vol.10 (6), p.577-588

2021

Link zum Volltext

Verfügbarkeit prüfen

Drug Dosing in Pregnant Women: Challenges and Opportunities in Using Physiologically Based Pharmacokinetic Modeling and Simulations

CPT: pharmacometrics and systems pharmacology, 2018-02, Vol.7 (2), p.103-110

2018

Link zum Volltext

Verfügbarkeit prüfen

Utility of Oatp1a/1b-knockout and OATP1B1/3-humanized mice in the study of OATP-mediated pharmacokinetics and tissue distribution: case studies with pravastatin, atorvastatin, simvastatin, and carboxydichlorofluorescein

Drug metabolism and disposition, 2014-01, Vol.42 (1), p.182

2014

Link zum Volltext

Verfügbarkeit prüfen

Physiologically‐based pharmacokinetic modeling of the drug–drug interaction between ivacaftor and lefamulin in cystic fibrosis patients

CPT: pharmacometrics and systems pharmacology, 2024-04, Vol.13 (4), p.589-598

2024

Link zum Volltext

Verfügbarkeit prüfen

Estimation of an Appropriate Dose of Trazodone for Pediatric Insomnia and the Potential for a Trazodone–Atomoxetine Interaction

CPT: pharmacometrics and systems pharmacology, 2020-02, Vol.9 (2), p.77-86

2020

Link zum Volltext

Verfügbarkeit prüfen

Metformin's Intrinsic Blood-to-Plasma Partition Ratio (B/P): Reconciling the Perceived High In Vivo B/P > 10 with the In Vitro Equilibrium Value of Unity

The Journal of pharmacology and experimental therapeutics, 2015-08, Vol.354 (2), p.225

2015

Link zum Volltext

Verfügbarkeit prüfen

Pharmacometrics in pregnancy: An unmet need

Annual review of pharmacology and toxicology, 2014-01, Vol.54 (1), p.53-69

2014

Link zum Volltext

Verfügbarkeit prüfen

Clinical pharmacokinetics of leriglitazone and a translational approach using PBPK modeling to guide the selection of the starting dose in children

CPT: pharmacometrics and systems pharmacology, 2024-06, Vol.13 (6), p.982-993

2024

Link zum Volltext

Verfügbarkeit prüfen

Clinical CYP3A inhibitor alternatives to ketoconazole, clarithromycin and itraconazole, are not transported into the liver by hepatic organic anion transporting polypeptides and organic cation transporter 1

Drug metabolism and disposition, 2014-11, Vol.42 (11), p.1780

2014

Link zum Volltext

Verfügbarkeit prüfen

Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19

British journal of clinical pharmacology, 2014-03, Vol.77 (3), p.554-570

2014

Link zum Volltext

Verfügbarkeit prüfen

Investigational small-molecule drug selectively suppresses constitutive CYP2B6 activity at the gene transcription level: physiologically based pharmacokinetic model assessment of clinical drug interaction risk

Drug metabolism and disposition, 2014-06, Vol.42 (6), p.1008

2014

Link zum Volltext

Verfügbarkeit prüfen

Prediction of CYP‐mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator

CPT: pharmacometrics and systems pharmacology, 2022-07, Vol.11 (7), p.822-832

2022

Link zum Volltext

Verfügbarkeit prüfen

Physiologically based pharmacokinetic model predictions of ivosidenib (AG-120) as a victim and perpetrator of drug–drug interactions

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S70-S70

2019

Link zum Volltext

Verfügbarkeit prüfen

Estimation of brain receptor occupancy for trazodone immediate release and once a day formulations

Clinical and translational science, 2022-06, Vol.15 (6), p.1417-1429

2022

Link zum Volltext

Verfügbarkeit prüfen

Evaluation of Maternal Drug Exposure Following the Administration of Antenatal Corticosteroids During Late Pregnancy Using Physiologically‐Based Pharmacokinetic Modeling

Clinical pharmacology and therapeutics, 2019-07, Vol.106 (1), p.164-173

2019

Link zum Volltext

Verfügbarkeit prüfen

Physiologically based pharmacokinetic modeling and simulation to predict drug–drug interactions of ivosidenib with CYP3A perpetrators in patients with acute myeloid leukemia

Cancer chemotherapy and pharmacology, 2020-11, Vol.86 (5), p.619-632

2020

Link zum Volltext

Verfügbarkeit prüfen

Quantitative Prediction of the Role of Placental Efflux to Optimize Dosing Regimens of Dexamethasone and Betamethasone to Prevent Respiratory Distress Syndrome

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

Link zum Volltext

Verfügbarkeit prüfen

Managing Drug-Drug Interactions in Older Adults

Journal of clinical pharmacology, 2023-10, Vol.63 (10), p.1083-1090

2023

Link zum Volltext

Verfügbarkeit prüfen

A physiologically based pharmacokinetic - pharmacodynamic modelling approach to predict incidence of neutropenia as a result of drug-drug interactions of paclitaxel in cancer patients

European journal of pharmaceutical sciences, 2020-07, Vol.150, p.105355, Article 105355

2020

Link zum Volltext

Verfügbarkeit prüfen

A physiologically based pharmacokinetic model to predict disposition of CYP2D6 and CYP1A2 metabolized drugs in pregnant women

