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Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

Scientific reports, 2017-11, Vol.7 (1), p.14620-11, Article 14620

2017

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Evaluation of HepaRG cells as an in vitro model for human drug metabolism studies

Drug metabolism and disposition, 2008-07, Vol.36 (7), p.1444-1452

2008

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Primary Human Hepatocyte Spheroid Model as a 3D In Vitro Platform for Metabolism Studies

Journal of pharmaceutical sciences, 2021-01, Vol.110 (1), p.422-431

2021

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HepaRG cells as an in vitro model for evaluation of cytochrome P450 induction in humans

Drug metabolism and disposition, 2008-01, Vol.36 (1), p.137-145

2008

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Integrated experimental-computational analysis of a HepaRG liver-islet microphysiological system for human-centric diabetes research

PLoS computational biology, 2022-10, Vol.18 (10), p.e1010587-e1010587

2022

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Critical differences in drug metabolic properties of human hepatic cellular models, including primary human hepatocytes, stem cell derived hepatocytes, and hepatoma cell lines

Biochemical pharmacology, 2018-09, Vol.155, p.124-140

2018

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Human hepatocytes and cytochrome P450‐selective inhibitors predict variability in human drug exposure more accurately than human recombinant P450s

British journal of pharmacology, 2018-06, Vol.175 (11), p.2116-2129

2018

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Managing the Risk of CYP3A Induction in Drug Development: A Strategic Approach

Drug metabolism and disposition, 2017-01, Vol.45 (1), p.35-41

2017

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3D cell aggregates amplify diffusion signals

PloS one, 2024-09, Vol.19 (9), p.e0310109

2024

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The HepaRG cell line: a unique in vitro tool for understanding drug metabolism and toxicology in human

Expert opinion on drug metabolism & toxicology, 2012-07, Vol.8 (7), p.909-920

2012

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Normoglycemia and physiological cortisone level maintain glucose homeostasis in a pancreas-liver microphysiological system

Communications biology, 2024-07, Vol.7 (1), p.877-23, Article 877

2024

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The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids

Scientific reports, 2019-08, Vol.9 (1), p.11585-11585, Article 11585

2019

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Physiologically Based Pharmacokinetic Model of Itraconazole and Two of Its Metabolites to Improve the Predictions and the Mechanistic Understanding of CYP3A4 Drug-Drug Interactions

Drug metabolism and disposition, 2018-10, Vol.46 (10), p.1420-1433

2018

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4β‐Hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half‐life of elimination after induction with rifampicin

British journal of clinical pharmacology, 2009-01, Vol.67 (1), p.38-43

2009

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A comparison of 4β‐hydroxycholesterol : cholesterol and 6β‐hydroxycortisol : cortisol as markers of CYP3A4 induction

British journal of clinical pharmacology, 2013-06, Vol.75 (6), p.1536-1540

2013

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Optimized experimental design for the estimation of enzyme kinetic parameters: an experimental evaluation

Drug metabolism and disposition, 2012-12, Vol.40 (12), p.2273-2279

2012

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Publisher Correction: Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

Scientific reports, 2018-01, Vol.8 (1), p.1672-1, Article 1672

2018

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Development of a primary human hepatocyte spheroid culture model for drug metabolism and disposition studies

Drug metabolism and pharmacokinetics, 2018-01, Vol.33 (1), p.S69-S69

2018

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4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin

British journal of clinical pharmacology, 2009-01, Vol.67 (1), p.38-43

2009

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Induction of Human Cytochrome P450 Enzymes : Predictive in Vitro Models and Rifampicin Induction in Vivo

Kanebratt, Kajsa P

2008

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Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

Evaluation of HepaRG cells as an in vitro model for human drug metabolism studies

Primary Human Hepatocyte Spheroid Model as a 3D In Vitro Platform for Metabolism Studies

HepaRG cells as an in vitro model for evaluation of cytochrome P450 induction in humans

Integrated experimental-computational analysis of a HepaRG liver-islet microphysiological system for human-centric diabetes research

Critical differences in drug metabolic properties of human hepatic cellular models, including primary human hepatocytes, stem cell derived hepatocytes, and hepatoma cell lines

Human hepatocytes and cytochrome P450‐selective inhibitors predict variability in human drug exposure more accurately than human recombinant P450s

Managing the Risk of CYP3A Induction in Drug Development: A Strategic Approach

3D cell aggregates amplify diffusion signals

The HepaRG cell line: a unique in vitro tool for understanding drug metabolism and toxicology in human

Normoglycemia and physiological cortisone level maintain glucose homeostasis in a pancreas-liver microphysiological system

The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids

Physiologically Based Pharmacokinetic Model of Itraconazole and Two of Its Metabolites to Improve the Predictions and the Mechanistic Understanding of CYP3A4 Drug-Drug Interactions

4β‐Hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half‐life of elimination after induction with rifampicin

A comparison of 4β‐hydroxycholesterol : cholesterol and 6β‐hydroxycortisol : cortisol as markers of CYP3A4 induction

Optimized experimental design for the estimation of enzyme kinetic parameters: an experimental evaluation

Publisher Correction: Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

Development of a primary human hepatocyte spheroid culture model for drug metabolism and disposition studies

4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin

Induction of Human Cytochrome P450 Enzymes : Predictive in Vitro Models and Rifampicin Induction in Vivo

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