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The impact of microwave synthesis on drug discovery

Nature reviews. Drug discovery, 2006-01, Vol.5 (1), p.51-63

2006

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Microwaves in organic and medicinal chemistry

Volume 25., 2005

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Novel pyrazole compounds for pharmacological discrimination between receptor‐operated and store‐operated Ca2+ entry pathways

British journal of pharmacology, 2012-12, Vol.167 (8), p.1712-1722

2012

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Controlled Microwave Heating in Modern Organic Synthesis

Angewandte Chemie (International ed.), 2004-11, Vol.43 (46), p.6250-6284

Kappe, C. Oliver

2004

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Recent Advances in the Biginelli Dihydropyrimidine Synthesis. New Tricks from an Old Dog

Accounts of chemical research, 2000-12, Vol.33 (12), p.879-888

Kappe, C. Oliver

2000

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Biologically active dihydropyrimidones of the Biginelli-type — a literature survey

European Journal of Medicinal Chemistry, 2000-12, Vol.35 (12), p.1043-1052

Kappe, C.Oliver

2000

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High-speed combinatorial synthesis utilizing microwave irradiation

Current Opinion in Chemical Biology, 2002-06, Vol.6 (3), p.314-320

Kappe, C.Oliver

2002

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A Reexamination of the Mechanism of the Biginelli Dihydropyrimidine Synthesis. Support for an N-Acyliminium Ion Intermediate(1)

Journal of organic chemistry, 1997-10, Vol.62 (21), p.7201-7204

Kappe, C. Oliver

1997

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Tunable Carbon−Carbon and Carbon−Sulfur Cross-Coupling of Boronic Acids with 3,4-Dihydropyrimidine-2-thiones

Organic letters, 2004-03, Vol.6 (5), p.771-774

2004

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Rapid microwave-assisted solution phase synthesis of substituted 2-pyridone libraries

Tetrahedron, 2004-09, Vol.60 (39), p.8633-8644

2004

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100 years of the biginelli dihydropyrimidine synthesis

Tetrahedron, 1993-08, Vol.49 (32), p.6937-6963

Oliver Kappe, C.

1993

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Microwave-assisted Negishi and Kumada cross-coupling reactions of aryl chlorides

Chemical communications (Cambridge, England), 2004-03 (5), p.564-565

2004

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Microwave-assisted solution phase synthesis of dihydropyrimidine C5 amides and esters

Tetrahedron, 2006-05, Vol.62 (19), p.4651-4664

2006

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Microwave-Assisted Multistep Synthesis of Functionalized 4-Arylquinolin-2(1H)-ones Using Palladium-Catalyzed Cross-Coupling Chemistry

Journal of organic chemistry, 2005-05, Vol.70 (10), p.3864-3870

2005

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Microwave-Assisted Ring-Closing Metathesis Revisited. On the Question of the Nonthermal Microwave Effect

Journal of organic chemistry, 2003-11, Vol.68 (23), p.9136-9139

2003

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High-Throughput Synthesis of N3-Acylated Dihydropyrimidines Combining Microwave-Assisted Synthesis and Scavenging Techniques

Organic letters, 2003-04, Vol.5 (8), p.1205-1208

2003

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Solid- and solution-phase synthesis of bioactive dihydropyrimidines

Pure and applied chemistry, 2004-01, Vol.76 (5), p.1017-1024

2004

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Synthetic applications of furan Diels-Alder chemistry

Tetrahedron, 1997-10, Vol.53 (42), p.14179-14233

1997

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Microwave-Assisted High-Speed Parallel Synthesis of 4-Aryl-3,4-dihydropyrimidin-2(1H)-ones using a Solventless Biginelli Condensation Protocol

Synthesis (Stuttgart), 1999-10, Vol.1999 (10), p.1799-1803

Kappe, C. Oliver

1999

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Monolithic polymer/carrier materials: Versatile composites for fine chemical synthesis

Catalysis today, 2005-08, Vol.105 (3), p.318-324

2005

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High-Speed Couplings and Cleavages in Microwave-Heated, Solid-Phase Reactions at High Temperatures

European journal of organic chemistry, 2001-03, Vol.2001 (5), p.919-925

2001

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Polyphosphate Ester-Mediated Synthesis of Dihydropyrimidines. Improved Conditions for the Biginelli Reaction

Synlett, 1998-07, Vol.1998 (7), p.718-720

1998

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Rapid Formation of Triarylphosphines by Microwave-Assisted Transition Metal-Catalyzed C−P Cross-Coupling Reactions

Organic letters, 2002-10, Vol.4 (20), p.3541-3543

2002

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4-Aryldihydropyrimidines via the Biginelli Condensation: Aza-Analogs of Nifedipine-Type Calcium Channel Modulators

Molecules, 1998-01, Vol.3 (1), p.1-9

Kappe, C. Oliver

1998

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Scalability of Microwave-Assisted Organic Synthesis. From Single-Mode to Multimode Parallel Batch Reactors

Organic process research & development, 2003-09, Vol.7 (5), p.707-716

2003

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The impact of microwave synthesis on drug discovery

Microwaves in organic and medicinal chemistry

Novel pyrazole compounds for pharmacological discrimination between receptor‐operated and store‐operated Ca2+ entry pathways

Controlled Microwave Heating in Modern Organic Synthesis

Recent Advances in the Biginelli Dihydropyrimidine Synthesis. New Tricks from an Old Dog

Biologically active dihydropyrimidones of the Biginelli-type — a literature survey

High-speed combinatorial synthesis utilizing microwave irradiation

A Reexamination of the Mechanism of the Biginelli Dihydropyrimidine Synthesis. Support for an N-Acyliminium Ion Intermediate(1)

Tunable Carbon−Carbon and Carbon−Sulfur Cross-Coupling of Boronic Acids with 3,4-Dihydropyrimidine-2-thiones

Rapid microwave-assisted solution phase synthesis of substituted 2-pyridone libraries

100 years of the biginelli dihydropyrimidine synthesis

Microwave-assisted Negishi and Kumada cross-coupling reactions of aryl chlorides

Microwave-assisted solution phase synthesis of dihydropyrimidine C5 amides and esters

Microwave-Assisted Multistep Synthesis of Functionalized 4-Arylquinolin-2(1H)-ones Using Palladium-Catalyzed Cross-Coupling Chemistry

Microwave-Assisted Ring-Closing Metathesis Revisited. On the Question of the Nonthermal Microwave Effect

High-Throughput Synthesis of N3-Acylated Dihydropyrimidines Combining Microwave-Assisted Synthesis and Scavenging Techniques

Solid- and solution-phase synthesis of bioactive dihydropyrimidines

Synthetic applications of furan Diels-Alder chemistry

Microwave-Assisted High-Speed Parallel Synthesis of 4-Aryl-3,4-dihydropyrimidin-2(1H)-ones using a Solventless Biginelli Condensation Protocol

Monolithic polymer/carrier materials: Versatile composites for fine chemical synthesis

High-Speed Couplings and Cleavages in Microwave-Heated, Solid-Phase Reactions at High Temperatures

Polyphosphate Ester-Mediated Synthesis of Dihydropyrimidines. Improved Conditions for the Biginelli Reaction

Rapid Formation of Triarylphosphines by Microwave-Assisted Transition Metal-Catalyzed C−P Cross-Coupling Reactions

4-Aryldihydropyrimidines via the Biginelli Condensation: Aza-Analogs of Nifedipine-Type Calcium Channel Modulators

Scalability of Microwave-Assisted Organic Synthesis. From Single-Mode to Multimode Parallel Batch Reactors

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