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Discovery of Alogliptin: A Potent, Selective, Bioavailable, and Efficacious Inhibitor of Dipeptidyl Peptidase IV

Journal of medicinal chemistry, 2007-05, Vol.50 (10), p.2297-2300

2007

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Applications of high-throughput ADME in drug discovery

Current opinion in chemical biology, 2004-06, Vol.8 (3), p.339-345

Kassel, Daniel B

2004

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Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV

Journal of medicinal chemistry, 2011-01, Vol.54 (2), p.510-524

2011

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Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptidyl peptidase-4, in rats, dogs, and monkeys

European journal of pharmacology, 2008-07, Vol.589 (1-3), p.306-314

2008

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Two-dimensional supercritical fluid chromatography/mass spectrometry for the enantiomeric analysis and purification of pharmaceutical samples

Journal of Chromatography A, 2011-05, Vol.1218 (20), p.3080-3088

2011

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Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation

The Journal of biological chemistry, 2003-08, Vol.278 (34), p.31461-31464

2003

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A high throughput metabolic stability screening workflow with automated assessment of data quality in pharmaceutical industry

Journal of Chromatography A, 2010-03, Vol.1217 (10), p.1616-1625

2010

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Phosphopeptides enrichment using on-line two-dimensional strong cation exchange followed by reversed-phase liquid chromatography/mass spectrometry

Analytical biochemistry, 2006-07, Vol.354 (2), p.213-219

2006

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Developments of a Fully Automated Parallel HPLC/Mass Spectrometry System for the Analytical Characterization and Preparative Purification of Combinatorial Libraries

Analytical chemistry (Washington), 1998-10, Vol.70 (20), p.4380-4388

1998

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Parallel supercritical fluid chromatography/mass spectrometry system for high-throughput enantioselective optimization and separation

Journal of Chromatography A, 2007-10, Vol.1169 (1), p.193-204

2007

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Automated high throughput ADME assays for metabolic stability and cytochrome P450 inhibition profiling of combinatorial libraries

Journal of pharmaceutical and biomedical analysis, 2004-03, Vol.34 (5), p.989-1004

2004

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Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors

Bioorganic & medicinal chemistry, 2008-04, Vol.18 (7), p.2362-2367

2008

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Development of a High-Throughput Online Solid-Phase Extraction/Tandem Mass Spectrometry Method for Cytochrome P450 Inhibition Screening

Journal of biomolecular screening, 2010-04, Vol.15 (4), p.447-452

2010

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Parallel SFC/MS-MUX screening to assess enantiomeric purity

Chirality (New York, N.Y.), 2008-08, Vol.20 (8), p.885-895

2008

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Discovery of Alogliptin: A Potent, Selective, Bioavailable, and Efficacious Inhibitor of Dipeptidyl Peptidase IV

Journal of medicinal chemistry, 2008-07, Vol.51 (14), p.4357-4357

2008

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Application of parallel liquid chromatography/mass spectrometry for high throughput microsomal stability screening of compound libraries

Journal of the American Society for Mass Spectrometry, 2002-02, Vol.13 (2), p.155-165

2002

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High-throughput mass spectrometric cytochrome P450 inhibition screening

Methods in molecular biology (Clifton, N.J.), 2013, Vol.987, p.25

2013

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High-Throughput Mass-Directed Parallel Purification Incorporating a Multiplexed Single Quadrupole Mass Spectrometer

Analytical chemistry (Washington), 2002-07, Vol.74 (13), p.3055-3062

2002

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Improvement of "hit-to-lead" optimization by integration of in vitro HTS experimental models for early determination of pharmacokinetic properties

Combinatorial chemistry & high throughput screening, 2002-09, Vol.5 (6), p.459-472

2002

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Substrate specificity and novel selective inhibitors of TNF-alpha converting enzyme (TACE) from two-dimensional substrate mapping

Combinatorial chemistry & high throughput screening, 2005-06, Vol.8 (4), p.327-339

2005

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Mass-directed fractionation and isolation of pharmaceutical compounds by packed-column supercritical fluid chromatography/mass spectrometry

Rapid communications in mass spectrometry, 2001-01, Vol.15 (22), p.2067-2075

2001

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In Vitro Phosphorylation of the Epidermal Growth Factor Receptor Autophosphorylation Domain by c-src: Identification of Phosphorylation Sites and c-src SH2 Domain Binding Sites

Biochemistry (Easton), 1995-12, Vol.34 (50), p.16456-16466

1995

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Fragmentation of tunichrome Sp-1 is dominated by an unusual gas-phase intramolecular rearrangement

Journal of mass spectrometry., 2003-10, Vol.38 (10), p.1105-1109

2003

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Differences in phosphorylation of human and chicken stathmin by MAP kinase

Journal of cellular biochemistry, 2001-03, Vol.80 (3), p.346-352

2001

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Differentiation of hydroxyproline isomers and isobars in peptides by tandem mass spectrometry

Analytical chemistry (Washington), 1990-08, Vol.62 (15), p.1691-1695

1990

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Discovery of Alogliptin: A Potent, Selective, Bioavailable, and Efficacious Inhibitor of Dipeptidyl Peptidase IV

Applications of high-throughput ADME in drug discovery

Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV

Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptidyl peptidase-4, in rats, dogs, and monkeys

Two-dimensional supercritical fluid chromatography/mass spectrometry for the enantiomeric analysis and purification of pharmaceutical samples

Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation

A high throughput metabolic stability screening workflow with automated assessment of data quality in pharmaceutical industry

Phosphopeptides enrichment using on-line two-dimensional strong cation exchange followed by reversed-phase liquid chromatography/mass spectrometry

Developments of a Fully Automated Parallel HPLC/Mass Spectrometry System for the Analytical Characterization and Preparative Purification of Combinatorial Libraries

Parallel supercritical fluid chromatography/mass spectrometry system for high-throughput enantioselective optimization and separation

Automated high throughput ADME assays for metabolic stability and cytochrome P450 inhibition profiling of combinatorial libraries

Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors

Development of a High-Throughput Online Solid-Phase Extraction/Tandem Mass Spectrometry Method for Cytochrome P450 Inhibition Screening

Parallel SFC/MS-MUX screening to assess enantiomeric purity

Discovery of Alogliptin: A Potent, Selective, Bioavailable, and Efficacious Inhibitor of Dipeptidyl Peptidase IV

Application of parallel liquid chromatography/mass spectrometry for high throughput microsomal stability screening of compound libraries

High-throughput mass spectrometric cytochrome P450 inhibition screening

High-Throughput Mass-Directed Parallel Purification Incorporating a Multiplexed Single Quadrupole Mass Spectrometer

Improvement of "hit-to-lead" optimization by integration of in vitro HTS experimental models for early determination of pharmacokinetic properties

Substrate specificity and novel selective inhibitors of TNF-alpha converting enzyme (TACE) from two-dimensional substrate mapping

Mass-directed fractionation and isolation of pharmaceutical compounds by packed-column supercritical fluid chromatography/mass spectrometry

In Vitro Phosphorylation of the Epidermal Growth Factor Receptor Autophosphorylation Domain by c-src: Identification of Phosphorylation Sites and c-src SH2 Domain Binding Sites

Fragmentation of tunichrome Sp-1 is dominated by an unusual gas-phase intramolecular rearrangement

Differences in phosphorylation of human and chicken stathmin by MAP kinase

Differentiation of hydroxyproline isomers and isobars in peptides by tandem mass spectrometry

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