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Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors/Antioxidants as Promising Drugs for the Treatment of Diabetic Complications

Molecules (Basel, Switzerland), 2021-05, Vol.26 (10), p.2867

2021

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Triglyceride-lowering effect of the aldose reductase inhibitor cemtirestat—another factor that may contribute to attenuation of symptoms of peripheral neuropathy in STZ-diabetic rats

Naunyn-Schmiedeberg's archives of pharmacology, 2020-04, Vol.393 (4), p.651-661

2020

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A dual-acting aldose reductase inhibitor impedes oxidative and carbonyl stress in tissues of fructose- and streptozotocin-induced rats: comparison with antioxidant stobadine

Drug and chemical toxicology (New York, N.Y. 1978), 2024-09, Vol.47 (5), p.710-720

2024

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Carbonyl stress in aging process: role of vitamins and phytochemicals as redox regulators

Aging and disease, 2013-10, Vol.4 (5), p.276-294

2013

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Bacopa Monnieri Protects the Directly Affected Organ as Well as Distant Organs Against I/R Injury by Modulating Anti-Inflammatory and Anti-Nitrosative Pathways in A Rat Model for Infra-Renal Aortic Occlusion

Journal of investigative surgery, 2021-09, Vol.34 (9), p.935-946

2021

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Oleuropein and rutin protect against 6-OHDA-induced neurotoxicity in PC12 cells through modulation of mitochondrial function and unfolded protein response

Interdisciplinary toxicology, 2017-12, Vol.10 (4), p.129-141

2017

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Effects of olive leaf polyphenols against H₂O₂ toxicity in insulin secreting β-cells

Acta biochimica Polonica, 2011-01, Vol.58 (1), p.45

2011

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Protection against α-Amanitin-induced liver toxicity: Efficacy of pomegranate seed oil and black cumin oil

Toxicon (Oxford), 2024-08, Vol.247, p.107854, Article 107854

2024

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Glycoxidative stress and cardiovascular complications in experimentally-induced diabetes: effects of antioxidant treatment

The open cardiovascular medicine journal, 2010-11, Vol.4 (1), p.240-256

Karasu, Cimen

2010

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Carboxymethylated pyridoindole antioxidants as aldose reductase inhibitors: Synthesis, activity, partitioning, and molecular modeling

Bioorganic & medicinal chemistry, 2008-05, Vol.16 (9), p.4908-4920

2008

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Redox status related activation of endoplasmic reticulum stress and apoptosis caused by 4-hydroxynonenal exposure in INS-1 cells

Toxicology mechanisms and methods, 2014-06, Vol.24 (5), p.362-367

2014

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Platinum nanoparticles Protect Against Lipopolysaccharide-Induced Inflammation in Microglial BV-2 Cells via Decreased Oxidative Damage and Increased Phagocytosis

Neurochemical research, 2021-12, Vol.46 (12), p.3325-3341

2021

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Cemtirestat, an aldose reductase inhibitor and antioxidant compound, induces ocular defense against oxidative and inflammatory stress in rat models for glycotoxicity

Cell biochemistry and function, 2023-08, Vol.41 (6), p.622-632

2023

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Cannabinoid-profiled agents improve cell survival via reduction of oxidative stress and inflammation, and Nrf2 activation in a toxic model combining hyperglycemia+Aβ1-42 peptide in rat hippocampal neurons

Neurochemistry international, 2020-11, Vol.140, p.104817-104817, Article 104817

2020

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Graphene- and MXene-based materials for neuroscience: diagnostic and therapeutic applications

Biomaterials science, 2023-10, Vol.11 (2), p.6687-671

2023

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Redox-active phytoconstituents ameliorate cell damage and inflammation in rat hippocampal neurons exposed to hyperglycemia+Aβ1-42 peptide

Neurochemistry international, 2021-05, Vol.145, p.104993, Article 104993

2021

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Eye lens in aging and diabetes: effect of quercetin

Rejuvenation research, 2011-10, Vol.14 (5), p.525-534

2011

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Olive leaf extracts protect cardiomyocytes against 4-hydroxynonenal-induced toxicity in vitro: comparison with oleuropein, hydroxytyrosol, and quercetin

Planta medica, 2014-08, Vol.80 (12), p.984-992

2014

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S -allylcysteine inhibits chondrocyte inflammation to reduce human osteoarthritis via targeting RAGE, TLR4, JNK, and Nrf2 signaling: comparison with colchicine

Biochemistry and cell biology, 2021-09, Vol.99 (5), p.645-654

2021

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Monoacylglycerol Lipase Inhibition Prevents Short-Term Mitochondrial Dysfunction and Oxidative Damage in Rat Brain Synaptosomal/Mitochondrial Fractions and Cortical Slices: Role of Cannabinoid Receptors

