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Predicting Solubility of Newly-Approved Drugs (2016–2020) with a Simple ABSOLV and GSE(Flexible-Acceptor) Consensus Model Outperforming Random Forest Regression

Journal of solution chemistry, 2022, Vol.51 (9), p.1020-1055

2022

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Trends in PhysChem Properties of Newly Approved Drugs over the Last Six Years; Predicting Solubility of Drugs Approved in 2021

Journal of solution chemistry, 2022-12, Vol.51 (12), p.1455-1481

2022

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Correction: Trends in PhysChem Properties of Newly Approved Drugs over the Last Six Years; Predicting Solubility of Drugs Approved in 2021

Journal of solution chemistry, 2022, Vol.51 (12), p.1482-1482

2022

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Coexistence of passive and carrier-mediated processes in drug transport

Nature reviews. Drug discovery, 2010-08, Vol.9 (8), p.597-614

2010

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Fluorine in Medicinal Chemistry

Chembiochem : a European journal of chemical biology, 2004-05, Vol.5 (5), p.637-643

2004

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Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties

Journal of medicinal chemistry, 2017-10, Vol.60 (19), p.8071-8082

2017

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Physicochemical High Throughput Screening: Parallel Artificial Membrane Permeation Assay in the Description of Passive Absorption Processes

Journal of medicinal chemistry, 1998-03, Vol.41 (7), p.1007-1010

1998

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PAMPA—critical factors for better predictions of absorption

Journal of pharmaceutical sciences, 2007-11, Vol.96 (11), p.2893-2909

2007

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Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

Drug discovery today, 2012-08, Vol.17 (15-16), p.905-912

2012

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Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

Molecular pharmaceutics, 2014-06, Vol.11 (6), p.1727-1738

2014

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On the polarity of partially fluorinated methyl groups

Journal of fluorine chemistry, 2013-08, Vol.152, p.119-128

2013

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Pharmacological Promiscuity: Dependence on Compound Properties and Target Specificity in a Set of Recent Roche Compounds

ChemMedChem, 2009-04, Vol.4 (4), p.680-686

2009

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Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities

ChemMedChem, 2007-08, Vol.2 (8), p.1100-1115

2007

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High throughput solubility measurement in drug discovery and development

Advanced drug delivery reviews, 2007-07, Vol.59 (7), p.546-567

2007

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“Flexible-Acceptor” General Solubility Equation for beyond Rule of 5 Drugs

Molecular pharmaceutics, 2020-10, Vol.17 (10), p.3930-3940

2020

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Quantifying the impact of transporters on cellular drug permeability

Trends in pharmacological sciences (Regular ed.), 2015-05, Vol.36 (5), p.255-262

2015

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Design, data analysis, and simulation of in vitro drug transport kinetic experiments using a mechanistic in vitro model

Drug metabolism and disposition, 2008-12, Vol.36 (12), p.2434-2444

2008

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Development of a Virtual Screening Method for Identification of “Frequent Hitters” in Compound Libraries

Journal of medicinal chemistry, 2002-01, Vol.45 (1), p.137-142

2002

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Advances in screening for membrane permeability: high-resolution PAMPA for medicinal chemists

Drug discovery today. Technologies, 2004-12, Vol.1 (4), p.349-355

2004

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Self-assembly, DNA Complexation, and pH Response of Amphiphilic Dendrimers for Gene Transfection

Langmuir, 2007-01, Vol.23 (2), p.737-746

2007

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pKa determination by 1H NMR spectroscopy – An old methodology revisited

Journal of pharmaceutical and biomedical analysis, 2014-05, Vol.93, p.147-155

2014

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Potent Inhibitors of tRNA-Guanine Transglycosylase, an Enzyme Linked to the Pathogenicity of the Shigella Bacterium: Charge-Assisted Hydrogen Bonding

Angewandte Chemie (International ed.), 2007, Vol.46 (43), p.8266-8269

2007

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Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery

Journal of medicinal chemistry, 2015-11, Vol.58 (22), p.9041-9060

2015

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Can small drugs predict the intrinsic aqueous solubility of 'beyond Rule of 5' big drugs?

ADMET & DMPK, 2020-01, Vol.8 (3), p.180-206

2020

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Extending pKa prediction accuracy: High-throughput pKa measurements to understand pKa modulation of new chemical series

European journal of medicinal chemistry, 2010-09, Vol.45 (9), p.4270-4279

2010

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Predicting Solubility of Newly-Approved Drugs (2016–2020) with a Simple ABSOLV and GSE(Flexible-Acceptor) Consensus Model Outperforming Random Forest Regression

Trends in PhysChem Properties of Newly Approved Drugs over the Last Six Years; Predicting Solubility of Drugs Approved in 2021

Correction: Trends in PhysChem Properties of Newly Approved Drugs over the Last Six Years; Predicting Solubility of Drugs Approved in 2021

Coexistence of passive and carrier-mediated processes in drug transport

Fluorine in Medicinal Chemistry

Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties

Physicochemical High Throughput Screening: Parallel Artificial Membrane Permeation Assay in the Description of Passive Absorption Processes

PAMPA—critical factors for better predictions of absorption

Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

On the polarity of partially fluorinated methyl groups

Pharmacological Promiscuity: Dependence on Compound Properties and Target Specificity in a Set of Recent Roche Compounds

Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities

High throughput solubility measurement in drug discovery and development

“Flexible-Acceptor” General Solubility Equation for beyond Rule of 5 Drugs

Quantifying the impact of transporters on cellular drug permeability

Design, data analysis, and simulation of in vitro drug transport kinetic experiments using a mechanistic in vitro model

Development of a Virtual Screening Method for Identification of “Frequent Hitters” in Compound Libraries

Advances in screening for membrane permeability: high-resolution PAMPA for medicinal chemists

Self-assembly, DNA Complexation, and pH Response of Amphiphilic Dendrimers for Gene Transfection

pKa determination by 1H NMR spectroscopy – An old methodology revisited

Potent Inhibitors of tRNA-Guanine Transglycosylase, an Enzyme Linked to the Pathogenicity of the Shigella Bacterium: Charge-Assisted Hydrogen Bonding

Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery

Can small drugs predict the intrinsic aqueous solubility of 'beyond Rule of 5' big drugs?

Extending pKa prediction accuracy: High-throughput pKa measurements to understand pKa modulation of new chemical series

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