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The regulatory light chain mediates inactivation of myosin motors during active shortening of cardiac muscle

Nature communications, 2021-09, Vol.12 (1), p.5272-5272, Article 5272

2021

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Myosin light chain phosphorylation enhances contraction of heart muscle via structural changes in both thick and thin filaments

Proceedings of the National Academy of Sciences - PNAS, 2016-05, Vol.113 (21), p.E3039-E3047

2016

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Phosphorylation of myosin regulatory light chain controls myosin head conformation in cardiac muscle

Journal of molecular and cellular cardiology, 2015-08, Vol.85, p.199-206

2015

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Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filament

The Journal of physiology, 2018-01, Vol.596 (1), p.31-46

2018

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Myosin binding protein-C activates thin filaments and inhibits thick filaments in heart muscle cells

Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (52), p.18763-18768

2014

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Discovery of a novel cardiac-specific myosin modulator using artificial intelligence-based virtual screening

Nature communications, 2023-11, Vol.14 (1), p.7692-7692, Article 7692

2023

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Discovery of novel cardiac troponin activators using fluorescence polarization-based high throughput screening assays

Scientific reports, 2023-03, Vol.13 (1), p.5216-5216, Article 5216

2023

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The N-Terminal Lobe of The Myosin Regulatory Light Chain is Part of a Sarcomeric Length Sensor in Cardiac Muscle

Biophysical journal, 2021-02, Vol.120 (3), p.6a-6a

Kampourakis, Thomas

2021

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Cardiac myosin regulatory light chain kinase modulates cardiac contractility by phosphorylating both myosin regulatory light chain and troponin I

The Journal of biological chemistry, 2020-04, Vol.295 (14), p.4398-4410

2020

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Microscale thermophoresis suggests a new model of regulation of cardiac myosin function via interaction with cardiac myosin-binding protein C

The Journal of biological chemistry, 2022-01, Vol.298 (1), p.101485-101485, Article 101485

2022

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Basic science methods for the characterization of variants of uncertain significance in hypertrophic cardiomyopathy

Frontiers in cardiovascular medicine, 2023-08, Vol.10, p.1238515-1238515

2023

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Hypertrophic cardiomyopathy mutation R58Q in the myosin regulatory light chain perturbs thick filament-based regulation in cardiac muscle

Journal of molecular and cellular cardiology, 2018-04, Vol.117, p.72-81

2018

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Site-specific phosphorylation of myosin binding protein-C coordinates thin and thick filament activation in cardiac muscle

Proceedings of the National Academy of Sciences - PNAS, 2019-07, Vol.116 (31), p.15485-15494

2019

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The mechanism of cardiac thin filament inhibition: the precision of W7

Biophysical journal, 2022-02, Vol.121 (3), p.107a-108a

2022

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Fluorescently Labelled Myosin Regulatory Light Chains as Biosensors for Thick Filament Activation in Heart Muscle

Biophysical journal, 2019-02, Vol.116 (3), p.386a-386a

2019

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In situ FRET-based localization of the N terminus of myosin binding protein-C in heart muscle cells

Proceedings of the National Academy of Sciences - PNAS, 2023-03, Vol.120 (12), p.e2222005120-e2222005120

2023

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Stress-dependent activation of myosin in the heart requires thin filament activation and thick filament mechanosensing

Proceedings of the National Academy of Sciences - PNAS, 2021-04, Vol.118 (16), p.1

2021

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Attenuation of sarcomere shortening in isolated porcine cardiomyocytes by a novel myosin S2 stabilizer peptide

Biophysical journal, 2024-02, Vol.123 (3), p.124a-125a

2024

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Phosphorylation-dependent interactions of myosin-binding protein C and troponin coordinate the myofilament response to protein kinase A

The Journal of biological chemistry, 2023-01, Vol.299 (1), p.102767-102767, Article 102767

2023

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Structural and functional effects of myosin-binding protein-C phosphorylation in heart muscle are not mimicked by serine-to-aspartate substitutions

The Journal of biological chemistry, 2018-09, Vol.293 (37), p.14270-14275

2018

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Missense mutations in the central domains of cardiac myosin binding protein-C and their potential contribution to hypertrophic cardiomyopathy

The Journal of biological chemistry, 2024-01, Vol.300 (1), p.105511-105511, Article 105511

2024

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Structural Changes in the Myosin Motors Induced by Stretch and Phosphorylation of the Myosin Regulatory Light Chain in Rat Cardiac Trabeculae

Biophysical journal, 2021-02, Vol.120 (3), p.251a-252a

2021

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Drugging the Sarcomere, a Delicate Balance: Position of N‑Terminal Charge of the Inhibitor W7

ACS chemical biology, 2022-06, Vol.17 (6), p.1495-1504

2022

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Myosin S2 stabilizer peptide decreases recovery rates of contraction

Biophysical journal, 2023-02, Vol.122 (3), p.401a-401a

2023

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The Role of Electrostatics in the Desensitization of Cardiac Muscle Contraction

Biophysical journal, 2020-02, Vol.118 (3), p.421a-421a

2020

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The regulatory light chain mediates inactivation of myosin motors during active shortening of cardiac muscle

Myosin light chain phosphorylation enhances contraction of heart muscle via structural changes in both thick and thin filaments

Phosphorylation of myosin regulatory light chain controls myosin head conformation in cardiac muscle

Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filament

Myosin binding protein-C activates thin filaments and inhibits thick filaments in heart muscle cells

Discovery of a novel cardiac-specific myosin modulator using artificial intelligence-based virtual screening

Discovery of novel cardiac troponin activators using fluorescence polarization-based high throughput screening assays

The N-Terminal Lobe of The Myosin Regulatory Light Chain is Part of a Sarcomeric Length Sensor in Cardiac Muscle

Cardiac myosin regulatory light chain kinase modulates cardiac contractility by phosphorylating both myosin regulatory light chain and troponin I

Microscale thermophoresis suggests a new model of regulation of cardiac myosin function via interaction with cardiac myosin-binding protein C

Basic science methods for the characterization of variants of uncertain significance in hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy mutation R58Q in the myosin regulatory light chain perturbs thick filament-based regulation in cardiac muscle

Site-specific phosphorylation of myosin binding protein-C coordinates thin and thick filament activation in cardiac muscle

The mechanism of cardiac thin filament inhibition: the precision of W7

Fluorescently Labelled Myosin Regulatory Light Chains as Biosensors for Thick Filament Activation in Heart Muscle

In situ FRET-based localization of the N terminus of myosin binding protein-C in heart muscle cells

Stress-dependent activation of myosin in the heart requires thin filament activation and thick filament mechanosensing

Attenuation of sarcomere shortening in isolated porcine cardiomyocytes by a novel myosin S2 stabilizer peptide

Phosphorylation-dependent interactions of myosin-binding protein C and troponin coordinate the myofilament response to protein kinase A

Structural and functional effects of myosin-binding protein-C phosphorylation in heart muscle are not mimicked by serine-to-aspartate substitutions

Missense mutations in the central domains of cardiac myosin binding protein-C and their potential contribution to hypertrophic cardiomyopathy

Structural Changes in the Myosin Motors Induced by Stretch and Phosphorylation of the Myosin Regulatory Light Chain in Rat Cardiac Trabeculae

Drugging the Sarcomere, a Delicate Balance: Position of N‑Terminal Charge of the Inhibitor W7

Myosin S2 stabilizer peptide decreases recovery rates of contraction

The Role of Electrostatics in the Desensitization of Cardiac Muscle Contraction

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