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MyD88 and beyond: a perspective on MyD88-targeted therapeutic approach for modulation of host immunity

Immunologic research, 2021-04, Vol.69 (2), p.117-128

Saikh, Kamal U.

2021

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Activation of MyD88 signaling upon staphylococcal enterotoxin binding to MHC class II molecules

PloS one, 2011-01, Vol.6 (1), p.e15985

2011

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Protective Immunization against Inhalational Anthrax: A Comparison of Minimally Invasive Delivery Platforms

The Journal of infectious diseases, 2005-01, Vol.191 (2), p.278-288

2005

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Therapeutic inhibition of pro-inflammatory signaling and toxicity to staphylococcal enterotoxin B by a synthetic dimeric BB-loop mimetic of MyD88

PloS one, 2012-07, Vol.7 (7), p.e40773

2012

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Staphylococcal enterotoxin A induction of pro-inflammatory cytokines and lethality in mice is primarily dependent on MyD88

Immunology, 2010-08, Vol.130 (4), p.516-526

2010

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Cells Stimulated with More Than One Toll-Like Receptor-Ligand in the Presence of a MyD88 Inhibitor Augmented Interferon- β via MyD88-Independent Signaling Pathway

Viral immunology, 2021-11, Vol.34 (9), p.646

2021

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A small molecule inhibitor of MyD88 exhibits broad spectrum antiviral activity by up regulation of type I interferon

Antiviral research, 2020-09, Vol.181, p.104854-104854, Article 104854

2020

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An increase in p62/NBR1 levels in melioidosis patients of Sri Lanka exhibit a characteristic of potential host biomarker

Journal of medical microbiology, 2020-10, Vol.69 (10), p.1240-1248

2020

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Innate immune response to Burkholderia mallei

Current opinion in infectious diseases, 2017-06, Vol.30 (3), p.297-302

2017

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Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen

Scientific reports, 2015-09, Vol.5 (1), p.14246, Article 14246

2015

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Small Molecule Analogues of the parasitic worm product ES-62 interact with the TIR domain of MyD88 to inhibit pro-inflammatory signalling

Scientific reports, 2018-02, Vol.8 (1), p.2123-11, Article 2123

2018

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Toll-Like Receptor and Cytokine Expression Patterns of CD56+ T Cells Are Similar to Natural Killer Cells in Response to Infection with Venezuelan Equine Encephalitis Virus Replicons

The Journal of infectious diseases, 2003-11, Vol.188 (10), p.1562-1570

2003

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Interleukin-15 Increases Vaccine Efficacy through a Mechanism Linked to Dendritic Cell Maturation and Enhanced Antibody Titers

Clinical and Vaccine Immunology, 2008-01, Vol.15 (1), p.131-137

2008

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Author Correction: Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen

Scientific reports, 2018-11, Vol.8 (1), p.17074-2, Article 17074

2018

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Rational design of peptide derivatives for inhibition of MyD88‐mediated toll‐like receptor signaling in human peripheral blood mononuclear cells and epithelial cells exposed to Francisella tularensis

Chemical biology & drug design, 2017-12, Vol.90 (6), p.1190-1205

2017

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Human Cytolytic T Cell Recognition of Yersinia pestis Virulence Proteins That Target Innate Immune Responses

The Journal of infectious diseases, 2006-12, Vol.194 (12), p.1753-1760

2006

Volltextzugriff (PDF)

A Small Molecule That Mimics the BB-loop in the Toll Interleukin-1 (IL-1) Receptor Domain of MyD88 Attenuates Staphylococcal Enterotoxin B-induced Pro-inflammatory Cytokine Production and Toxicity in Mice

The Journal of biological chemistry, 2011-09, Vol.286 (36), p.31385-31396

2011

Volltextzugriff (PDF)

An increase in intracellular p62/NBR1 and persistence of Burkholderia mallei and B. pseudomallei in infected mice linked to autophagy deficiency

Immunity, Inflammation and Disease, 2019-03, Vol.7 (1), p.7-21

2019

Volltextzugriff (PDF)

Characterization of cellular immune response and innate immune signaling in human and nonhuman primate primary mononuclear cells exposed to Burkholderia mallei

Microbial pathogenesis, 2015-01, Vol.78, p.20-28

2015

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Structure-Based Design and Synthesis of a Small Molecule that Exhibits Anti-inflammatory Activity by Inhibition of MyD88-mediated Signaling to Bacterial Toxin Exposure

Chemical biology & drug design, 2015-08, Vol.86 (2), p.200-209

2015

Volltextzugriff (PDF)