Neurotoxicity research, 2023-12, Vol.41 (6), p.514-525

2023

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The Pharmacological Inhibition of Fatty Acid Amide Hydrolase Prevents Excitotoxic Damage in the Rat Striatum: Possible Involvement of CB1 Receptors Regulation

Molecular neurobiology, 2019-02, Vol.56 (2), p.844-856

2019

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Tackling chronic wound healing using nanomaterials: advancements, challenges, and future perspectives

Applied materials today, 2023-06, Vol.32, p.101829, Article 101829

2023

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URB597 Prevents the Short-Term Excitotoxic Cell Damage in Rat Cortical Slices: Role of Cannabinoid 1 Receptors

Neurotoxicity research, 2021-04, Vol.39 (2), p.146-155

2021

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Luteolin protects microglia against rotenone-induced toxicity in a hormetic manner through targeting oxidative stress response, genes associated with Parkinson's disease and inflammatory pathways

Drug and chemical toxicology (New York, N.Y. 1978), 2020-01, Vol.43 (1), p.96-103

2020

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STOBADINE PROTECTS RAT KIDNEY AGAINST ISCHAEMIA/REPERFUSION INJURY

Clinical and experimental pharmacology & physiology, 2007-03, Vol.34 (3), p.210-216

2007

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Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors/Antioxidants as Promising Drugs for the Treatment of Diabetic Complications

Triglyceride-lowering effect of the aldose reductase inhibitor cemtirestat—another factor that may contribute to attenuation of symptoms of peripheral neuropathy in STZ-diabetic rats

A dual-acting aldose reductase inhibitor impedes oxidative and carbonyl stress in tissues of fructose- and streptozotocin-induced rats: comparison with antioxidant stobadine

Carbonyl stress in aging process: role of vitamins and phytochemicals as redox regulators

Bacopa Monnieri Protects the Directly Affected Organ as Well as Distant Organs Against I/R Injury by Modulating Anti-Inflammatory and Anti-Nitrosative Pathways in A Rat Model for Infra-Renal Aortic Occlusion

Oleuropein and rutin protect against 6-OHDA-induced neurotoxicity in PC12 cells through modulation of mitochondrial function and unfolded protein response

Effects of olive leaf polyphenols against H₂O₂ toxicity in insulin secreting β-cells

Protection against α-Amanitin-induced liver toxicity: Efficacy of pomegranate seed oil and black cumin oil

Glycoxidative stress and cardiovascular complications in experimentally-induced diabetes: effects of antioxidant treatment

Carboxymethylated pyridoindole antioxidants as aldose reductase inhibitors: Synthesis, activity, partitioning, and molecular modeling

Redox status related activation of endoplasmic reticulum stress and apoptosis caused by 4-hydroxynonenal exposure in INS-1 cells

Platinum nanoparticles Protect Against Lipopolysaccharide-Induced Inflammation in Microglial BV-2 Cells via Decreased Oxidative Damage and Increased Phagocytosis

Cemtirestat, an aldose reductase inhibitor and antioxidant compound, induces ocular defense against oxidative and inflammatory stress in rat models for glycotoxicity

Cannabinoid-profiled agents improve cell survival via reduction of oxidative stress and inflammation, and Nrf2 activation in a toxic model combining hyperglycemia+Aβ1-42 peptide in rat hippocampal neurons

Graphene- and MXene-based materials for neuroscience: diagnostic and therapeutic applications

Redox-active phytoconstituents ameliorate cell damage and inflammation in rat hippocampal neurons exposed to hyperglycemia+Aβ1-42 peptide

Eye lens in aging and diabetes: effect of quercetin

Olive leaf extracts protect cardiomyocytes against 4-hydroxynonenal-induced toxicity in vitro: comparison with oleuropein, hydroxytyrosol, and quercetin

S -allylcysteine inhibits chondrocyte inflammation to reduce human osteoarthritis via targeting RAGE, TLR4, JNK, and Nrf2 signaling: comparison with colchicine

Monoacylglycerol Lipase Inhibition Prevents Short-Term Mitochondrial Dysfunction and Oxidative Damage in Rat Brain Synaptosomal/Mitochondrial Fractions and Cortical Slices: Role of Cannabinoid Receptors

The Pharmacological Inhibition of Fatty Acid Amide Hydrolase Prevents Excitotoxic Damage in the Rat Striatum: Possible Involvement of CB1 Receptors Regulation

Tackling chronic wound healing using nanomaterials: advancements, challenges, and future perspectives

URB597 Prevents the Short-Term Excitotoxic Cell Damage in Rat Cortical Slices: Role of Cannabinoid 1 Receptors

Luteolin protects microglia against rotenone-induced toxicity in a hormetic manner through targeting oxidative stress response, genes associated with Parkinson's disease and inflammatory pathways

STOBADINE PROTECTS RAT KIDNEY AGAINST ISCHAEMIA/REPERFUSION INJURY

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