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Spectroscopic and Electronic Structure Studies of Aromatic Electrophilic Attack and Hydrogen-Atom Abstraction by Non-Heme Iron Enzymes

Proceedings of the National Academy of Sciences - PNAS, 2006-08, Vol.103 (35), p.12966-12973

2006

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PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain

Journal of lipid research, 2010-09, Vol.51 (9), p.2611-2618

2010

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Bridging Model-Dependent Receptor Agonism and Allosterism Parameterization

Trends in pharmacological sciences (Regular ed.), 2016-05, Vol.37 (5), p.329-331

2016

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A Panoramic Measure of Agonist, Modulator, Receptor and Signaling Pathway Selectivity

The FASEB journal, 2016-04, Vol.30 (S1)

2016

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Quantitative Measure of Receptor Agonist and Modulator Equi-Response and Equi-Occupancy Selectivity

Scientific reports, 2016-04, Vol.6 (1), p.25158-25158, Article 25158

2016

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Global Curve Fitting Approach to Receptor Allosterism

The FASEB journal, 2015-04, Vol.29 (S1)

2015

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Quantitative analysis of receptor allosterism and its implication for drug discovery

Expert opinion on drug discovery, 2015-07, Vol.10 (7), p.763-780

2015

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From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9

Cell chemical biology, 2020-01, Vol.27 (1), p.32-40.e3

2020

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Hydrogen Transfer to Carbonyls and Imines from a Hydroxycyclopentadienyl Ruthenium Hydride: Evidence for Concerted Hydride and Proton Transfer

Journal of the American Chemical Society, 2001-02, Vol.123 (6), p.1090-1100

2001

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From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9

Cell chemical biology, 2021-02, Vol.28 (2), p.243

2021

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Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus

Bioorganic & medicinal chemistry letters, 2017-05, Vol.27 (9), p.2069-2073

2017

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Quantitation of wall teichoic acid in Staphylococcus aureus by direct measurement of monomeric units using LC-MS/MS

Analytical biochemistry, 2017-02, Vol.518, p.9-15

2017

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Interaction of (4-Hydroxyphenyl)pyruvate Dioxygenase with the Specific Inhibitor 2-[2-Nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione

Biochemistry (Easton), 2003-09, Vol.42 (34), p.10238-10245

2003

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Abstract 15853: Identification of Novel Sites Required for PCSK9 Autocatalytic Cleavage

Circulation (New York, N.Y.), 2015-11, Vol.132 (Suppl_3 Suppl 3), p.A15853-A15853

2015

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Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus

Bioorganic & medicinal chemistry letters, 2017-05, Vol.27 (9), p.2063-2068

2017

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Investigation of Functionally Liver Selective Glucokinase Activators for the Treatment of Type 2 Diabetes

Journal of medicinal chemistry, 2009-10, Vol.52 (19), p.6142-6152

2009

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Resveratrol inhibits firefly luciferase

Biochemical and biophysical research communications, 2006-12, Vol.351 (2), p.481-484

2006

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In Vitro Assays for the Discovery of PCSK9 Autoprocessing Inhibitors

Journal of biomolecular screening, 2016-12, Vol.21 (10), p.1034-1041

2016

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Moderate to high throughput in vitro binding kinetics for drug discovery

Frontiers in bioscience (Scholar edition), 2016-06, Vol.8 (2), p.278

2016

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(4-Hydroxyphenyl)pyruvate Dioxygenase from Streptomyces avermitilis: The Basis for Ordered Substrate Addition

Biochemistry (Easton), 2003-02, Vol.42 (7), p.2072-2080

2003

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CD and MCD Studies of the Non-Heme Ferrous Active Site in (4-Hydroxyphenyl)pyruvate Dioxygenase: Correlation between Oxygen Activation in the Extradiol and α-KG-Dependent Dioxygenases

Journal of the American Chemical Society, 2004-04, Vol.126 (14), p.4486-4487

2004

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Spectroscopic and computational studies of NTBC bound to the non-heme iron enzyme (4-hydroxyphenyl)pyruvate dioxygenase: Active site contributions to drug inhibition

Biochemical and biophysical research communications, 2005-12, Vol.338 (1), p.206-214

2005

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Label-Free, LC-MS-Based Assays to Quantitate Small-Molecule Antagonist Binding to the Mammalian BLT1 Receptor

SLAS discovery, 2017-10, Vol.22 (9), p.1131-1141

2017

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Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (10), p.2804-2807

2009

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Accumulation of Multiple Intermediates in the Catalytic Cycle of (4-Hydroxyphenyl)pyruvate Dioxygenase from Streptomyces avermitilis

Biochemistry (Easton), 2005-05, Vol.44 (19), p.7189-7199

2005

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Spectroscopic and Electronic Structure Studies of Aromatic Electrophilic Attack and Hydrogen-Atom Abstraction by Non-Heme Iron Enzymes

PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain

Bridging Model-Dependent Receptor Agonism and Allosterism Parameterization

A Panoramic Measure of Agonist, Modulator, Receptor and Signaling Pathway Selectivity

Quantitative Measure of Receptor Agonist and Modulator Equi-Response and Equi-Occupancy Selectivity

Global Curve Fitting Approach to Receptor Allosterism

Quantitative analysis of receptor allosterism and its implication for drug discovery

From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9

Hydrogen Transfer to Carbonyls and Imines from a Hydroxycyclopentadienyl Ruthenium Hydride: Evidence for Concerted Hydride and Proton Transfer

From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9

Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus

Quantitation of wall teichoic acid in Staphylococcus aureus by direct measurement of monomeric units using LC-MS/MS

Interaction of (4-Hydroxyphenyl)pyruvate Dioxygenase with the Specific Inhibitor 2-[2-Nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione

Abstract 15853: Identification of Novel Sites Required for PCSK9 Autocatalytic Cleavage

Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus

Investigation of Functionally Liver Selective Glucokinase Activators for the Treatment of Type 2 Diabetes

Resveratrol inhibits firefly luciferase

In Vitro Assays for the Discovery of PCSK9 Autoprocessing Inhibitors

Moderate to high throughput in vitro binding kinetics for drug discovery

(4-Hydroxyphenyl)pyruvate Dioxygenase from Streptomyces avermitilis: The Basis for Ordered Substrate Addition

CD and MCD Studies of the Non-Heme Ferrous Active Site in (4-Hydroxyphenyl)pyruvate Dioxygenase: Correlation between Oxygen Activation in the Extradiol and α-KG-Dependent Dioxygenases

Spectroscopic and computational studies of NTBC bound to the non-heme iron enzyme (4-hydroxyphenyl)pyruvate dioxygenase: Active site contributions to drug inhibition

Label-Free, LC-MS-Based Assays to Quantitate Small-Molecule Antagonist Binding to the Mammalian BLT1 Receptor

Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase

Accumulation of Multiple Intermediates in the Catalytic Cycle of (4-Hydroxyphenyl)pyruvate Dioxygenase from Streptomyces avermitilis

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