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Role of NOTCH3 Mutations in the Cerebral Small Vessel Disease Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

Stroke (1970), 2018-11, Vol.49 (11), p.2793-2800

2018

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Specificity of presenilin‐1‐ and presenilin‐2‐dependent γ‐secretases towards substrate processing

Journal of cellular and molecular medicine, 2018-02, Vol.22 (2), p.823-833

2018

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Molecular Chaperone BRICHOS Inhibits CADASIL-Mutated NOTCH3 Aggregation In Vitro

Frontiers in molecular biosciences, 2022-02, Vol.9, p.812808-812808

2022

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Visualizing active enzyme complexes using a photoreactive inhibitor for proximity ligation--application on γ-secretase

PloS one, 2013-05, Vol.8 (5), p.e63962

2013

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A CADASIL-Mutated Notch 3 Receptor Exhibits Impaired Intracellular Trafficking and Maturation but Normal Ligand-Induced Signaling

Proceedings of the National Academy of Sciences - PNAS, 2002-12, Vol.99 (26), p.17119-17124

2002

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Generalized Potential of Adult Neural Stem Cells

Science (American Association for the Advancement of Science), 2000-06, Vol.288 (5471), p.1660-1663

2000

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Molecular anatomy of adult mouse leptomeninges

Neuron (Cambridge, Mass.), 2023-12, Vol.111 (23), p.3745-3764.e7

2023

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Mutations in Nicastrin Protein Differentially Affect Amyloid β-Peptide Production and Notch Protein Processing

The Journal of biological chemistry, 2011-09, Vol.286 (36), p.31153-31158

2011

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Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain

Biochemical and biophysical research communications, 2011-01, Vol.404 (1), p.564-568

2011

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gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes

PloS one, 2010-03, Vol.5 (3), p.e9772-e9772

2010

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Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration-motor neuron disease

Annals of neurology, 2010-11, Vol.68 (5), p.639-649

2010

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Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model

EMBO molecular medicine, 2023-02, Vol.15 (2), p.e16556-n/a

2023

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The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent Notch signaling and increased PDGFRB expression

Disease models & mechanisms, 2021-02, Vol.14 (2)

2021

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Biochemical studies of poly-T variants in the Alzheimer's disease associated TOMM40 gene

Journal of Alzheimer's disease, 2012-01, Vol.31 (3), p.527-536

2012

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A Sensitive and Quantitative Assay for Measuring Cleavage of Presenilin Substrates

The Journal of biological chemistry, 2002-03, Vol.277 (9), p.6763-6766

2002

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Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations

FEBS open bio, 2014-01, Vol.4 (1), p.393-406

2014

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γ-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42) /Aβ(40) ratio

Journal of cellular and molecular medicine, 2011-10, Vol.15 (10), p.2150-2163

2011

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Mitofusin‐2 knockdown increases ER–mitochondria contact and decreases amyloid β‐peptide production

Journal of cellular and molecular medicine, 2016-09, Vol.20 (9), p.1686-1695

2016

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γ‐Secretase modulators show selectivity for γ‐secretase–mediated amyloid precursor protein intramembrane processing

Journal of cellular and molecular medicine, 2022-02, Vol.26 (3), p.880-892

2022

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A robust and efficient microvascular isolation method for multimodal characterization of the mouse brain vasculature

Cell reports methods, 2023-03, Vol.3 (3), p.100431-100431, Article 100431

2023

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O4-03-05: A molecular investigation of different domains in the gamma-secretase complex for their substrate interaction

Alzheimer's & dementia, 2008-07, Vol.4 (4), p.T189-T190

2008

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Differences in proliferation rate between CADASIL and control vascular smooth muscle cells are related to increased TGFβ expression

Journal of cellular and molecular medicine, 2018-06, Vol.22 (6), p.3016-3024

2018

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Presenilin dependence of phospholipase C and protein kinase C signaling

Journal of neurochemistry, 2007-08, Vol.102 (3), p.848-857

2007

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Novel Cysteine-Sparing Hypomorphic NOTCH3 A1604T Mutation Observed in a Family With Migraine and White Matter Lesions

Neurology. Genetics, 2021-06, Vol.7 (3), p.e584-e584

2021

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Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy

The Journal of neuroscience, 2012-11, Vol.32 (48), p.17297-17305

2012

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Role of NOTCH3 Mutations in the Cerebral Small Vessel Disease Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

Specificity of presenilin‐1‐ and presenilin‐2‐dependent γ‐secretases towards substrate processing

Molecular Chaperone BRICHOS Inhibits CADASIL-Mutated NOTCH3 Aggregation In Vitro

Visualizing active enzyme complexes using a photoreactive inhibitor for proximity ligation--application on γ-secretase

A CADASIL-Mutated Notch 3 Receptor Exhibits Impaired Intracellular Trafficking and Maturation but Normal Ligand-Induced Signaling

Generalized Potential of Adult Neural Stem Cells

Molecular anatomy of adult mouse leptomeninges

Mutations in Nicastrin Protein Differentially Affect Amyloid β-Peptide Production and Notch Protein Processing

Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain

gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes

Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration-motor neuron disease

Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model

The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent Notch signaling and increased PDGFRB expression

Biochemical studies of poly-T variants in the Alzheimer's disease associated TOMM40 gene

A Sensitive and Quantitative Assay for Measuring Cleavage of Presenilin Substrates

Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations

γ-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42) /Aβ(40) ratio

Mitofusin‐2 knockdown increases ER–mitochondria contact and decreases amyloid β‐peptide production

γ‐Secretase modulators show selectivity for γ‐secretase–mediated amyloid precursor protein intramembrane processing

A robust and efficient microvascular isolation method for multimodal characterization of the mouse brain vasculature

O4-03-05: A molecular investigation of different domains in the gamma-secretase complex for their substrate interaction

Differences in proliferation rate between CADASIL and control vascular smooth muscle cells are related to increased TGFβ expression

Presenilin dependence of phospholipase C and protein kinase C signaling

Novel Cysteine-Sparing Hypomorphic NOTCH3 A1604T Mutation Observed in a Family With Migraine and White Matter Lesions

Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy

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