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Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

Pharmacological reviews, 2020-04, Vol.72 (2), p.486-526

2020

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Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment

International journal of molecular sciences, 2018-08, Vol.19 (8), p.2299

2018

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Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer

Oncogene, 2015-03, Vol.34 (11), p.1341-1353

2015

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Blockade of the PD-1/PD-L1 Immune Checkpoint Pathway Improves Infection Outcomes and Enhances Fungicidal Host Defense in a Murine Model of Invasive Pulmonary Mucormycosis

Frontiers in immunology, 2022-02, Vol.13, p.838344-838344

2022

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Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma

Oncotarget, 2016-05, Vol.7 (18), p.26307-26330

2016

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Chemical probes that competitively and selectively inhibit Stat3 activation

PloS one, 2009-03, Vol.4 (3), p.e4783

2009

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Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer

Lung cancer (Amsterdam, Netherlands), 2015-11, Vol.90 (2), p.182-190

2015

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Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions

Biophysical journal, 2016-06, Vol.110 (11), p.2377-2385

2016

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Aberrant function of pathogenic STAT3 mutant proteins is linked to altered stability of monomers and homodimers

Blood, 2023-03, Vol.141 (12), p.1411-1424

2023

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TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain

Biochemical pharmacology, 2021-10, Vol.192, p.114688-114688, Article 114688

2021

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Pharmacokinetics and pharmacodynamics of TTI-101, a STAT3 inhibitor that blocks muscle proteolysis in rats with chronic kidney disease

American journal of physiology. Renal physiology, 2020-07, Vol.319 (1), p.F84-F92

2020

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Monoclonal Antibodies Specific for STAT3β Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer

Cancers, 2014-09, Vol.6 (4), p.2012-2034

2014

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Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome

Blood, 2016-12, Vol.128 (26), p.3061-3072

2016

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SH2 domain binding to phosphopeptide ligands: potential for drug targeting

Frontiers in bioscience (Landmark. Print), 2009-01, Vol.14 (3), p.1010

2009

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Novel STAT3 small-molecule inhibitors identified by structure-based virtual ligand screening incorporating SH2 domain flexibility

Pharmacological research, 2021-07, Vol.169, p.105637-105637, Article 105637

2021

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Targeting STAT3 anti-apoptosis pathways with organic and hybrid organic-inorganic inhibitors

Organic & biomolecular chemistry, 2020-05, Vol.18 (17), p.3288-3296

2020

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Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity

Angewandte Chemie (International ed.), 2015-10, Vol.54 (44), p.13085-13089

International ed. in English, 2015

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Correction: Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma

Oncotarget, 2019-02, Vol.10 (16), p.1603-1603

2019

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Signal Transducer and Activator of Transcription (Stat)3 Signaling and Targeting for Treatment and Prevention of Non-small Cell Lung Cancer

Chest, 2014-10, Vol.146 (4), p.586A-586A

2014

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B62 MOLECULAR INSIGHTS INTO LUNG CANCER I: Signal Transducer And Activator Of Transcription (stat) 3 Signaling And Targeting For Treatment And Prevention Of Non-Small Cell Lung Cancer

American journal of respiratory and critical care medicine, 2014-01, Vol.189, p.1

2014

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Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity

Angewandte Chemie, 2015-10, Vol.127 (44), p.13277-13281

2015

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3-D Pharmacophore Identification of Second Generation Small Molecule Inhibitors of Stat3 SH2-Phosphotyrosine Binding That Induce Apoptosis in Acute Myeloid Leukemia Cells

Blood, 2009-11, Vol.114 (22), p.1727-1727

2009

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Contribution of chaperones to STAT pathway signaling

JAK-STAT, 2014-07, Vol.3 (3), p.e970459-e970459

2014

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Monoclonal Antibodies Specific for STAT3[beta] Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer

Cancers, 2014-12, Vol.6 (4), p.2012

2014

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Interactions of the dynein intermediate chain subunit and structural characterization of pH induced monomer of the dynein light chain, LC8

Kasembeli, Moses M

2004

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Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment

Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer

Blockade of the PD-1/PD-L1 Immune Checkpoint Pathway Improves Infection Outcomes and Enhances Fungicidal Host Defense in a Murine Model of Invasive Pulmonary Mucormycosis

Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma

Chemical probes that competitively and selectively inhibit Stat3 activation

Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer

Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions

Aberrant function of pathogenic STAT3 mutant proteins is linked to altered stability of monomers and homodimers

TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain

Pharmacokinetics and pharmacodynamics of TTI-101, a STAT3 inhibitor that blocks muscle proteolysis in rats with chronic kidney disease

Monoclonal Antibodies Specific for STAT3β Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer

Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome

SH2 domain binding to phosphopeptide ligands: potential for drug targeting

Novel STAT3 small-molecule inhibitors identified by structure-based virtual ligand screening incorporating SH2 domain flexibility

Targeting STAT3 anti-apoptosis pathways with organic and hybrid organic-inorganic inhibitors

Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity

Correction: Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma

Signal Transducer and Activator of Transcription (Stat)3 Signaling and Targeting for Treatment and Prevention of Non-small Cell Lung Cancer

B62 MOLECULAR INSIGHTS INTO LUNG CANCER I: Signal Transducer And Activator Of Transcription (stat) 3 Signaling And Targeting For Treatment And Prevention Of Non-Small Cell Lung Cancer

Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity

3-D Pharmacophore Identification of Second Generation Small Molecule Inhibitors of Stat3 SH2-Phosphotyrosine Binding That Induce Apoptosis in Acute Myeloid Leukemia Cells

Contribution of chaperones to STAT pathway signaling

Monoclonal Antibodies Specific for STAT3[beta] Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer

Interactions of the dynein intermediate chain subunit and structural characterization of pH induced monomer of the dynein light chain, LC8

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