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Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation

Nature communications, 2023-06, Vol.14 (1), p.3742-3742, Article 3742

2023

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Structural and Quantum Chemical Studies of 8-Aryl-sulfanyl Adenine Class Hsp90 Inhibitors

Journal of medicinal chemistry, 2006-08, Vol.49 (16), p.4953-4960

2006

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Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer

Nature chemical biology, 2007-08, Vol.3 (8), p.498-507

2007

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Microwave-assisted one step synthesis of 8-arylmethyl-9H-purin-6-amines

Bioorganic & medicinal chemistry letters, 2009-01, Vol.19 (2), p.415-417

2009

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Mechanism, Chemoselectivity, and Stereoselectivity of an NHC-Catalyzed Reaction of Aldehydes and Hydrazones: A DFT Study

The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory, 2024-05, Vol.128 (22), p.4483-4492

2024

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Sensing and Fixation of NO2/N2O4 by Calix[4]Arenes

Journal of the American Chemical Society, 2003-03, Vol.125 (10), p.2997-3007

2003

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Affinity Purification Probes of Potential Use To Investigate the Endogenous Hsp70 Interactome in Cancer

ACS chemical biology, 2014-08, Vol.9 (8), p.1698-1705

2014

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Synthesis of a red-shifted fluorescence polarization probe for Hsp90

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (17), p.4515-4518

2006

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Design of a fluorescence polarization assay platform for the study of human Hsp70

Bioorganic & medicinal chemistry, 2008-07, Vol.18 (13), p.3749-3751

2008

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A facile and efficient synthesis of d6-labeled PU-H71, a purine-scaffold Hsp90 inhibitor

Journal of labelled compounds & radiopharmaceuticals, 2010-01, Vol.53 (1), p.47-49

2010

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Polymer-supported calix[4]arenes for sensing and conversion of NO2/N2O4

Tetrahedron, , Vol.60 (49), p.11219-11225

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Mechanisms, regio- and stereoselectivities involved in NHCcatalyzed dearomatizing annulation of ester with ylide: A computational study

Molecular catalysis, 2024-05, Vol.560, Article 114146

2024

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Copper mediated coupling of 2-(piperazine)-pyrimidine iodides with aryl thiols using Cu(I)thiophene-2-carboxylate

Tetrahedron letters, 2017-11, Vol.58 (48), p.4525-4531

2017

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Heat Shock Protein 70 Inhibitors. 1. 2,5′-Thiodipyrimidine and 5‑(Phenylthio)pyrimidine Acrylamides as Irreversible Binders to an Allosteric Site on Heat Shock Protein 70

Journal of medicinal chemistry, 2014-02, Vol.57 (4), p.1188-1207

2014

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Heat Shock Protein 70 Inhibitors. 2. 2,5′-Thiodipyrimidines, 5‑(Phenylthio)pyrimidines, 2‑(Pyridin-3-ylthio)pyrimidines, and 3‑(Phenylthio)pyridines as Reversible Binders to an Allosteric Site on Heat Shock Protein 70

Journal of medicinal chemistry, 2014-02, Vol.57 (4), p.1208-1224

2014

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Load Sharing Behavior of Double-Pinion Planetary Gear Sets Considering Manufacturing Errors

IOP conference series. Materials Science and Engineering, 2019-12, Vol.677 (5), p.52068

2019

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Polymer-supported calix[4]arenes for sensing and conversion of NO 2/N 2O 4

Tetrahedron, 2004-11, Vol.60 (49), p.11219-11225

2004

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Discovery and development of purine-scaffold Hsp90 inhibitors

Expert opinion on drug discovery, 2008-01, Vol.3 (1), p.99-114

2008

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Abstract 3895: Rational design of small molecule inhibitors that bind to an allosteric pocket on human heat shock protein 70 (Hsp70)

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.3895-3895

2012

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The Apoptosis Related BIM Is An HSP70‐Specific Client Protein

