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Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

Cancer cell, 2015-07, Vol.28 (1), p.42-56

2015

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Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area

Proceedings of the National Academy of Sciences - PNAS, 2014-04, Vol.111 (16), p.E1648-E1655

2014

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Insular hypocretin transmission regulates nicotine reward

Proceedings of the National Academy of Sciences - PNAS, 2008-12, Vol.105 (49), p.19480-19485

2008

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Suppression of atherosclerosis by synthetic REV-ERB agonist

Biochemical and biophysical research communications, 2015-05, Vol.460 (3), p.566-571

2015

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Genetic and pharmacological inhibition of the nuclear receptor RORα regulates TH17 driven inflammatory disorders

Nature communications, 2021-01, Vol.12 (1), p.1-18, Article 76

2021

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Structural mechanism for signal transduction in RXR nuclear receptor heterodimers

Nature communications, 2015-08, Vol.6 (1), p.8013-8013, Article 8013

2015

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A structural mechanism for directing corepressor-selective inverse agonism of PPARγ

Nature communications, 2018-11, Vol.9 (1), p.4687-14, Article 4687

2018

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Identification of SR8278, a Synthetic Antagonist of the Nuclear Heme Receptor REV-ERB

ACS chemical biology, 2011-02, Vol.6 (2), p.131-134

2011

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Ligand and Receptor Dynamics Contribute to the Mechanism of Graded PPARγ Agonism

Structure (London), 2012-01, Vol.20 (1), p.139-150

2012

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Defining a conformational ensemble that directs activation of PPARγ

Nature communications, 2018-05, Vol.9 (1), p.1794-16, Article 1794

2018

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Nuclear receptor RORα regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation

Proceedings of the National Academy of Sciences - PNAS, 2015-08, Vol.112 (33), p.10401-10406

2015

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Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ

Nature communications, 2019-12, Vol.10 (1), p.5825-14, Article 5825

2019

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Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation

PLoS biology, 2018-06, Vol.16 (6), p.e2004663-e2004663

2018

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Bioactivation of the Epidermal Growth Factor Receptor Inhibitor Gefitinib: Implications for Pulmonary and Hepatic Toxicities

Chemical research in toxicology, 2009-10, Vol.22 (10), p.1736-1742

2009

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SR9883 is a novel small-molecule enhancer of α4β2 nicotinic acetylcholine receptor signaling that decreases intravenous nicotine self-administration in rats

Frontiers in molecular neuroscience, 2024-09, Vol.17, p.1459098

2024

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REV-ERBα regulates age-related and oxidative stress-induced degeneration in retinal pigment epithelium via NRF2

Redox biology, 2022-05, Vol.51, p.102261-102261, Article 102261

2022

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Regulation of Adipogenesis by Natural and Synthetic REV-ERB Ligands

Endocrinology (Philadelphia), 2010-07, Vol.151 (7), p.3015-3025

2010

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Pharmacological Targeting the REV-ERBs in Sleep/Wake Regulation

PloS one, 2016-09, Vol.11 (9), p.e0162452-e0162452

2016

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HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists

eLife, 2019-06, Vol.8

2019

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Site‐Selective γ‐C(sp3)−H and γ‐C(sp2)−H Arylation of Free Amino Esters Promoted by a Catalytic Transient Directing Group

Chemistry : a European journal, 2018-07, Vol.24 (38), p.9535-9541

2018

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TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway

Molecular metabolism (Germany), 2016-10, Vol.5 (10), p.903-917

2016

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LXR-mediated inhibition of CD4+ T helper cells

PloS one, 2012-09, Vol.7 (9), p.e46615-e46615

2012

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PPARγ in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix

iScience, 2018-07, Vol.5, p.69-79

2018

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Pharmacological modulation and genetic deletion of REV-ERBα and REV-ERBβ regulates dendritic cell development

Biochemical and biophysical research communications, 2020-07, Vol.527 (4), p.1000-1007

2020

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Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

Nature (London), 2011-04, Vol.472 (7344), p.491-494

2011

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Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area

Insular hypocretin transmission regulates nicotine reward

Suppression of atherosclerosis by synthetic REV-ERB agonist

Genetic and pharmacological inhibition of the nuclear receptor RORα regulates TH17 driven inflammatory disorders

Structural mechanism for signal transduction in RXR nuclear receptor heterodimers

A structural mechanism for directing corepressor-selective inverse agonism of PPARγ

Identification of SR8278, a Synthetic Antagonist of the Nuclear Heme Receptor REV-ERB

Ligand and Receptor Dynamics Contribute to the Mechanism of Graded PPARγ Agonism

Defining a conformational ensemble that directs activation of PPARγ

Nuclear receptor RORα regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation

Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ

Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation

Bioactivation of the Epidermal Growth Factor Receptor Inhibitor Gefitinib: Implications for Pulmonary and Hepatic Toxicities

SR9883 is a novel small-molecule enhancer of α4β2 nicotinic acetylcholine receptor signaling that decreases intravenous nicotine self-administration in rats

REV-ERBα regulates age-related and oxidative stress-induced degeneration in retinal pigment epithelium via NRF2

Regulation of Adipogenesis by Natural and Synthetic REV-ERB Ligands

Pharmacological Targeting the REV-ERBs in Sleep/Wake Regulation

HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists

Site‐Selective γ‐C(sp3)−H and γ‐C(sp2)−H Arylation of Free Amino Esters Promoted by a Catalytic Transient Directing Group

TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway

LXR-mediated inhibition of CD4+ T helper cells

PPARγ in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix

Pharmacological modulation and genetic deletion of REV-ERBα and REV-ERBβ regulates dendritic cell development

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

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