MyD88-dependent pro-inflammatory cytokine response contributes to lethal toxicity of staphylococcal enterotoxin B in mice

Innate immunity (London, England), 2011-10, Vol.17 (5), p.451-462

2011

Volltextzugriff (PDF)

Human Monocytes Infected with Yersinia pestis Express Cell Surface TLR9 and Differentiate into Dendritic Cells

The Journal of immunology (1950), 2004-12, Vol.173 (12), p.7426-7434

2004

Volltextzugriff (PDF)

CD56+-T-Cell Responses to Bacterial Superantigens and Immune Recognition of Attenuated Vaccines

Clinical and Diagnostic Laboratory Immunology, 2003-11, Vol.10 (6), p.1065-1073

2003

Volltextzugriff (PDF)

Targeting Myeloid Differentiation Primary Response Protein 88 (MyD88) and Galectin-3 to Develop Broad-Spectrum Host-Mediated Therapeutics against SARS-CoV-2

International journal of molecular sciences, 2024-08, Vol.25 (15), p.8421

2024

Volltextzugriff (PDF)

Comparison of the protective efficacy of DNA and baculovirus-derived protein vaccines for EBOLA virus in guinea pigs

Virus research, 2003-04, Vol.92 (2), p.187-193

2003

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MyD88 and beyond: a perspective on MyD88-targeted therapeutic approach for modulation of host immunity

Activation of MyD88 signaling upon staphylococcal enterotoxin binding to MHC class II molecules

Protective Immunization against Inhalational Anthrax: A Comparison of Minimally Invasive Delivery Platforms

Therapeutic inhibition of pro-inflammatory signaling and toxicity to staphylococcal enterotoxin B by a synthetic dimeric BB-loop mimetic of MyD88

Staphylococcal enterotoxin A induction of pro-inflammatory cytokines and lethality in mice is primarily dependent on MyD88

Cells Stimulated with More Than One Toll-Like Receptor-Ligand in the Presence of a MyD88 Inhibitor Augmented Interferon- β via MyD88-Independent Signaling Pathway

A small molecule inhibitor of MyD88 exhibits broad spectrum antiviral activity by up regulation of type I interferon

An increase in p62/NBR1 levels in melioidosis patients of Sri Lanka exhibit a characteristic of potential host biomarker

Innate immune response to Burkholderia mallei

Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen

Small Molecule Analogues of the parasitic worm product ES-62 interact with the TIR domain of MyD88 to inhibit pro-inflammatory signalling

Toll-Like Receptor and Cytokine Expression Patterns of CD56+ T Cells Are Similar to Natural Killer Cells in Response to Infection with Venezuelan Equine Encephalitis Virus Replicons

Interleukin-15 Increases Vaccine Efficacy through a Mechanism Linked to Dendritic Cell Maturation and Enhanced Antibody Titers

Author Correction: Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen

Rational design of peptide derivatives for inhibition of MyD88‐mediated toll‐like receptor signaling in human peripheral blood mononuclear cells and epithelial cells exposed to Francisella tularensis

Human Cytolytic T Cell Recognition of Yersinia pestis Virulence Proteins That Target Innate Immune Responses

A Small Molecule That Mimics the BB-loop in the Toll Interleukin-1 (IL-1) Receptor Domain of MyD88 Attenuates Staphylococcal Enterotoxin B-induced Pro-inflammatory Cytokine Production and Toxicity in Mice

An increase in intracellular p62/NBR1 and persistence of Burkholderia mallei and B. pseudomallei in infected mice linked to autophagy deficiency

Characterization of cellular immune response and innate immune signaling in human and nonhuman primate primary mononuclear cells exposed to Burkholderia mallei

Structure-Based Design and Synthesis of a Small Molecule that Exhibits Anti-inflammatory Activity by Inhibition of MyD88-mediated Signaling to Bacterial Toxin Exposure

MyD88-dependent pro-inflammatory cytokine response contributes to lethal toxicity of staphylococcal enterotoxin B in mice

Human Monocytes Infected with Yersinia pestis Express Cell Surface TLR9 and Differentiate into Dendritic Cells

CD56+-T-Cell Responses to Bacterial Superantigens and Immune Recognition of Attenuated Vaccines

Targeting Myeloid Differentiation Primary Response Protein 88 (MyD88) and Galectin-3 to Develop Broad-Spectrum Host-Mediated Therapeutics against SARS-CoV-2

Comparison of the protective efficacy of DNA and baculovirus-derived protein vaccines for EBOLA virus in guinea pigs

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