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A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa

Nature medicine, 2013-04, Vol.19 (4), p.446-451

2013

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Comparison of reversal activity and mechanism of action of UHRA, andexanet, and PER977 on heparin and oral FXa inhibitors

Blood advances, 2018-08, Vol.2 (16), p.2104-2114

2018

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A phase 2 PK/PD study of andexanet alfa for reversal of rivaroxaban and edoxaban anticoagulation in healthy volunteers

Blood advances, 2020-02, Vol.4 (4), p.728-739

2020

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Heteroarylureas with spirocyclic diamine cores as inhibitors of fatty acid amide hydrolase

Bioorganic & medicinal chemistry letters, 2014-02, Vol.24 (3), p.737-741

2014

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Biochemical and Biological Properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a Mechanism-Based Inhibitor of Fatty Acid Amide Hydrolase

Anesthesia and analgesia, 2009, Vol.108 (1), p.316-329

2009

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Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase

Bioorganic & medicinal chemistry, 2008-09, Vol.18 (17), p.4838-4843

2008

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1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase

Bioorganic & medicinal chemistry letters, 2014-03, Vol.24 (5), p.1280-1284

2014

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Interaction of Group IA Phospholipase A2 with Metal Ions and Phospholipid Vesicles Probed with Deuterium Exchange Mass Spectrometry

Biochemistry (Easton), 2008-06, Vol.47 (24), p.6451-6459

2008

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Purification and Characterization of the Lipid A 1-Phosphatase LpxE of Rhizobium leguminosarum

The Journal of biological chemistry, 2009-01, Vol.284 (1), p.414-425

2009

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Periplasmic Cleavage and Modification of the 1-Phosphate Group of Helicobacter pylori Lipid A

The Journal of biological chemistry, 2004-12, Vol.279 (53), p.55780-55791

2004

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MsbA transporter-dependent lipid A 1-dephosphorylation on the periplasmic surface of the inner membrane: topography of francisella novicida LpxE expressed in Escherichia coli

The Journal of biological chemistry, 2004-11, Vol.279 (47), p.49470-49478

2004

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Expression Cloning and Biochemical Characterization of a Rhizobium leguminosarum Lipid A 1-Phosphatase

The Journal of biological chemistry, 2003-10, Vol.278 (41), p.39269-39279

2003

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Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structure–mutagenicity relationships for arylamine metabolites

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (24), p.7357-7362

2012

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Expression Cloning and Characterization of the C28 Acyltransferase of Lipid A Biosynthesis in Rhizobium leguminosarum

The Journal of biological chemistry, 2002-08, Vol.277 (32), p.28959-28971

2002

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Enzymatic synthesis of lipid A molecules with four amide-linked acyl chains. LpxA acyltransferases selective for an analog of UDP-N-acetylglucosamine in which an amine replaces the 3"-hydroxyl group

The Journal of biological chemistry, 2004-06, Vol.279 (24), p.25411-25419

2004

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Origin of the 2-amino-2-deoxy-gluconate unit in Rhizobium leguminosarum lipid A. Expression cloning of the outer membrane oxidase LpxQ

The Journal of biological chemistry, 2003-04, Vol.278 (14), p.12120-12129

2003

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Heteroarylureas with fused bicyclic diamine cores as inhibitors of fatty acid amide hydrolase

Bioorganic & medicinal chemistry letters, 2020-10, Vol.30 (20), p.127463-127463, Article 127463

2020

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Andexanet Alfa Reverses Anticoagulation Effects of Enoxaparin and Associated Bleeding in a Rabbit Acute Hemorrhage Model

Blood, 2016-12, Vol.128 (22), p.1445-1445

2016

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Preclinical Characterization of the FAAH Inhibitor JNJ-42165279

ACS medicinal chemistry letters, 2015-12, Vol.6 (12), p.1204-1208

2015

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Safety, pharmacokinetics, and reversal of apixaban anticoagulation with andexanet alfa

