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Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease

The Journal of biological chemistry, 2012-11, Vol.287 (49), p.41245-41257

2012

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New Aminoimidazoles as β‑Secretase (BACE-1) Inhibitors Showing Amyloid‑β (Aβ) Lowering in Brain

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9297-9311

2012

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Discovery of USP7 small-molecule allosteric inhibitors

Bioorganic & medicinal chemistry letters, 2020-10, Vol.30 (20), p.127471-127471, Article 127471

2020

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Design and Synthesis of β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors with in Vivo Brain Reduction of β‑Amyloid Peptides

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9346-9361

2012

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Suzuki-Miyaura and Related Cross-Couplings in Aqueous Solvents Catalyzed by Di(2-pyridyl)methylamine-Palladium Dichloride Complexes

Advanced synthesis & catalysis, 2004-12, Vol.346 (13-15), p.1798-1811

2004

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AZ-4217: a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice

The Journal of neuroscience, 2013-06, Vol.33 (24), p.10075-10084

2013

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Biotransformation of two β-secretase inhibitors including ring opening and contraction of a pyrimidine ring

Drug metabolism and disposition, 2013-05, Vol.41 (5), p.1134-1147

2013

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Di-2-pyridylmethylamine-Based Palladium Complexes as New Catalysts for Heck, Suzuki, and Sonogashira Reactions in Organic and Aqueous Solvents

Organic letters, 2003-05, Vol.5 (9), p.1451-1454

2003

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Substituted 7‑Amino-5-thio-thiazolo[4,5‑d]pyrimidines as Potent and Selective Antagonists of the Fractalkine Receptor (CX3CR1)

Journal of medicinal chemistry, 2013-04, Vol.56 (8), p.3177-3190

2013

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Abstract 3011: Development of selective small-molecule inhibitors of cellular MALT1 protease activity

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.3011-3011

2016

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Correction to New Aminoimidazoles as β‑Secretase (BACE-1) Inhibitors Showing Amyloid‑β (Aβ) Lowering in Brain

Journal of medicinal chemistry, 2012-11, Vol.55 (22), p.10316-10316

2012

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Allylic Phosphates and Allylic Phosphinates as Electrophiles in Efficient Silylcupration Reactions of Acetylenes

Journal of organic chemistry, 2002-04, Vol.67 (7), p.2136-2143

2002

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Di(2-pyridyl)methylamine–palladium dichloride complex covalently anchored to a styrene-maleic anhydride co-polymer as recoverable catalyst for C–C cross-coupling reactions in water

Tetrahedron, 2005-12, Vol.61 (51), p.12168-12176

2005

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Nickel-Catalyzed Cross-Coupling of Dienyl Phosphates with Grignard Reagents in the Synthesis of 2-Substituted 1,3-Dienes

Journal of organic chemistry, 1999-03, Vol.64 (5), p.1745-1749

1999

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Silylcupration of Allenes and Subsequent Electrophilic Trapping by Allylic Phosphates. A Novel Approach to Silylated 1,4-Diene Systems

Organic letters, 2000-05, Vol.2 (9), p.1237-1239

2000

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A Versatile Route to 2-Substituted Cyclic 1,3-Dienes via a Copper(I)-Catalyzed Cross-Coupling Reaction of Dienyl Triflates with Grignard Reagents

Journal of organic chemistry, 1998-04, Vol.63 (8), p.2517-2522

1998

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P1‐241: In vivo reduction of beta‐amyloid peptides in the brain of Tg2576 mice after oral administration of a novel BACE1 inhibitor

Alzheimer's & dementia, 2012-07, Vol.8 (4S_Part_5), p.P191-P191

2012

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In vivo reduction of beta-amyloid peptides in the brain of Tg2576 mice after oral administration of a novel BACE1 inhibitor

Alzheimer's & dementia, 2012-07, Vol.8 (4), p.P191-P191

2012

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Ferrocenyl Thiolates as Ligands in the Enantioselective Copper-Catalyzed Substitution of Allylic Acetates with Grignard Reagents

Synlett, 2001, Vol.2001 (Special Issue), p.0923-0926

2001

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A Versatile Route to 2-Substituted Cyclic 1,3-dienes via a Copper(I)-Catalyzed Cross-Coupling Reaction of Dienyl Triflates with Grignard Reagents