The FASEB journal, 2012-04, Vol.26 (S1)

2012

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Abstract 1733: Development of chemical tools to study the endogenous Hsp70 interactome in malignant cells

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.1733-1733

2015

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Abstract 5444: Development of a noninvasive assay to determine drug concentration in tumor during hsp90 inhibitor therapy

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.5444-5444

2015

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Microwave-assisted one step synthesis of 8-arylmethyl-9 H-purin-6-amines

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (2), p.415-417

2009

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HSP70 Inhibitor, YK5, Ablates Blast, Progenitor and Stem Cell Populations in Primary Acute Myelogenous Leukemia Cells

Blood, 2011-11, Vol.118 (21), p.2493-2493

2011

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Abstract 2579: YK5, a small molecule inhibitor of Hsp70 and Hsc70, reveals a multifaceted role for the Hsp70 chaperones in regulating oncogenic and non-oncogenic addiction of tumors

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.2579-2579

2011

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Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation

Structural and Quantum Chemical Studies of 8-Aryl-sulfanyl Adenine Class Hsp90 Inhibitors

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer

Microwave-assisted one step synthesis of 8-arylmethyl-9H-purin-6-amines

Mechanism, Chemoselectivity, and Stereoselectivity of an NHC-Catalyzed Reaction of Aldehydes and Hydrazones: A DFT Study

Sensing and Fixation of NO2/N2O4 by Calix[4]Arenes

Affinity Purification Probes of Potential Use To Investigate the Endogenous Hsp70 Interactome in Cancer

Synthesis of a red-shifted fluorescence polarization probe for Hsp90

Design of a fluorescence polarization assay platform for the study of human Hsp70

A facile and efficient synthesis of d6-labeled PU-H71, a purine-scaffold Hsp90 inhibitor

Polymer-supported calix[4]arenes for sensing and conversion of NO2/N2O4

Mechanisms, regio- and stereoselectivities involved in NHCcatalyzed dearomatizing annulation of ester with ylide: A computational study

Copper mediated coupling of 2-(piperazine)-pyrimidine iodides with aryl thiols using Cu(I)thiophene-2-carboxylate

Heat Shock Protein 70 Inhibitors. 1. 2,5′-Thiodipyrimidine and 5‑(Phenylthio)pyrimidine Acrylamides as Irreversible Binders to an Allosteric Site on Heat Shock Protein 70

Heat Shock Protein 70 Inhibitors. 2. 2,5′-Thiodipyrimidines, 5‑(Phenylthio)pyrimidines, 2‑(Pyridin-3-ylthio)pyrimidines, and 3‑(Phenylthio)pyridines as Reversible Binders to an Allosteric Site on Heat Shock Protein 70

Load Sharing Behavior of Double-Pinion Planetary Gear Sets Considering Manufacturing Errors

Polymer-supported calix[4]arenes for sensing and conversion of NO 2/N 2O 4

Discovery and development of purine-scaffold Hsp90 inhibitors

Abstract 3895: Rational design of small molecule inhibitors that bind to an allosteric pocket on human heat shock protein 70 (Hsp70)

The Apoptosis Related BIM Is An HSP70‐Specific Client Protein

Abstract 1733: Development of chemical tools to study the endogenous Hsp70 interactome in malignant cells

Abstract 5444: Development of a noninvasive assay to determine drug concentration in tumor during hsp90 inhibitor therapy

Microwave-assisted one step synthesis of 8-arylmethyl-9 H-purin-6-amines

HSP70 Inhibitor, YK5, Ablates Blast, Progenitor and Stem Cell Populations in Primary Acute Myelogenous Leukemia Cells

Abstract 2579: YK5, a small molecule inhibitor of Hsp70 and Hsc70, reveals a multifaceted role for the Hsp70 chaperones in regulating oncogenic and non-oncogenic addiction of tumors

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