Blood advances, 2017-09, Vol.1 (21), p.1827-1838

2017

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A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial Demonstrating Reversal Of Rivaroxaban-Induced Anticoagulation In Healthy Subjects By Andexanet Alfa (PRT064445), An Antidote For Fxa Inhibitors

Blood, 2013-11, Vol.122 (21), p.3636-3636

2013

Volltextzugriff (PDF)

MsbA Transporter-dependent Lipid A 1-Dephosphorylation on the Periplasmic Surface of the Inner Membrane

The Journal of biological chemistry, 2004-11, Vol.279 (47), p.49470-49478

2004

Volltextzugriff (PDF)

Purification and Characterization of the Lipid A 1-Phosphatase LpxE of Rhizobium leguminosarumS

The Journal of biological chemistry, 2009-01, Vol.284 (1), p.414-425

2009

Volltextzugriff (PDF)

Enzymatic Synthesis of Lipid A Molecules with Four Amide-linked Acyl Chains

The Journal of biological chemistry, 2004-06, Vol.279 (24), p.25411-25419

2004

Volltextzugriff (PDF)

Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate

ACS medicinal chemistry letters, 2012-10, Vol.3 (10), p.823-827

2012

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A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa

Comparison of reversal activity and mechanism of action of UHRA, andexanet, and PER977 on heparin and oral FXa inhibitors

A phase 2 PK/PD study of andexanet alfa for reversal of rivaroxaban and edoxaban anticoagulation in healthy volunteers

Heteroarylureas with spirocyclic diamine cores as inhibitors of fatty acid amide hydrolase

Biochemical and Biological Properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a Mechanism-Based Inhibitor of Fatty Acid Amide Hydrolase

Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase

1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase

Interaction of Group IA Phospholipase A2 with Metal Ions and Phospholipid Vesicles Probed with Deuterium Exchange Mass Spectrometry

Purification and Characterization of the Lipid A 1-Phosphatase LpxE of Rhizobium leguminosarum

Periplasmic Cleavage and Modification of the 1-Phosphate Group of Helicobacter pylori Lipid A

MsbA transporter-dependent lipid A 1-dephosphorylation on the periplasmic surface of the inner membrane: topography of francisella novicida LpxE expressed in Escherichia coli

Expression Cloning and Biochemical Characterization of a Rhizobium leguminosarum Lipid A 1-Phosphatase

Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structure–mutagenicity relationships for arylamine metabolites

Expression Cloning and Characterization of the C28 Acyltransferase of Lipid A Biosynthesis in Rhizobium leguminosarum

Enzymatic synthesis of lipid A molecules with four amide-linked acyl chains. LpxA acyltransferases selective for an analog of UDP-N-acetylglucosamine in which an amine replaces the 3"-hydroxyl group

Origin of the 2-amino-2-deoxy-gluconate unit in Rhizobium leguminosarum lipid A. Expression cloning of the outer membrane oxidase LpxQ

Heteroarylureas with fused bicyclic diamine cores as inhibitors of fatty acid amide hydrolase

Andexanet Alfa Reverses Anticoagulation Effects of Enoxaparin and Associated Bleeding in a Rabbit Acute Hemorrhage Model

Preclinical Characterization of the FAAH Inhibitor JNJ-42165279

Safety, pharmacokinetics, and reversal of apixaban anticoagulation with andexanet alfa

A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial Demonstrating Reversal Of Rivaroxaban-Induced Anticoagulation In Healthy Subjects By Andexanet Alfa (PRT064445), An Antidote For Fxa Inhibitors

MsbA Transporter-dependent Lipid A 1-Dephosphorylation on the Periplasmic Surface of the Inner Membrane

Purification and Characterization of the Lipid A 1-Phosphatase LpxE of Rhizobium leguminosarumS

Enzymatic Synthesis of Lipid A Molecules with Four Amide-linked Acyl Chains

Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate

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