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Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

Biochemical journal, 2010-10, Vol.431 (2), p.245-255

2010

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Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition

Structure (London), 2013-02, Vol.21 (2), p.209-219

2013

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A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

Nature chemical biology, 2014-09, Vol.10 (9), p.760

2014

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Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance

Proceedings of the National Academy of Sciences - PNAS, 2014-01, Vol.111 (1), p.173-178

2014

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Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors

Cell chemical biology, 2017-11, Vol.24 (11), p.1388-1400.e7

2017

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Cellular Characterization of a Novel Focal Adhesion Kinase Inhibitor

The Journal of biological chemistry, 2007-05, Vol.282 (20), p.14845-14852

2007

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Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes

Journal of the American Chemical Society, 2017-01, Vol.139 (2), p.680-685

2017

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Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis

Proceedings of the National Academy of Sciences - PNAS, 2007-06, Vol.104 (25), p.10619-10624

2007

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Reversible lysine-targeted probes reveal residence time-based kinase selectivity

Nature chemical biology, 2022-09, Vol.18 (9), p.934

2022

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Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations

Journal of medicinal chemistry, 2014-06, Vol.57 (11), p.4720-4744

2014

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Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451

Cancer research (Chicago, Ill.), 2005-02, Vol.65 (3), p.957-966

2005

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Study of the PDK1/AKT signaling pathway using selective PDK1 inhibitors, HCS, and enhanced biochemical assays

Analytical biochemistry, 2011-07, Vol.414 (2), p.179-186

2011

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Discovery of N‑((3R,4R)‑4-Fluoro-1-(6-((3-methoxy-1-methyl‑1H‑pyrazol-4-yl)amino)-9-methyl‑9H‑purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.3002-3019

2017

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Discovery of 1‑{(3R,4R)‑3-[({5-Chloro-2-[(1-methyl‑1H‑pyrazol-4-yl)amino]‑7H‑pyrrolo[2,3‑d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants

Journal of medicinal chemistry, 2016-03, Vol.59 (5), p.2005-2024

2016

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Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

Chembiochem : a European journal of chemical biology, 2016-10, Vol.17 (20), p.1925-1930

2016

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CP-481,715, a Potent and Selective CCR1 Antagonist with Potential Therapeutic Implications for Inflammatory Diseases

The Journal of biological chemistry, 2003-10, Vol.278 (42), p.40473-40480

2003

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Daphniphyllum Alkaloids. 16. Total Synthesis of (+)-Codaphniphylline

Journal of organic chemistry, 1995-03, Vol.60 (5), p.1120-1130

1995

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Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor

Cancer research (Chicago, Ill.), 2007-10, Vol.67 (20), p.9887-9893

2007

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Daphniphyllum alkaloids. 11. Biomimetic total synthesis of methyl homosecodaphniphyllate. Development of the tetracyclization reaction

Journal of organic chemistry, 1992-04, Vol.57 (9), p.2544-2553

1992

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5-Bromo-3-(indan-1-yl-oxy)pyridin-2-amine

Acta crystallographica. Section E, Structure reports online, 2011-02, Vol.67 (Pt 3), p.o650-o650

2011

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The biological and biochemical effects of CP-654577, a selective erbB2 kinase inhibitor, on human breast cancer cells

Cancer research (Chicago, Ill.), 2003-08, Vol.63 (15), p.4450-4459

2003

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UK‐78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage‐gated potassium channel and inhibits human T cell activation

British journal of pharmacology, 1999-04, Vol.126 (8), p.1707-1716

1999

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The discovery of structurally novel CCR1 antagonists derived from a hydroxyethylene peptide isostere template

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (9), p.2163-2167

2004

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Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition

A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance

Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors

Cellular Characterization of a Novel Focal Adhesion Kinase Inhibitor

Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes

Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis

Reversible lysine-targeted probes reveal residence time-based kinase selectivity

Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451

Study of the PDK1/AKT signaling pathway using selective PDK1 inhibitors, HCS, and enhanced biochemical assays

Discovery of 1‑{(3R,4R)‑3-[({5-Chloro-2-[(1-methyl‑1H‑pyrazol-4-yl)amino]‑7H‑pyrrolo[2,3‑d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants

Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195)

Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

CP-481,715, a Potent and Selective CCR1 Antagonist with Potential Therapeutic Implications for Inflammatory Diseases

Daphniphyllum Alkaloids. 16. Total Synthesis of (+)-Codaphniphylline

Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor

Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2) : Structure-activity relationships and strategies for the elimination of reactive metabolite formation

Daphniphyllum alkaloids. 11. Biomimetic total synthesis of methyl homosecodaphniphyllate. Development of the tetracyclization reaction

5-Bromo-3-(indan-1-yl-oxy)pyridin-2-amine

The biological and biochemical effects of CP-654577, a selective erbB2 kinase inhibitor, on human breast cancer cells

UK‐78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage‐gated potassium channel and inhibits human T cell activation

The discovery of structurally novel CCR1 antagonists derived from a hydroxyethylene peptide isostere template

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