Journal of organic chemistry, 1998-04, Vol.63 (8), p.2784-2784

1998

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Asymmetric Induction in the Arenethiolatocopper(I)-Catalyzed Substitution Reaction of Grignard Reagents with Allylic Substrates

Tetrahedron, 2000-04, Vol.56 (18), p.2895-2903

2000

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Experimental Evidence Supporting a CuIII Intermediate in Cross-Coupling Reactions of Allylic Esters with Diallylcuprate Species

Chemistry : a European journal, 2001-05, Vol.7 (9), p.1981-1989

2001

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Very Urgent Carotid Endarterectomy Confers Increased Procedural Risk

Stroke (1970), 2012-05, Vol.43 (5), p.1331-1335

2012

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Copper‐Mediated Enantioselective Substitution Reactions

Modern Organocopper Chemistry, 2002, p.259-288

2002

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Radionuclide Therapy of HER2-Expressing Human Xenografts Using Affibody-Based Peptide Nucleic Acid-Mediated Pretargeting: In Vivo Proof of Principle

Journal of Nuclear Medicine, 2018-07, Vol.59 (7), p.1092-1098

2018

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Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease

New Aminoimidazoles as β‑Secretase (BACE-1) Inhibitors Showing Amyloid‑β (Aβ) Lowering in Brain

Discovery of USP7 small-molecule allosteric inhibitors

Design and Synthesis of β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors with in Vivo Brain Reduction of β‑Amyloid Peptides

Suzuki-Miyaura and Related Cross-Couplings in Aqueous Solvents Catalyzed by Di(2-pyridyl)methylamine-Palladium Dichloride Complexes

AZ-4217: a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice

Biotransformation of two β-secretase inhibitors including ring opening and contraction of a pyrimidine ring

Di-2-pyridylmethylamine-Based Palladium Complexes as New Catalysts for Heck, Suzuki, and Sonogashira Reactions in Organic and Aqueous Solvents

Substituted 7‑Amino-5-thio-thiazolo[4,5‑d]pyrimidines as Potent and Selective Antagonists of the Fractalkine Receptor (CX3CR1)

Abstract 3011: Development of selective small-molecule inhibitors of cellular MALT1 protease activity

Correction to New Aminoimidazoles as β‑Secretase (BACE-1) Inhibitors Showing Amyloid‑β (Aβ) Lowering in Brain

Allylic Phosphates and Allylic Phosphinates as Electrophiles in Efficient Silylcupration Reactions of Acetylenes

Di(2-pyridyl)methylamine–palladium dichloride complex covalently anchored to a styrene-maleic anhydride co-polymer as recoverable catalyst for C–C cross-coupling reactions in water

Nickel-Catalyzed Cross-Coupling of Dienyl Phosphates with Grignard Reagents in the Synthesis of 2-Substituted 1,3-Dienes

Silylcupration of Allenes and Subsequent Electrophilic Trapping by Allylic Phosphates. A Novel Approach to Silylated 1,4-Diene Systems

A Versatile Route to 2-Substituted Cyclic 1,3-Dienes via a Copper(I)-Catalyzed Cross-Coupling Reaction of Dienyl Triflates with Grignard Reagents

P1‐241: In vivo reduction of beta‐amyloid peptides in the brain of Tg2576 mice after oral administration of a novel BACE1 inhibitor

In vivo reduction of beta-amyloid peptides in the brain of Tg2576 mice after oral administration of a novel BACE1 inhibitor

Ferrocenyl Thiolates as Ligands in the Enantioselective Copper-Catalyzed Substitution of Allylic Acetates with Grignard Reagents

A Versatile Route to 2-Substituted Cyclic 1,3-dienes via a Copper(I)-Catalyzed Cross-Coupling Reaction of Dienyl Triflates with Grignard Reagents

Asymmetric Induction in the Arenethiolatocopper(I)-Catalyzed Substitution Reaction of Grignard Reagents with Allylic Substrates

Experimental Evidence Supporting a CuIII Intermediate in Cross-Coupling Reactions of Allylic Esters with Diallylcuprate Species

Very Urgent Carotid Endarterectomy Confers Increased Procedural Risk

Copper‐Mediated Enantioselective Substitution Reactions

Radionuclide Therapy of HER2-Expressing Human Xenografts Using Affibody-Based Peptide Nucleic Acid-Mediated Pretargeting: In Vivo Proof of Principle

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