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Cancer and cyclooxygenase-2 (COX-2) inhibition

Current pharmaceutical design, 2004-01, Vol.10 (6), p.627-634

2004

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Characterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts

Gastroenterology (New York, N.Y. 1943), 1996-08, Vol.111 (2), p.445-454

1996

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Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer

Cancer research (Chicago, Ill.), 1995-06, Vol.55 (12), p.2556-2559

1995

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Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes

American journal of respiratory and critical care medicine, 2001, Vol.163 (1), p.226-233

2001

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Receptor for Motilin Identified in the Human Gastrointestinal System

Science (American Association for the Advancement of Science), 1999-06, Vol.284 (5423), p.2184-2188

1999

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The discovery of rofecoxib, [MK 966, VIOXX ®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5 H)-furanone], an orally active cyclooxygenase-2 inhibitor

Bioorganic & medicinal chemistry letters, 1999-07, Vol.9 (13), p.1773-1778

1999

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Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX‐2 inhibitor

British journal of pharmacology, 1997-05, Vol.121 (1), p.105-117

1997

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A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase inhibitors

Inflammation research, 1996-02, Vol.45 (2), p.68-74

1996

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Translocation of 5-lipoxygenase to the membrane in human leukocytes challenged with ionophore A23187

The Journal of biological chemistry, 1988-08, Vol.263 (22), p.10980-10988

1988

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Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid

Molecular pharmacology, 1994-02, Vol.45 (2), p.245-254

1994

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Cloning of the cDNA for Human 5-lipoxygenase

Proceedings of the National Academy of Sciences - PNAS, 1988-01, Vol.85 (2), p.416-420

1988

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From indomethacin to a selective COX-2 inhibitor: Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors

Bioorganic & medicinal chemistry letters, 1996-03, Vol.6 (6), p.725-730

1996

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Characterization of the human cysteinyl leukotriene CysLT1 receptor

Nature (London), 1999-06, Vol.399 (6738), p.789-793

1999

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Correlation between expression of 5-lipoxygenase-activating protein, 5-lipoxygenase, and cellular leukotriene synthesis

The Journal of biological chemistry, 1990-11, Vol.265 (32), p.19818-19823

1990

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Inhibition of cyclooxygenase-2 by rofecoxib attenuates the growth and metastatic potential of colorectal carcinoma in mice

Cancer research (Chicago, Ill.), 2003-02, Vol.63 (3), p.586-592

2003

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Cytosolic phospholipase A2, cyclo-oxygenases and arachidonate in human stomach tumours

European journal of cancer (1990), 1997-08, Vol.33 (9), p.1508-1512

1997

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Translocation of HL-60 cell 5-lipoxygenase. Inhibition of A23187- or N-formyl-methionyl-leucyl-phenylalanine-induced translocation by indole and quinoline leukotriene synthesis inhibitors

The Journal of biological chemistry, 1991-12, Vol.266 (35), p.23745-23752

1991

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Studies on the Regulation, Biosynthesis, and Activation of 5-Lipoxygenase in Differentiated HL60 Cells

The Journal of biological chemistry, 1989-08, Vol.264 (22), p.13313-13320

1989

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Maintenance of Caspase-3 Proenzyme Dormancy by an Intrinsic "Safety Catch" Regulatory Tripeptide

Proceedings of the National Academy of Sciences - PNAS, 2001-05, Vol.98 (11), p.6132-6137

2001

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A new series of selective COX-2 inhibitors: 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles

Bioorganic & medicinal chemistry letters, 1997-01, Vol.7 (1), p.57-62

1997

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Synthesis and biological evaluation of both enantiomers of L-761,000 as inhibitors of cyclooxygenase 1 and 2

Bioorganic & medicinal chemistry letters, 1996-03, Vol.6 (6), p.731-736

1996

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Characterization of autocrine inducible prostaglandin H synthase-2 (PGHS-2) in human osteosarcoma cells

Inflammation research, 1997-02, Vol.46 (2), p.51-59

1997

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Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles

The Journal of pharmacology and experimental therapeutics, 1999-08, Vol.290 (2), p.551

1999

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The C3a receptor antagonist SB 290157 has agonist activity

Immunology Letters, 2005-09, Vol.100 (2), p.139-145

2005

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Gob-5 Is Not Essential for Mucus Overproduction in Preclinical Murine Models of Allergic Asthma

American journal of respiratory cell and molecular biology, 2005-09, Vol.33 (3), p.303-314

2005

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Cancer and cyclooxygenase-2 (COX-2) inhibition

Characterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts

Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer

Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes

Receptor for Motilin Identified in the Human Gastrointestinal System

The discovery of rofecoxib, [MK 966, VIOXX ®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5 H)-furanone], an orally active cyclooxygenase-2 inhibitor

Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX‐2 inhibitor

A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase inhibitors

Translocation of 5-lipoxygenase to the membrane in human leukocytes challenged with ionophore A23187

Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid

Cloning of the cDNA for Human 5-lipoxygenase

From indomethacin to a selective COX-2 inhibitor: Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors

Characterization of the human cysteinyl leukotriene CysLT1 receptor

Correlation between expression of 5-lipoxygenase-activating protein, 5-lipoxygenase, and cellular leukotriene synthesis

Inhibition of cyclooxygenase-2 by rofecoxib attenuates the growth and metastatic potential of colorectal carcinoma in mice

Cytosolic phospholipase A2, cyclo-oxygenases and arachidonate in human stomach tumours

Translocation of HL-60 cell 5-lipoxygenase. Inhibition of A23187- or N-formyl-methionyl-leucyl-phenylalanine-induced translocation by indole and quinoline leukotriene synthesis inhibitors

Studies on the Regulation, Biosynthesis, and Activation of 5-Lipoxygenase in Differentiated HL60 Cells

Maintenance of Caspase-3 Proenzyme Dormancy by an Intrinsic "Safety Catch" Regulatory Tripeptide

A new series of selective COX-2 inhibitors: 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles

Synthesis and biological evaluation of both enantiomers of L-761,000 as inhibitors of cyclooxygenase 1 and 2

Characterization of autocrine inducible prostaglandin H synthase-2 (PGHS-2) in human osteosarcoma cells

Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles

The C3a receptor antagonist SB 290157 has agonist activity

Gob-5 Is Not Essential for Mucus Overproduction in Preclinical Murine Models of Allergic Asthma

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