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Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation

Frontiers in neurology, 2021-01, Vol.11, p.595532

2021

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Progranulin Stimulates the In Vitro Maturation of Pro-Cathepsin D at Acidic pH

Journal of molecular biology, 2019-03, Vol.431 (5), p.1038-1047

2019

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Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response

PLoS genetics, 2019-08, Vol.15 (8), p.e1008295-e1008295

2019

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A shift to organismal stress resistance in programmed cell death mutants

PLoS genetics, 2013-09, Vol.9 (9), p.e1003714-e1003714

2013

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Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases

Molecular neurodegeneration, 2023-05, Vol.18 (1), p.29-29, Article 29

2023

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Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration

Molecular neurodegeneration, 2021-08, Vol.16 (1), p.51-51, Article 51

2021

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Protons in small spaces: Discrete simulations of vesicle acidification

PLoS computational biology, 2019-12, Vol.15 (12), p.e1007539-e1007539

2019

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Progranulin, lysosomal regulation and neurodegenerative disease

Nature reviews. Neuroscience, 2017-06, Vol.18 (6), p.325

2017

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neurodegenerative disease mutation that accelerates the clearance of apoptotic cells

Proceedings of the National Academy of Sciences - PNAS, 2011-03, Vol.108 (11), p.4441-4446

2011

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Progranulin Adsorbs to Polypropylene Tubes and Disrupts Functional Assays: Implications for Research, Biomarker Studies, and Therapeutics

Frontiers in neuroscience, 2020-12, Vol.14, p.602235-602235

2020

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The progranulin cleavage product granulin 3 exerts a dominant negative effect on animal fitness

Human molecular genetics, 2024-01, Vol.33 (3), p.245-253

2024

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Correction: Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases

Molecular neurodegeneration, 2023-05, Vol.18 (1), p.34-34

2023

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Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress

Human molecular genetics, 2018-11, Vol.27 (22), p.3951-3963

2018

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Multi-Granulin Domain Peptides Bind to Pro-Cathepsin D and Stimulate Its Enzymatic Activity More Effectively Than Progranulin in Vitro

Biochemistry (Easton), 2019-06, Vol.58 (23), p.2670-2674

2019

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Heavy metals contaminating the environment of a progressive supranuclear palsy cluster induce tau accumulation and cell death in cultured neurons

Scientific reports, 2020-01, Vol.10 (1), p.569, Article 569

2020

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Tuberous sclerosis complex is associated with a novel human tauopathy

Acta neuropathologica, 2023-01, Vol.145 (1), p.1-12

2023

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The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels

The Journal of neuroscience, 2015-06, Vol.35 (25), p.9315-9328

2015

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Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport

Human molecular genetics, 2019-05, Vol.28 (9), p.1498-1514

2019

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Association of Cognitive and Behavioral Features Between Adults With Tuberous Sclerosis and Frontotemporal Dementia

JAMA neurology, 2020-03, Vol.77 (3), p.358

2020

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Phenotypic Screening Using High-Content Imaging to Identify Lysosomal pH Modulators in a Neuronal Cell Model

ACS chemical neuroscience, 2022-05, Vol.13 (10), p.1505-1516

2022

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Second international symposium on the chaperone code, 2023

Cell stress & chaperones, 2024-02, Vol.29 (1), p.88-96

2024

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Cognitive and Neuropsychiatric Profile of the Synucleinopathies: Parkinson Disease, Dementia With Lewy Bodies, and Multiple System Atrophy

Alzheimer disease and associated disorders, 2009-10, Vol.23 (4), p.365-370

2009

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TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy

Science advances, 2021-11, Vol.7 (45), p.eabg3897-eabg3897

2021

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Linking tuberous sclerosis complex, excessive mTOR signaling, and age-related neurodegeneration: a new association between TSC1 mutation and frontotemporal dementia

Acta neuropathologica, 2017-11, Vol.134 (5), p.813-816

2017

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Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation

Progranulin Stimulates the In Vitro Maturation of Pro-Cathepsin D at Acidic pH

Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response

A shift to organismal stress resistance in programmed cell death mutants

Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases

Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration

Protons in small spaces: Discrete simulations of vesicle acidification

Progranulin, lysosomal regulation and neurodegenerative disease

A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies

neurodegenerative disease mutation that accelerates the clearance of apoptotic cells

Progranulin Adsorbs to Polypropylene Tubes and Disrupts Functional Assays: Implications for Research, Biomarker Studies, and Therapeutics

The progranulin cleavage product granulin 3 exerts a dominant negative effect on animal fitness

Correction: Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases

Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress

Multi-Granulin Domain Peptides Bind to Pro-Cathepsin D and Stimulate Its Enzymatic Activity More Effectively Than Progranulin in Vitro

Heavy metals contaminating the environment of a progressive supranuclear palsy cluster induce tau accumulation and cell death in cultured neurons

Tuberous sclerosis complex is associated with a novel human tauopathy

The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels

Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport

Association of Cognitive and Behavioral Features Between Adults With Tuberous Sclerosis and Frontotemporal Dementia

Phenotypic Screening Using High-Content Imaging to Identify Lysosomal pH Modulators in a Neuronal Cell Model

Second international symposium on the chaperone code, 2023

Cognitive and Neuropsychiatric Profile of the Synucleinopathies: Parkinson Disease, Dementia With Lewy Bodies, and Multiple System Atrophy

TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy

Linking tuberous sclerosis complex, excessive mTOR signaling, and age-related neurodegeneration: a new association between TSC1 mutation and frontotemporal dementia

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