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Evaluating the Differences in Cycloalkyl Ether Metabolism Using the Design Parameter “Lipophilic Metabolism Efficiency” (LipMetE) and a Matched Molecular Pairs Analysis

Journal of medicinal chemistry, 2013-09, Vol.56 (17), p.6985-6990

2013

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Physicochemical Features of the hERG Channel Drug Binding Site

The Journal of biological chemistry, 2004-03, Vol.279 (11), p.10120-10127

2004

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Extraction of tacit knowledge from large ADME data sets via pairwise analysis

Bioorganic & medicinal chemistry, 2011-06, Vol.19 (12), p.3739-3749

2011

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Quantitative Assessment of the Impact of Fluorine Substitution on P‑Glycoprotein (P-gp) Mediated Efflux, Permeability, Lipophilicity, and Metabolic Stability

Journal of medicinal chemistry, 2016-06, Vol.59 (11), p.5284-5296

2016

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Assessing Physicochemical Properties of Drug Molecules via Microsolvation Measurements with Differential Mobility Spectrometry

ACS central science, 2017-02, Vol.3 (2), p.101-109

2017

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Interpretable, Probability-Based Confidence Metric for Continuous Quantitative Structure–Activity Relationship Models

Journal of chemical information and modeling, 2013-02, Vol.53 (2), p.368-383

2013

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Structure-Based Optimization of a Series of Covalent, Cell Active Bfl‑1 Inhibitors

Journal of medicinal chemistry, 2024-09, Vol.67 (18), p.16455-16479

2024

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Novel γ-secretase modulators for the treatment of Alzheimer's disease: a review focusing on patents from 2010 to 2012

Expert opinion on therapeutic patents, 2013-10, Vol.23 (10), p.1349-1366

2013

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A multi-endpoint matched molecular pair (MMP) analysis of 6-membered heterocycles

Bioorganic & medicinal chemistry, 2017-01, Vol.25 (1), p.381-388

2017

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Correction to “Assessing Physicochemical Properties of Drug Molecules via Microsolvation Measurements with Differential Mobility Spectrometry”

ACS central science, 2017-04, Vol.3 (4), p.359-359

2017

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Strategies toward optimization of the metabolism of a series of serotonin-4 partial agonists: investigation of azetidines as piperidine isosteres

Xenobiotica, 2016-12, Vol.46 (12), p.1112-1121

2016

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Design and Discovery of a Selective Small Molecule κ Opioid Antagonist (2-Methyl-N-((2′-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine, PF-4455242)

Journal of medicinal chemistry, 2011-08, Vol.54 (16), p.5868-5877

2011

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Design and optimization of selective azaindole amide M1 positive allosteric modulators

Bioorganic & medicinal chemistry letters, 2016-01, Vol.26 (2), p.650-655

2016

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Design, Synthesis, and Pharmacological Evaluation of a Novel Series of Pyridopyrazine-1,6-dione γ‑Secretase Modulators

Journal of medicinal chemistry, 2014-02, Vol.57 (3), p.1046-1062

2014

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Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin

Bioorganic & medicinal chemistry letters, 2015-02, Vol.25 (4), p.908-913

2015

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Novel γ-secretase modulators: a review of patents from 2008 to 2010

Expert opinion on therapeutic patents, 2011-02, Vol.21 (2), p.205-226

2011

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Design of Pyridopyrazine-1,6-dione γ‑Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability

ACS medicinal chemistry letters, 2015-05, Vol.6 (5), p.596-601

2015

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Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators

Bioorganic & medicinal chemistry letters, 2012-04, Vol.22 (8), p.2906-2911

2012

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QSAR and k-Nearest Neighbor Classification Analysis of Selective Cyclooxygenase-2 Inhibitors Using Topologically-Based Numerical Descriptors

Journal of Chemical Information and Computer Sciences, 2001-11, Vol.41 (6), p.1553-1560

2001

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Prediction of Surface Tension, Viscosity, and Thermal Conductivity for Common Organic Solvents Using Quantitative Structure−Property Relationships

Journal of Chemical Information and Computer Sciences, 2001-03, Vol.41 (2), p.408-418

2001

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Design and optimization of selective azaindole amide M 1 positive allosteric modulators

Bioorganic & medicinal chemistry letters, 2016-01, Vol.26 (2), p.650-655

2016

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Evaluating the Differences in Cycloalkyl Ether Metabolism Using the Design Parameter “Lipophilic Metabolism Efficiency” (LipMetE) and a Matched Molecular Pairs Analysis

Physicochemical Features of the hERG Channel Drug Binding Site

Extraction of tacit knowledge from large ADME data sets via pairwise analysis

Quantitative Assessment of the Impact of Fluorine Substitution on P‑Glycoprotein (P-gp) Mediated Efflux, Permeability, Lipophilicity, and Metabolic Stability

Assessing Physicochemical Properties of Drug Molecules via Microsolvation Measurements with Differential Mobility Spectrometry

Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor

Interpretable, Probability-Based Confidence Metric for Continuous Quantitative Structure–Activity Relationship Models

Discovery of the Potent and Selective M1 PAM-Agonist N‑[(3R,4S)‑3-Hydroxytetrahydro‑2H‑pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects

Structure-Based Optimization of a Series of Covalent, Cell Active Bfl‑1 Inhibitors

Discovery of Clinical Candidate PF-06648671: A Potent γ‑Secretase Modulator for the Treatment of Alzheimer’s Disease

Novel γ-secretase modulators for the treatment of Alzheimer's disease: a review focusing on patents from 2010 to 2012

A multi-endpoint matched molecular pair (MMP) analysis of 6-membered heterocycles

Correction to “Assessing Physicochemical Properties of Drug Molecules via Microsolvation Measurements with Differential Mobility Spectrometry”

Strategies toward optimization of the metabolism of a series of serotonin-4 partial agonists: investigation of azetidines as piperidine isosteres

Design and Discovery of a Selective Small Molecule κ Opioid Antagonist (2-Methyl-N-((2′-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine, PF-4455242)

Design and optimization of selective azaindole amide M1 positive allosteric modulators

Design, Synthesis, and Pharmacological Evaluation of a Novel Series of Pyridopyrazine-1,6-dione γ‑Secretase Modulators

Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin

Novel γ-secretase modulators: a review of patents from 2008 to 2010

Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy

Design of Pyridopyrazine-1,6-dione γ‑Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability

Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators

QSAR and k-Nearest Neighbor Classification Analysis of Selective Cyclooxygenase-2 Inhibitors Using Topologically-Based Numerical Descriptors

Prediction of Surface Tension, Viscosity, and Thermal Conductivity for Common Organic Solvents Using Quantitative Structure−Property Relationships

Design and optimization of selective azaindole amide M 1 positive allosteric modulators

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