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Modeling fragile X syndrome in the Fmr1 knockout mouse

Intractable & Rare Diseases Research, 2014/11/30, Vol.3(4), pp.118-133

2014

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Evaluation of the neuroactive steroid ganaxolone on social and repetitive behaviors in the BTBR mouse model of autism

Psychopharmacology, 2016-01, Vol.233 (2), p.309-323

2016

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Dab1 is required for synaptic plasticity and associative learning

The Journal of neuroscience, 2013-09, Vol.33 (39), p.15652-15668

2013

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Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics

Current topics in behavioral neurosciences, 2016, Vol.28, p.1-52

2016

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R-Baclofen Reverses Cognitive Deficits and Improves Social Interactions in Two Lines of 16p11.2 Deletion Mice

Neuropsychopharmacology (New York, N.Y.), 2018-02, Vol.43 (3), p.513-524

2018

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Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator

Neuropharmacology, 2020-12, Vol.181, p.108333-108333, Article 108333

2020

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Differential roles for Akt and mTORC1 in the hypertrophy of Pten mutant neurons, a cellular model of brain overgrowth disorders

Neuroscience, 2017-06, Vol.354, p.196-207

2017

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Development and Characterization of NEX-Pten, a Novel Forebrain Excitatory Neuron-Specific Knockout Mouse

Developmental neuroscience, 2012-01, Vol.34 (2-3), p.198-209

2012

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SAGE-718: A First-in-Class N‑Methyl‑d‑Aspartate Receptor Positive Allosteric Modulator for the Potential Treatment of Cognitive Impairment

Journal of medicinal chemistry, 2022-07, Vol.65 (13), p.9063-9075

2022

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Pharmacological characterization of SAGE‐718, a novel positive allosteric modulator of N‐methyl‐d‐aspartate receptors

British journal of pharmacology, 2024-04, Vol.181 (7), p.1028-1050

2024

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Hypothesis‐driven investigations of diverse pharmacological targets in two mouse models of autism

Autism research, 2019-03, Vol.12 (3), p.401-421

2019

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Neuroactive Steroid N‑Methyl‑d‑aspartate Receptor Positive Allosteric Modulators: Synthesis, SAR, and Pharmacological Activity

Journal of medicinal chemistry, 2019-08, Vol.62 (16), p.7526-7542

2019

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Targeting mTOR as a novel therapeutic strategy for traumatic CNS injuries

Drug discovery today, 2012-08, Vol.17 (15-16), p.861-868

2012

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Preladenant, a selective A2A receptor antagonist, is active in primate models of movement disorders

Experimental neurology, 2010-10, Vol.225 (2), p.384-390

2010

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Preladenant, a selective A(2A) receptor antagonist, is active in primate models of movement disorders

Experimental neurology, 2010-10, Vol.225 (2), p.384

2010

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Antagonism of the adenosine A2A receptor attenuates akathisia-like behavior induced with MP-10 or aripiprazole in a novel non-human primate model

Pharmacology, biochemistry and behavior, 2014-03, Vol.118, p.36-45

2014

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Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice

Behavioural brain research, 2005-05, Vol.160 (2), p.344-355

2005

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Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination

Pharmacology, biochemistry and behavior, 2011-04, Vol.98 (2), p.181-187

2011

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Automated evaluation of sensitivity to foot shock in mice: inbred strain differences and pharmacological validation

Behavioural pharmacology, 2007-03, Vol.18 (2), p.89-102

2007

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Increased auditory startle response and reduced prepulse inhibition of startle in transgenic mice expressing a double mutant form of amyloid precursor protein

Brain research, 2003-12, Vol.994 (1), p.99-106

2003

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Chronic administration of a novel BACE inhibitor reduced brain Aβ levels and mature plaques and modestly improved cognition in transgenic CRND8-APPswe/ind mice

Alzheimer's & dementia, 2010-07, Vol.6 (4), p.S539-S539

2010

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Targeting m TOR as a novel therapeutic strategy for traumatic CNS injuries

Drug discovery today, 2012, Vol.17 (15-16), p.861-868

2012

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Preladenant, a selective A sub(2A) receptor antagonist, is active in primate models of movement disorders

Experimental neurology, 2010-10, Vol.225 (2), p.384-390

2010

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Preladenant, a selective A 2A receptor antagonist, is active in primate models of movement disorders

Experimental neurology, 2010, Vol.225 (2), p.384-390

2010

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P3‐299: Chronic administration of a novel BACE inhibitor reduced brain Aβ levels and mature plaques and modestly improved cognition in transgenic CRND8‐APP swe/ind mice

Alzheimer's & dementia, 2010-07, Vol.6 (4S_Part_17)

2010

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Modeling fragile X syndrome in the Fmr1 knockout mouse

Evaluation of the neuroactive steroid ganaxolone on social and repetitive behaviors in the BTBR mouse model of autism

Dab1 is required for synaptic plasticity and associative learning

Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics

R-Baclofen Reverses Cognitive Deficits and Improves Social Interactions in Two Lines of 16p11.2 Deletion Mice

Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator

Differential roles for Akt and mTORC1 in the hypertrophy of Pten mutant neurons, a cellular model of brain overgrowth disorders

Development and Characterization of NEX-Pten, a Novel Forebrain Excitatory Neuron-Specific Knockout Mouse

SAGE-718: A First-in-Class N‑Methyl‑d‑Aspartate Receptor Positive Allosteric Modulator for the Potential Treatment of Cognitive Impairment

Pharmacological characterization of SAGE‐718, a novel positive allosteric modulator of N‐methyl‐d‐aspartate receptors

Hypothesis‐driven investigations of diverse pharmacological targets in two mouse models of autism

Neuroactive Steroid N‑Methyl‑d‑aspartate Receptor Positive Allosteric Modulators: Synthesis, SAR, and Pharmacological Activity

Targeting mTOR as a novel therapeutic strategy for traumatic CNS injuries

Preladenant, a selective A2A receptor antagonist, is active in primate models of movement disorders

Preladenant, a selective A(2A) receptor antagonist, is active in primate models of movement disorders

Antagonism of the adenosine A2A receptor attenuates akathisia-like behavior induced with MP-10 or aripiprazole in a novel non-human primate model

Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice

Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination

Automated evaluation of sensitivity to foot shock in mice: inbred strain differences and pharmacological validation

Increased auditory startle response and reduced prepulse inhibition of startle in transgenic mice expressing a double mutant form of amyloid precursor protein

Chronic administration of a novel BACE inhibitor reduced brain Aβ levels and mature plaques and modestly improved cognition in transgenic CRND8-APPswe/ind mice

Targeting m TOR as a novel therapeutic strategy for traumatic CNS injuries

Preladenant, a selective A sub(2A) receptor antagonist, is active in primate models of movement disorders

Preladenant, a selective A 2A receptor antagonist, is active in primate models of movement disorders

P3‐299: Chronic administration of a novel BACE inhibitor reduced brain Aβ levels and mature plaques and modestly improved cognition in transgenic CRND8‐APP swe/ind mice

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