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Hepatitis A Virus Infection in Cynomolgus Monkeys Confounds the Safety Evaluation of a Drug Candidate

International journal of toxicology, 2024-08, Vol.43 (4), p.368-376

2024

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Practical Considerations in Determining Adversity and the No-Observed-Adverse-Effect-Level (NOAEL) in Nonclinical Safety Studies: Challenges, Perspectives and Case Studies

International Journal of Toxicology, 2022-03, Vol.41 (2), p.143-162

2022

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Abstract 12419: Preclinical Safety and Efficacy of a Novel Thrombolytic Agent Administered by Rapid Bolus Injection: Clot Specific Streptokinase (CSSK/SMRX-11)

Circulation (New York, N.Y.), 2015-11, Vol.132 (Suppl_3 Suppl 3), p.A12419-A12419

2015

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Overview of Drug Development and Nonclinical Safety: Role of the Toxicologic Pathologist and Regulatory Aspects

Toxicologic Pathology, 2024, Vol.1, p.14-37

1, 2024

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The role of experimental toxicology in safety evaluation: Challenges facing the pharmaceutical industry

Medicinal research reviews, 1990-04, Vol.10 (2), p.271-280

1990

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The effects of glucose on ascorbic acid uptake in heart endothelial cells: Possible pathogenesis of diabetic angiopathies

Life sciences (1973), 1984-01, Vol.34 (6), p.577-584

1984

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Selected physical and biochemical parameters in the streptozotocin-treated guinea pig: Insights into the diabetic guinea pig model

Life sciences (1973), 1987-09, Vol.41 (11), p.1345-1353

1987

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Lack of Neuronal Vacuolation and Necrosis in Monkeys Treated with Selfotel (CGS 19755), A Competitive N-methyl-D-aspartate Receptor Antagonist

International journal of toxicology, 1997-03, Vol.16 (2), p.175-181

1997

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Effects of potassium or potassium/magnesium supplementation on potassium content of body tissues and fluids in furosemide-treated rats on magnesium-deficient or magnesium-sufficient diet

Life sciences (1973), 1990, Vol.46 (1), p.19-27

1990

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Effects of streptozotocin in the male guinea pig: A potential animal model for studying diabetes

Life sciences (1973), 1984-08, Vol.35 (6), p.649-655

1984

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THE DESCRIPTION AND EVALUATION OF A MULTICHAMBER EXPOSURE SYSTEM: SELECTED TOXIC EFFECTS OF AMMONIA IN MICE

KAPEGHIAN, JOHN CURTIS

1981

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A compact multichamber gas inhalation exposure system for mice

Toxicology letters, 1985-01, Vol.24 (2), p.179-186

1985

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Effects of Primaquine on Serum Biochemical and Hematological Parameters in Anesthetized Macaca fascicularis

Journal of medical primatology, 1984-01, Vol.13 (2), p.97-103

1984

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Effects of ammonia on selected hepatic microsomal enzyme activity in mice

Bulletin of environmental contamination and toxicology, 1985-07, Vol.35 (1), p.15-22

1985

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Changes in Selected Serum Biochemical and EKG Values With Age in Cynomolgus Macaques

Journal of medical primatology, 1984, Vol.13 (5), p.283-288

1984

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Effect of dietary protein on locomotor activity during chronic lead exposure in male and female rats

Bulletin of environmental contamination and toxicology, 1983-02, Vol.30 (2), p.158-164

1983

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Alteration of the disruptive effect of fenfluramine on food consumption in the rat by repeated post-session administration of d-amphetamine

Psychopharmacology, 1981-01, Vol.75 (4), p.358-362

1981

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Effect of the route of administration on microsomal enzyme induction following repeated administration of methadone in the mouse

Biochemical pharmacology, 1979-10, Vol.28 (19), p.3021-3025

1979

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Acute inhalation toxicity of ammonia in mice

Bulletin of environmental contamination and toxicology, 1982-09, Vol.29 (3), p.371-378

1982

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Evaluation of 2-azabicyclo[2.2.2]octane analogs of 4-anilidopiperidine analgesics

Journal of pharmaceutical sciences, 1980-09, Vol.69 (9), p.1104-1106

1980

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A simplified method for sampling atmospheric ammonia from inhalation chambers during exposure studies

Bulletin of environmental contamination and toxicology, 1981-08, Vol.27 (2), p.282-287

1981

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Evaluation of 2-Azabicyclo[2.2.2]loctane Analogs of 4-Anilidopiperidine Analgesics

Journal of pharmaceutical sciences, 1980-09, Vol.69 (9), p.1104-1106

1980

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Determination of Ascorbic Acid and Dehydroascorbic Acid in Blood Plasma Samples

Journal of liquid chromatography, 1983-06, Vol.6 (7), p.1319-1332

1983

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Hepatitis A Virus Infection in Cynomolgus Monkeys Confounds the Safety Evaluation of a Drug Candidate

Practical Considerations in Determining Adversity and the No-Observed-Adverse-Effect-Level (NOAEL) in Nonclinical Safety Studies: Challenges, Perspectives and Case Studies

Abstract 12419: Preclinical Safety and Efficacy of a Novel Thrombolytic Agent Administered by Rapid Bolus Injection: Clot Specific Streptokinase (CSSK/SMRX-11)

Overview of Drug Development and Nonclinical Safety: Role of the Toxicologic Pathologist and Regulatory Aspects

The role of experimental toxicology in safety evaluation: Challenges facing the pharmaceutical industry

The effects of glucose on ascorbic acid uptake in heart endothelial cells: Possible pathogenesis of diabetic angiopathies

Selected physical and biochemical parameters in the streptozotocin-treated guinea pig: Insights into the diabetic guinea pig model

Lack of Neuronal Vacuolation and Necrosis in Monkeys Treated with Selfotel (CGS 19755), A Competitive N-methyl-D-aspartate Receptor Antagonist

Effects of potassium or potassium/magnesium supplementation on potassium content of body tissues and fluids in furosemide-treated rats on magnesium-deficient or magnesium-sufficient diet

Effects of streptozotocin in the male guinea pig: A potential animal model for studying diabetes

THE DESCRIPTION AND EVALUATION OF A MULTICHAMBER EXPOSURE SYSTEM: SELECTED TOXIC EFFECTS OF AMMONIA IN MICE

A compact multichamber gas inhalation exposure system for mice

Effects of Primaquine on Serum Biochemical and Hematological Parameters in Anesthetized Macaca fascicularis

Effects of ammonia on selected hepatic microsomal enzyme activity in mice

Changes in Selected Serum Biochemical and EKG Values With Age in Cynomolgus Macaques

Effect of dietary protein on locomotor activity during chronic lead exposure in male and female rats

Alteration of the disruptive effect of fenfluramine on food consumption in the rat by repeated post-session administration of d-amphetamine

Effect of the route of administration on microsomal enzyme induction following repeated administration of methadone in the mouse

Acute inhalation toxicity of ammonia in mice

Evaluation of 2-azabicyclo[2.2.2]octane analogs of 4-anilidopiperidine analgesics

A simplified method for sampling atmospheric ammonia from inhalation chambers during exposure studies

Evaluation of 2-Azabicyclo[2.2.2]loctane Analogs of 4-Anilidopiperidine Analgesics

Determination of Ascorbic Acid and Dehydroascorbic Acid in Blood Plasma Samples

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