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Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic

Naunyn-Schmiedeberg's archives of pharmacology, 2016-10, Vol.389 (10), p.1133-1137

2016

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Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat

Toxicology letters, 2012-01, Vol.208 (1), p.62-68

2012

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Pentamidine-induced long QT syndrome and block of hERG trafficking

The Journal of pharmacology and experimental therapeutics, 2005-01, Vol.312 (1), p.316-323

2005

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A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs

European journal of pharmacology, 2002-08, Vol.450 (1), p.37-41

2002

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Discovery of a Small Molecule Activator of the Human Ether-a-go-go-Related Gene (HERG) Cardiac K+ Channel

Molecular pharmacology, 2005-03, Vol.67 (3), p.827-836

2005

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Interactions of a Series of Fluoroquinolone Antibacterial Drugs with the Human Cardiac K+ Channel HERG

Molecular pharmacology, 2001-01, Vol.59 (1), p.122-126

2001

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Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches

Bioorganic & medicinal chemistry letters, 2003-05, Vol.13 (10), p.1829-1835

2003

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Predictive models for hERG potassium channel blockers

Bioorganic & medicinal chemistry letters, 2005-08, Vol.15 (15), p.3637-3642

2005

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A β-tryptase inhibitor with a tropanylamide scaffold to improve in vitro stability and to lower hERG channel binding affinity

Bioorganic & medicinal chemistry letters, 2012-02, Vol.22 (4), p.1606-1610

2012

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A Novel Gene, hKCa4, Encodes the Calcium-activated Potassium Channel in Human T Lymphocytes

The Journal of biological chemistry, 1997-12, Vol.272 (52), p.32723-32726

1997

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Mechanisms underlying the QT interval-prolonging effects of sevoflurane and its interactions with other QT-prolonging drugs

Anesthesiology (Philadelphia), 2006-05, Vol.104 (5), p.1015-1022

2006

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High affinity blockade of the HERG cardiac K + channel by the neuroleptic pimozide

European journal of pharmacology, 2000-03, Vol.392 (3), p.137-140

2000

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Cardiac ion channel effects of tolterodine

The Journal of pharmacology and experimental therapeutics, 2004-03, Vol.308 (3), p.935-940

2004

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Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK and HERG

The Journal of pharmacology and experimental therapeutics, 2001-10, Vol.299 (1), p.290

2001

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Molecular determinants of loperamide and N-desmethyl loperamide binding in the hERG cardiac K+ channel

Bioorganic & medicinal chemistry letters, 2018-02, Vol.28 (3), p.446-451

2018

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L-type Ca2+ channel responses to bay k 8644 in stem cell-derived cardiomyocytes are unusually dependent on holding potential and charge carrier

Assay and drug development technologies, 2014-08, Vol.12 (6), p.352

2014

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Observations on conducting whole‐cell patch clamping of the hERG cardiac K+ channel in pure human serum

Journal of applied toxicology, 2017-04, Vol.37 (4), p.445-453

2017

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Observations on conducting whole-cell patch clamping of the hERG cardiac K super(+) channel in pure human serum

Journal of applied toxicology, 2017-04, Vol.37 (4), p.445-453

2017

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Ca²⁺ channel activators reveal differential L-type Ca²⁺ channel pharmacology between native and stem cell-derived cardiomyocytes

The Journal of pharmacology and experimental therapeutics, 2012-05, Vol.341 (2), p.510

2012

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In vitro electrocardiographic and cardiac ion channel effects of (-)-epigallocatechin-3-gallate, the main catechin of green tea

The Journal of pharmacology and experimental therapeutics, 2010-08, Vol.334 (2), p.619-626

2010

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Design of bivalent ligands using hydrogen bond linkers: synthesis and evaluation of inhibitors for human β-tryptase

Bioorganic & medicinal chemistry letters, 2004-12, Vol.14 (24), p.6053-6056

2004

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L-Type Ca 2+ Channel Responses to Bay K 8644 in Stem Cell-Derived Cardiomyocytes Are Unusually Dependent on Holding Potential and Charge Carrier

Assay and drug development technologies, 2014-08, Vol.12 (6), p.352-360

2014

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Design and synthesis of a novel series of histamine H sub(3) receptor antagonists through a scaffold hopping strategy

Bioorganic & medicinal chemistry, 2015-02, Vol.23 (3), p.429-438

2015

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Ca 2+ Channel Activators Reveal Differential L-Type Ca 2+ Channel Pharmacology between Native and Stem Cell-Derived Cardiomyocytes

The Journal of pharmacology and experimental therapeutics, 2012-05, Vol.341 (2), p.510-517

2012

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Design and synthesis of a novel series of histamine H3 receptor antagonists through a scaffold hopping strategy

Bioorganic & medicinal chemistry, 2015-02, Vol.23 (3), p.429-438

2015

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Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic

Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat

Pentamidine-induced long QT syndrome and block of hERG trafficking

A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs

Discovery of a Small Molecule Activator of the Human Ether-a-go-go-Related Gene (HERG) Cardiac K+ Channel

Interactions of a Series of Fluoroquinolone Antibacterial Drugs with the Human Cardiac K+ Channel HERG

Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches

Predictive models for hERG potassium channel blockers

A β-tryptase inhibitor with a tropanylamide scaffold to improve in vitro stability and to lower hERG channel binding affinity

A Novel Gene, hKCa4, Encodes the Calcium-activated Potassium Channel in Human T Lymphocytes

Mechanisms underlying the QT interval-prolonging effects of sevoflurane and its interactions with other QT-prolonging drugs

High affinity blockade of the HERG cardiac K + channel by the neuroleptic pimozide

Cardiac ion channel effects of tolterodine

Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK and HERG

Molecular determinants of loperamide and N-desmethyl loperamide binding in the hERG cardiac K+ channel

L-type Ca2+ channel responses to bay k 8644 in stem cell-derived cardiomyocytes are unusually dependent on holding potential and charge carrier

Observations on conducting whole‐cell patch clamping of the hERG cardiac K+ channel in pure human serum

Observations on conducting whole-cell patch clamping of the hERG cardiac K super(+) channel in pure human serum

Ca²⁺ channel activators reveal differential L-type Ca²⁺ channel pharmacology between native and stem cell-derived cardiomyocytes

In vitro electrocardiographic and cardiac ion channel effects of (-)-epigallocatechin-3-gallate, the main catechin of green tea

Design of bivalent ligands using hydrogen bond linkers: synthesis and evaluation of inhibitors for human β-tryptase

L-Type Ca 2+ Channel Responses to Bay K 8644 in Stem Cell-Derived Cardiomyocytes Are Unusually Dependent on Holding Potential and Charge Carrier

Design and synthesis of a novel series of histamine H sub(3) receptor antagonists through a scaffold hopping strategy

Ca 2+ Channel Activators Reveal Differential L-Type Ca 2+ Channel Pharmacology between Native and Stem Cell-Derived Cardiomyocytes

Design and synthesis of a novel series of histamine H3 receptor antagonists through a scaffold hopping strategy

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