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Poly (ADP-ribose) polymerase inhibitors: recent advances and future development

Journal of clinical oncology, 2015-04, Vol.33 (12), p.1397-1406

2015

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Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells

Proceedings of the National Academy of Sciences - PNAS, 2011-02, Vol.108 (8), p.3406-3411

2011

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FAM111A protects replication forks from protein obstacles via its trypsin-like domain

Nature communications, 2020-03, Vol.11 (1), p.1318-1318, Article 1318

2020

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Failure of Iniparib to Inhibit Poly(ADP-Ribose) Polymerase In Vitro

Clinical cancer research, 2012-03, Vol.18 (6), p.1655-1662

2012

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Characterization of an alternative BAK-binding site for BH3 peptides

Nature communications, 2020-07, Vol.11 (1), p.1-14, Article 3301

2020

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ATR Inhibition Broadly Sensitizes Ovarian Cancer Cells to Chemotherapy Independent of BRCA Status

Cancer research (Chicago, Ill.), 2013-06, Vol.73 (12), p.3683-3691

2013

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Evaluation of the BH3-only Protein Puma as a Direct Bak Activator

The Journal of biological chemistry, 2014-01, Vol.289 (1), p.89-99

2014

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COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A

Molecular biology of the cell, 2015-01, Vol.26 (1), p.91-103

2015

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A cell cycle-dependent BRCA1–UHRF1 cascade regulates DNA double-strand break repair pathway choice

Nature communications, 2016-01, Vol.7 (1), p.10201-10201, Article 10201

2016

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Reactivating latent HIV with PKC agonists induces resistance to apoptosis and is associated with phosphorylation and activation of BCL2

PLoS pathogens, 2020-10, Vol.16 (10), p.e1008906-e1008906

2020

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The DNA Cytosine Deaminase APOBEC3B is a Molecular Determinant of Platinum Responsiveness in Clear Cell Ovarian Cancer

Clinical cancer research, 2020-07, Vol.26 (13), p.3397-3407

2020

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Diagnostic and prognostic potential of the microbiome in ovarian cancer treatment response

Scientific reports, 2023-01, Vol.13 (1), p.730-18, Article 730

2023

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Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

The Journal of cell biology, 2011-07, Vol.194 (1), p.39-48

2011

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How does doxorubicin work?

eLife, 2012-12, Vol.1, p.e00387-e00387

2012

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Topoisomerases and cancer chemotherapy: recent advances and unanswered questions [version 1; peer review: 3 approved]

F1000 research, 2019, Vol.8, p.1704

2019

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ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance

Nucleic acids research, 2023-11, Vol.51 (20), p.11056-11079

2023

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Eltrombopag directly activates BAK and induces apoptosis

Cell death & disease, 2023-07, Vol.14 (7), p.394-394, Article 394

2023

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A phase I study of pevonedistat, azacitidine, and venetoclax in patients with relapsed/refractory acute myeloid leukemia

Haematologica (Roma), 2024-09, Vol.109 (9), p.2864

2024

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Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells

Cell death & disease, 2021-10, Vol.12 (11), p.977-977, Article 977

2021

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DAGBagM: learning directed acyclic graphs of mixed variables with an application to identify protein biomarkers for treatment response in ovarian cancer

BMC bioinformatics, 2022-08, Vol.23 (1), p.321-19, Article 321

2022

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Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2

Blood, 2009-10, Vol.114 (14), p.2926-2935

2009

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Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells

Genes & development, 2015-10, Vol.29 (20), p.2140-2152

2015

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Enhanced Killing of Cancer Cells by Poly(ADP-ribose) Polymerase Inhibitors and Topoisomerase I Inhibitors Reflects Poisoning of Both Enzymes

The Journal of biological chemistry, 2012-02, Vol.287 (6), p.4198-4210

2012

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Fibroblast growth factor receptor inhibition induces loss of matrix MCL1 and necrosis in cholangiocarcinoma

Journal of hepatology, 2018-06, Vol.68 (6), p.1228-1238

2018

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Poly (ADP-ribose) polymerase inhibitors: recent advances and future development

Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells

BRCA Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma

FAM111A protects replication forks from protein obstacles via its trypsin-like domain

Failure of Iniparib to Inhibit Poly(ADP-Ribose) Polymerase In Vitro

Characterization of an alternative BAK-binding site for BH3 peptides

ATR Inhibition Broadly Sensitizes Ovarian Cancer Cells to Chemotherapy Independent of BRCA Status

Evaluation of the BH3-only Protein Puma as a Direct Bak Activator

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A

A cell cycle-dependent BRCA1–UHRF1 cascade regulates DNA double-strand break repair pathway choice

Reactivating latent HIV with PKC agonists induces resistance to apoptosis and is associated with phosphorylation and activation of BCL2

The DNA Cytosine Deaminase APOBEC3B is a Molecular Determinant of Platinum Responsiveness in Clear Cell Ovarian Cancer

Diagnostic and prognostic potential of the microbiome in ovarian cancer treatment response

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

How does doxorubicin work?

Topoisomerases and cancer chemotherapy: recent advances and unanswered questions [version 1; peer review: 3 approved]

ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance

Eltrombopag directly activates BAK and induces apoptosis

A phase I study of pevonedistat, azacitidine, and venetoclax in patients with relapsed/refractory acute myeloid leukemia

Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells

DAGBagM: learning directed acyclic graphs of mixed variables with an application to identify protein biomarkers for treatment response in ovarian cancer

Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2

Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells

Enhanced Killing of Cancer Cells by Poly(ADP-ribose) Polymerase Inhibitors and Topoisomerase I Inhibitors Reflects Poisoning of Both Enzymes

Fibroblast growth factor receptor inhibition induces loss of matrix MCL1 and necrosis in cholangiocarcinoma

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