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Synthetic Nanoparticles for Vaccines and Immunotherapy

Chemical reviews, 2015-10, Vol.115 (19), p.11109-11146

2015

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High-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry

Nature communications, 2017-01, Vol.8 (1), p.14069-14069, Article 14069

2017

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Supramolecular Stacking of Doxorubicin on Carbon Nanotubes for In Vivo Cancer Therapy

Angewandte Chemie (International ed.), 2009-01, Vol.48 (41), p.7668-7672

2009

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Engaging natural killer cells for cancer therapy via NKG2D, CD16A and other receptors

mAbs, 2023-12, Vol.15 (1), p.2208697

2023

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Intratumoral injection and retention hold promise to improve cytokine therapies for cancer

Frontiers in oncology, 2024-08, Vol.14, p.1456658

2024

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Pharmacokinetic tuning of protein-antigen fusions enhances the immunogenicity of T-cell vaccines

Nature biomedical engineering, 2020-06, Vol.4 (6), p.636-648

2020

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1093 CLN-617 combines IL-2 and IL-12 in a single molecule to optimally balance safety and efficacy upon intratumoral injection

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A1202-A1202

2023

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Erratum: High-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry

Nature communications, 2017-08, Vol.8 (1), p.15343-15343, Article 15343

2017

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Lymphomas that recur after MYC suppression continue to exhibit oncogene addiction

Proceedings of the National Academy of Sciences - PNAS, 2011-10, Vol.108 (42), p.17432-17437

2011

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Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

Nature medicine, 2016-12, Vol.22 (12), p.1402-1410

2016

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CD4 + T Cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene Inactivation

Cancer cell, 2010-11, Vol.18 (5), p.485-498

2010

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Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells

Science immunology, 2021-03, Vol.6 (57)

2021

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Abstract 5297: CLN-619, a clinical stage MICA/B-specific hIgG1 monoclonal antibody, engages multiple immune effector cells to promote anti-tumor activity

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.5297-5297

2024

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Abstract 1839: CLN-617 is a first-in-class fusion protein that retains IL-2 and IL-12 in the injected tumor and potently triggers systemic anti-tumor immunity

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.1839-1839

2023

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Abstract 3505: CLN-617 is an IL-2/IL-12 fusion protein with a collagen-anchoring domain that induces potent systemic anti-tumor immunity upon intra-tumoral administration

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.3505-3505

2022

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CLN-617 Retains IL2 and IL12 in Injected Tumors to Drive Robust and Systemic Immune-Mediated Antitumor Activity

Cancer immunology research, 2024-08, Vol.12 (8), p.1022-1038

2024

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CD4+ T Cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene Inactivation

Cancer cell, 2010-12, Vol.18 (6), p.696-696

2010

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Abstract A42: Combination immunotherapy of an autochthonous murine lung cancer model expressing human CEA as a tumor-associated self-antigen

Cancer immunology research, 2017-03, Vol.5 (3_Supplement), p.A42-A42

2017

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Abstract B120: Characterization and combination immunotherapy treatment of an inducible autochthonous murine lung cancer model expressing human carcinoembryonic antigen (CEA) as a tumor-associated self-antigen

Cancer immunology research, 2016-01, Vol.4 (1_Supplement), p.B120-B120

2016

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In Vivo Imaging-Based Mathematical Modeling Techniques That Enhance the Understanding of Oncogene Addiction in relation to Tumor Growth

Computational and mathematical methods in medicine, 2013-01, Vol.2013 (2013), p.1-8

2013

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Abstract A52: Eradication of large established tumors with combination immunotherapy engaging innate and adaptive immunity

Cancer immunology research, 2017-03, Vol.5 (3_Supplement), p.A52-A52

2017

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An Essential Role of the Immune System in Remodeling the Tumor Microenvironment upon Oncogene Inactivation

Rakhra, Kavya

2011

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Supramolecular Stacking of Doxorubicin on Carbon Nanotubes for In Vivo Cancer Therapy

Angewandte Chemie, 2009-09, Vol.121 (41), p.7804-7808

2009

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Generation of a tetracycline regulated mouse model of MYC-induced T-cell acute lymphoblastic leukemia

Methods in molecular biology (Clifton, N.J.), 2013, Vol.1012, p.221

2013

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Synthesis of N4-(2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors

Acta pharmaceutica (Zagreb, Croatia), 2006-09, Vol.56 (3), p.259

2006

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Synthetic Nanoparticles for Vaccines and Immunotherapy

High-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry

Supramolecular Stacking of Doxorubicin on Carbon Nanotubes for In Vivo Cancer Therapy

Engaging natural killer cells for cancer therapy via NKG2D, CD16A and other receptors

Intratumoral injection and retention hold promise to improve cytokine therapies for cancer

Pharmacokinetic tuning of protein-antigen fusions enhances the immunogenicity of T-cell vaccines

1093 CLN-617 combines IL-2 and IL-12 in a single molecule to optimally balance safety and efficacy upon intratumoral injection

Erratum: High-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry

Lymphomas that recur after MYC suppression continue to exhibit oncogene addiction

Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

CD4 + T Cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene Inactivation

Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells

Abstract 5297: CLN-619, a clinical stage MICA/B-specific hIgG1 monoclonal antibody, engages multiple immune effector cells to promote anti-tumor activity

Abstract 1839: CLN-617 is a first-in-class fusion protein that retains IL-2 and IL-12 in the injected tumor and potently triggers systemic anti-tumor immunity

Abstract 3505: CLN-617 is an IL-2/IL-12 fusion protein with a collagen-anchoring domain that induces potent systemic anti-tumor immunity upon intra-tumoral administration

CLN-617 Retains IL2 and IL12 in Injected Tumors to Drive Robust and Systemic Immune-Mediated Antitumor Activity

CD4+ T Cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene Inactivation

Abstract A42: Combination immunotherapy of an autochthonous murine lung cancer model expressing human CEA as a tumor-associated self-antigen

Abstract B120: Characterization and combination immunotherapy treatment of an inducible autochthonous murine lung cancer model expressing human carcinoembryonic antigen (CEA) as a tumor-associated self-antigen

In Vivo Imaging-Based Mathematical Modeling Techniques That Enhance the Understanding of Oncogene Addiction in relation to Tumor Growth

Abstract A52: Eradication of large established tumors with combination immunotherapy engaging innate and adaptive immunity

An Essential Role of the Immune System in Remodeling the Tumor Microenvironment upon Oncogene Inactivation

Supramolecular Stacking of Doxorubicin on Carbon Nanotubes for In Vivo Cancer Therapy

Generation of a tetracycline regulated mouse model of MYC-induced T-cell acute lymphoblastic leukemia

Synthesis of N4-(2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors

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