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Structure-based development of specific inhibitors for individual cathepsins and their medical applications

Proceedings of the Japan Academy, Series B, 2011/02/10, Vol.87(2), pp.29-39

KATUNUMA, Nobuhiko

2011

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An Active 32-kDa Cathepsin L Is Secreted Directly from HT 1080 Fibrosarcoma Cells and Not via Lysosomal Exocytosis

PloS one, 2015-12, Vol.10 (12), p.e0145067-e0145067

2015

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Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells

The Journal of Medical Investigation, 2005, Vol.52(1,2), pp.1-9

2005

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Structural basis of actin recognition and arginine ADP-ribosylation by Clostridium perfringens ι-toxin

Proceedings of the National Academy of Sciences - PNAS, 2008-05, Vol.105 (21), p.7399-7404

2008

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Processing of Human Cathepsin D Is Independent of Its Catalytic Function and Auto-Activation: Involvement of Cathepsins L and B

Journal of biochemistry (Tokyo), 2006-03, Vol.139 (3), p.363-371

2006

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Cathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8(+) T cell activity

PloS one, 2010-09, Vol.5 (9), p.e12894-e12894

2010

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L-Tryptophan Suppresses Rise in Blood Glucose and Preserves Insulin Secretion in Type-2 Diabetes Mellitus Rats

Journal of Nutritional Science and Vitaminology, 2012, Vol.58(6), pp.415-422

2012

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Cathepsin L activity controls adipogenesis and glucose tolerance

Nature cell biology, 2007-08, Vol.9 (8), p.970-977

2007

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Structural Basis of the Sphingomyelin Phosphodiesterase Activity in Neutral Sphingomyelinase from Bacillus cereus

The Journal of biological chemistry, 2006-06, Vol.281 (23), p.16157-16167

2006

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Processing of human protryptase in mast cells involves cathepsins L, B, and C

The Journal of immunology (1950), 2011-08, Vol.187 (4), p.1912-1918

2011

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Structural Basis for the Kexin-like Serine Protease from Aeromonas sobria as Sepsis-causing Factor

The Journal of biological chemistry, 2009-10, Vol.284 (40), p.27655-27663

2009

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CD4-independent human immunodeficiency virus infection involves participation of endocytosis and cathepsin B

PloS one, 2011-04, Vol.6 (4), p.e19352-e19352

2011

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Structure-based drug development and medical/biological application of cathepsin specific inhibitors

Seikagaku. The Journal of Japanese Biochemical Society, 2009-11, Vol.81 (11), p.952

Katunuma, Nobuhiko

2009

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Posttranslational Processing and Modification of Cathepsins and Cystatins

Journal of Signal Transduction, 2010-01, Vol.2010, p.375345-8

2010

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Genetic and Pharmacologic Alteration of Cathepsin Expression Influences Reovirus Pathogenesis

Journal of Virology, 2009-10, Vol.83 (19), p.9630-9640

2009

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Crystal Structure and Site-directed Mutagenesis of Enzymatic Components from Clostridium perfringens Iota-toxin

Journal of molecular biology, 2003-01, Vol.325 (3), p.471-483

2003

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Structure of l-aspartate oxidase from the hyperthermophilic archaeon Sulfolobus tokodaii

Biochimica et biophysica acta, 2008-03, Vol.1784 (3), p.563-571

2008

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Crystal structure of archaeal highly thermostable L‐aspartate dehydrogenase/NAD/citrate ternary complex

The FEBS journal, 2007-08, Vol.274 (16), p.4315-4325

2007

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Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells

Virology (New York, N.Y.), 2009-11, Vol.394 (2), p.227-234

2009

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Significance of Cathepsin B Accumulation in Synovial Fluid of Rheumatoid Arthritis

Biochemical and biophysical research communications, 2001-05, Vol.283 (2), p.334-339

2001

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Autophagy and cathepsin L are involved in the antinociceptive effect of DMBC in a mouse acetic acid-writhing model

Acta pharmacologica Sinica, 2013-08, Vol.34 (8), p.1007-1012

2013

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Crystal Structure of the NAD Biosynthetic Enzyme Quinolinate Synthase

The Journal of biological chemistry, 2005-07, Vol.280 (29), p.26645-26648

2005

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Crystal Structure of a Novel FAD-, FMN-, and ATP-containing l-Proline Dehydrogenase Complex from Pyrococcus horikoshii

The Journal of biological chemistry, 2005-09, Vol.280 (35), p.31045-31049

2005

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The First Crystal Structure of Hyperthermostable NAD-dependent Glutamate Dehydrogenase from Pyrobaculum islandicum

Journal of molecular biology, 2005-01, Vol.345 (2), p.325-337

2005

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Inhibition of collagenolytic cathepsins by beta-lactoglobulin in milk and its suppressive effect on bone resorption

Journal of Nutritional Science and Vitaminology, 2009, Vol.55(3), pp.264-270

2009

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Structure-based development of specific inhibitors for individual cathepsins and their medical applications

An Active 32-kDa Cathepsin L Is Secreted Directly from HT 1080 Fibrosarcoma Cells and Not via Lysosomal Exocytosis

Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells

Structural basis of actin recognition and arginine ADP-ribosylation by Clostridium perfringens ι-toxin

Processing of Human Cathepsin D Is Independent of Its Catalytic Function and Auto-Activation: Involvement of Cathepsins L and B

Cathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8(+) T cell activity

L-Tryptophan Suppresses Rise in Blood Glucose and Preserves Insulin Secretion in Type-2 Diabetes Mellitus Rats

Cathepsin L activity controls adipogenesis and glucose tolerance

Structural Basis of the Sphingomyelin Phosphodiesterase Activity in Neutral Sphingomyelinase from Bacillus cereus

Processing of human protryptase in mast cells involves cathepsins L, B, and C

Structural Basis for the Kexin-like Serine Protease from Aeromonas sobria as Sepsis-causing Factor

CD4-independent human immunodeficiency virus infection involves participation of endocytosis and cathepsin B

Structure-based drug development and medical/biological application of cathepsin specific inhibitors

Posttranslational Processing and Modification of Cathepsins and Cystatins

Genetic and Pharmacologic Alteration of Cathepsin Expression Influences Reovirus Pathogenesis

Crystal Structure and Site-directed Mutagenesis of Enzymatic Components from Clostridium perfringens Iota-toxin

Structure of l-aspartate oxidase from the hyperthermophilic archaeon Sulfolobus tokodaii

Crystal structure of archaeal highly thermostable L‐aspartate dehydrogenase/NAD/citrate ternary complex

Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells

Significance of Cathepsin B Accumulation in Synovial Fluid of Rheumatoid Arthritis

Autophagy and cathepsin L are involved in the antinociceptive effect of DMBC in a mouse acetic acid-writhing model

Crystal Structure of the NAD Biosynthetic Enzyme Quinolinate Synthase

Crystal Structure of a Novel FAD-, FMN-, and ATP-containing l-Proline Dehydrogenase Complex from Pyrococcus horikoshii

The First Crystal Structure of Hyperthermostable NAD-dependent Glutamate Dehydrogenase from Pyrobaculum islandicum

Inhibition of collagenolytic cathepsins by beta-lactoglobulin in milk and its suppressive effect on bone resorption

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