Drug metabolism and disposition, 2013-04, Vol.41 (4), p.801

2013

Link zum Volltext

Verfügbarkeit prüfen

Physiologically Based Pharmacokinetic (PBPK) Modeling for Betrixaban and the Impact of P-Glycoprotein Inhibition on Betrixaban Pharmacokinetics

Blood, 2017-12, Vol.130, p.3663-3663

2017

Link zum Volltext

Verfügbarkeit prüfen

Effects of Strong CYP3A Inhibition and Induction on the Pharmacokinetics of Ixazomib, an Oral Proteasome Inhibitor: Results of Drug‐Drug Interaction Studies in Patients With Advanced Solid Tumors or Lymphoma and a Physiologically Based Pharmacokinetic Analysis

Journal of clinical pharmacology, 2018-02, Vol.58 (2), p.180-192

2018

Link zum Volltext

Verfügbarkeit prüfen

1 – 25 von 238

Suche als RSS-Feed

Suchergebnisse filtern

Filter anzeigen

Nur zeigen

Geprüft (Peer-Review)
(220)
Mit Volltextzugriff
(213)

Publikationsform

Sprache

Erscheinungsjahr

n.n

Thema

Science & Technology
(172)
Life Sciences & Biomedicine
(129)
Humans
(88)
Female
(52)
Animals
(48)
Male
(46)
Pharmacology & Pharmacy
(29)
Physical Sciences
(29)
Aged
(27)
Middle Aged
(27)
Biological And Medical Sciences
(26)
Protoplanetary Disks
(21)
Sciences Of The Universe
(21)
Planet Formation
(20)
Astronomy & Astrophysics
(19)
Medical Sciences
(19)
Mice
(19)
Science & Technology - Other Topics
(18)
Planets
(17)
Astrochemistry
(16)

15 weitere anzeigen...

Weniger anzeigen...

Neu hinzugefügt

... seit 30 Tagen
(3)
... seit 90 Tagen
(5)

Menü

Weitere Dienste

Einstellungen

Physiologically Based Pharmacokinetic Modeling and Allometric Scaling in Pediatric Drug Development: Where Do We Draw the Line?

Impact of Disease on Plasma and Lung Exposure of Chloroquine, Hydroxychloroquine and Azithromycin: Application of PBPK Modeling

In vitro to in vivo extrapolation for high throughput prioritization and decision making

PBPK modeling to predict drug‐drug interactions of ivosidenib as a perpetrator in cancer patients and qualification of the Simcyp platform for CYP3A4 induction

Drug Dosing in Pregnant Women: Challenges and Opportunities in Using Physiologically Based Pharmacokinetic Modeling and Simulations

Utility of Oatp1a/1b-knockout and OATP1B1/3-humanized mice in the study of OATP-mediated pharmacokinetics and tissue distribution: case studies with pravastatin, atorvastatin, simvastatin, and carboxydichlorofluorescein

Physiologically‐based pharmacokinetic modeling of the drug–drug interaction between ivacaftor and lefamulin in cystic fibrosis patients

Estimation of an Appropriate Dose of Trazodone for Pediatric Insomnia and the Potential for a Trazodone–Atomoxetine Interaction

Metformin's Intrinsic Blood-to-Plasma Partition Ratio (B/P): Reconciling the Perceived High In Vivo B/P > 10 with the In Vitro Equilibrium Value of Unity

Pharmacometrics in pregnancy: An unmet need

Clinical pharmacokinetics of leriglitazone and a translational approach using PBPK modeling to guide the selection of the starting dose in children

Clinical CYP3A inhibitor alternatives to ketoconazole, clarithromycin and itraconazole, are not transported into the liver by hepatic organic anion transporting polypeptides and organic cation transporter 1

Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19

Investigational small-molecule drug selectively suppresses constitutive CYP2B6 activity at the gene transcription level: physiologically based pharmacokinetic model assessment of clinical drug interaction risk

Prediction of CYP‐mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator

Physiologically based pharmacokinetic model predictions of ivosidenib (AG-120) as a victim and perpetrator of drug–drug interactions

Estimation of brain receptor occupancy for trazodone immediate release and once a day formulations

Evaluation of Maternal Drug Exposure Following the Administration of Antenatal Corticosteroids During Late Pregnancy Using Physiologically‐Based Pharmacokinetic Modeling

Physiologically based pharmacokinetic modeling and simulation to predict drug–drug interactions of ivosidenib with CYP3A perpetrators in patients with acute myeloid leukemia

Quantitative Prediction of the Role of Placental Efflux to Optimize Dosing Regimens of Dexamethasone and Betamethasone to Prevent Respiratory Distress Syndrome

Managing Drug-Drug Interactions in Older Adults

A physiologically based pharmacokinetic - pharmacodynamic modelling approach to predict incidence of neutropenia as a result of drug-drug interactions of paclitaxel in cancer patients

A physiologically based pharmacokinetic model to predict disposition of CYP2D6 and CYP1A2 metabolized drugs in pregnant women

Physiologically Based Pharmacokinetic (PBPK) Modeling for Betrixaban and the Impact of P-Glycoprotein Inhibition on Betrixaban Pharmacokinetics

Effects of Strong CYP3A Inhibition and Induction on the Pharmacokinetics of Ixazomib, an Oral Proteasome Inhibitor: Results of Drug‐Drug Interaction Studies in Patients With Advanced Solid Tumors or Lymphoma and a Physiologically Based Pharmacokinetic Analysis

Suchergebnisse filtern