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Results of the Surveillance of Tedizolid Activity and Resistance Program: in vitro susceptibility of Gram-positive pathogens collected in 2011 and 2012 from the United States and Europe

Diagnostic microbiology and infectious disease, 2015-02, Vol.81 (2), p.112-118

2015

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Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agents

PloS one, 2013-12, Vol.8 (12), p.e84409-e84409

2013

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Amicoumacin A Inhibits Translation by Stabilizing mRNA Interaction with the Ribosome

Molecular cell, 2014-11, Vol.56 (4), p.531-540

2014

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Low Fitness Cost of the Multidrug Resistance Gene cfr

Antimicrobial Agents and Chemotherapy, 2011-08, Vol.55 (8), p.3714-3719

2011

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Calcineurin Inhibitors Synergize with Manogepix to Kill Diverse Human Fungal Pathogens

Journal of fungi (Basel), 2022-10, Vol.8 (10), p.1102

2022

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In Vitro and In Vivo Evaluation of the Antifungal Activity of APX001A/APX001 against Candida auris

Antimicrobial agents and chemotherapy, 2018-03, Vol.62 (3)

2018

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Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis

Antimicrobial agents and chemotherapy, 2020-02, Vol.64 (3)

2020

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APX001 Is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis

Antimicrobial agents and chemotherapy, 2019-02, Vol.63 (2)

2019

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Safety and Pharmacokinetics of Intravenous and Oral Fosmanogepix, a First-in-Class Antifungal Agent, in Healthy Volunteers

Antimicrobial agents and chemotherapy, 2023-04, Vol.67 (4), p.e0162322-e0162322

2023

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Efficacy of Delayed Therapy with Fosmanogepix (APX001) in a Murine Model of Candida auris Invasive Candidiasis

Antimicrobial agents and chemotherapy, 2019-11, Vol.63 (11)

2019

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Manogepix, the Active Moiety of the Investigational Agent Fosmanogepix, Demonstrates In Vitro Activity against Members of the Fusarium oxysporum and Fusarium solani Species Complexes

Antimicrobial agents and chemotherapy, 2021-05, Vol.65 (6)

2021

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Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition

Nucleic acids research, 2013-08, Vol.41 (14), p.e144-e144

2013

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Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity

Bioorganic & medicinal chemistry letters, 2013-03, Vol.23 (5), p.1529-1536

2013

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Detection of the High-Level Aminoglycoside Resistance Gene aph(2")-Ib in Enterococcus faecium

Antimicrobial Agents and Chemotherapy, 2000-10, Vol.44 (10), p.2876-2879

2000

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Analysis of Commercial Kidney Stone Probiotic Supplements

Urology (Ridgewood, N.J.), 2015-03, Vol.85 (3), p.517-521

2015

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Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: Development of inhibitors with broad spectrum, Gram-negative antibacterial activity

Bioorganic & medicinal chemistry letters, 2013-03, Vol.23 (5), p.1537-1543

2013

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Linezolid-resistant Staphylococcus aureus strain 1128105, the first known clinical isolate possessing the cfr multidrug resistance gene

Antimicrobial agents and chemotherapy, 2014-11, Vol.58 (11), p.6592-6598

2014

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Identification of Bacteria-Selective Threonyl-tRNA Synthetase Substrate Inhibitors by Structure-Based Design

Journal of medicinal chemistry, 2013-02, Vol.56 (4), p.1748-1760

2013

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Identification and characterization of linezolid-resistant cfr-positive Staphylococcus aureus USA300 isolates from a New York City medical center

Antimicrobial agents and chemotherapy, 2014-11, Vol.58 (11), p.6949-6952

2014

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Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines

Bioorganic & medicinal chemistry letters, 2011-09, Vol.21 (18), p.5171-5176

2011

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Distinguishing on-target versus off-target activity in early antibacterial drug discovery using a macromolecular synthesis assay

Journal of biomolecular screening, 2013-10, Vol.18 (9), p.1018-1026

2013

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Evernimicin Binds Exclusively to the 50S Ribosomal Subunit and Inhibits Translation in Cell-Free Systems Derived from both Gram-Positive and Gram-Negative Bacteria

Antimicrobial Agents and Chemotherapy, 2000-05, Vol.44 (5), p.1121-1126

2000

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Evernimicin (SCH27899) Inhibits a Novel Ribosome Target Site: Analysis of 23S Ribosomal DNA Mutants

Antimicrobial Agents and Chemotherapy, 2000-11, Vol.44 (11), p.3101-3106

2000

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Mutations in Ribosomal Protein L16 Conferring Reduced Susceptibility to Evernimicin (SCH27899): Implications for Mechanism of Action

Antimicrobial Agents and Chemotherapy, 2000-03, Vol.44 (3), p.732-738

2000

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Genomics and antimicrobial drug discovery

Antimicrobial agents and chemotherapy, 1999-03, Vol.43 (3), p.439-446

1999

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Results of the Surveillance of Tedizolid Activity and Resistance Program: in vitro susceptibility of Gram-positive pathogens collected in 2011 and 2012 from the United States and Europe

Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agents

Amicoumacin A Inhibits Translation by Stabilizing mRNA Interaction with the Ribosome

Low Fitness Cost of the Multidrug Resistance Gene cfr

Calcineurin Inhibitors Synergize with Manogepix to Kill Diverse Human Fungal Pathogens

In Vitro and In Vivo Evaluation of the Antifungal Activity of APX001A/APX001 against Candida auris

Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis

APX001 Is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis

Safety and Pharmacokinetics of Intravenous and Oral Fosmanogepix, a First-in-Class Antifungal Agent, in Healthy Volunteers

Efficacy of Delayed Therapy with Fosmanogepix (APX001) in a Murine Model of Candida auris Invasive Candidiasis

Manogepix, the Active Moiety of the Investigational Agent Fosmanogepix, Demonstrates In Vitro Activity against Members of the Fusarium oxysporum and Fusarium solani Species Complexes

Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity

Detection of the High-Level Aminoglycoside Resistance Gene aph(2")-Ib in Enterococcus faecium

Analysis of Commercial Kidney Stone Probiotic Supplements

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: Development of inhibitors with broad spectrum, Gram-negative antibacterial activity

Linezolid-resistant Staphylococcus aureus strain 1128105, the first known clinical isolate possessing the cfr multidrug resistance gene

Identification of Bacteria-Selective Threonyl-tRNA Synthetase Substrate Inhibitors by Structure-Based Design

Identification and characterization of linezolid-resistant cfr-positive Staphylococcus aureus USA300 isolates from a New York City medical center

Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines

Distinguishing on-target versus off-target activity in early antibacterial drug discovery using a macromolecular synthesis assay

Evernimicin Binds Exclusively to the 50S Ribosomal Subunit and Inhibits Translation in Cell-Free Systems Derived from both Gram-Positive and Gram-Negative Bacteria

Evernimicin (SCH27899) Inhibits a Novel Ribosome Target Site: Analysis of 23S Ribosomal DNA Mutants

Mutations in Ribosomal Protein L16 Conferring Reduced Susceptibility to Evernimicin (SCH27899): Implications for Mechanism of Action

Genomics and antimicrobial drug discovery

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