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In vitro P-glycoprotein efflux ratio can predict the in vivo brain penetration regardless of biopharmaceutics drug disposition classification system class

Drug metabolism and disposition, 2013-12, Vol.41 (12), p.2012-2017

2013

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Industry Perspective on Contemporary Protein-Binding Methodologies: Considerations for Regulatory Drug-Drug Interaction and Related Guidelines on Highly Bound Drugs

Journal of pharmaceutical sciences, 2017-12, Vol.106 (12), p.3442-3452

2017

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Kinetic considerations for the quantitative assessment of efflux activity and inhibition : Implications for understanding and predicting the effects of efflux inhibition

Pharmaceutical research, 2007-02, Vol.24 (2), p.265-276

2007

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Use of plasma and brain unbound fractions to assess the extent of brain distribution of 34 drugs: comparison of unbound concentration ratios to in vivo p-glycoprotein efflux ratios

Drug metabolism and disposition, 2007-04, Vol.35 (4), p.660-666

2007

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Influence of nonspecific brain and plasma binding on CNS exposure: implications for rational drug discovery

Biopharmaceutics & drug disposition, 2002-11, Vol.23 (8), p.327-338

2002

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In Vivo Activation of Human Pregnane X Receptor Tightens the Blood-Brain Barrier to Methadone through P-Glycoprotein Up-Regulation

Molecular pharmacology, 2006-10, Vol.70 (4), p.1212-1219

2006

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Pharmacokinetics and pharmacodynamics of seven opioids in P-glycoprotein-competent mice: assessment of unbound brain EC50,u and correlation of in vitro, preclinical, and clinical data

The Journal of pharmacology and experimental therapeutics, 2007-10, Vol.323 (1), p.346

2007

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Relationship between drug/metabolite exposure and impairment of excretory transport function

Drug metabolism and disposition, 2009-02, Vol.37 (2), p.386-390

2009

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Assessment of Blood-Brain Barrier Permeability Using the In Situ Mouse Brain Perfusion Technique

Pharmaceutical research, 2009-07, Vol.26 (7), p.1657-1664

2009

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Global Analysis of Models for Predicting Human Absorption: QSAR, In Vitro, and Preclinical Models

Journal of medicinal chemistry, 2021-07, Vol.64 (13), p.9389-9403

2021

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Microdialysis evaluation of atomoxetine brain penetration and central nervous system pharmacokinetics in rats

Drug metabolism and disposition, 2009-01, Vol.37 (1), p.137-142

2009

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How predictive are isolated perfused liver data of in vivo hepatic clearance? A meta-analysis of isolated perfused rat liver data

Xenobiotica, 2024-09, p.1-12

2024

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A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins

CPT: pharmacometrics and systems pharmacology, 2019-11, Vol.8 (11), p.773-776

2019

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The Important Role of Bcrp (Abcg2) in the Biliary Excretion of Sulfate and Glucuronide Metabolites of Acetaminophen, 4-Methylumbelliferone, and Harmol in Mice

Molecular pharmacology, 2006-12, Vol.70 (6), p.2127-2133

2006

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Fexofenadine brain exposure and the influence of blood-brain barrier P-glycoprotein after fexofenadine and terfenadine administration

Drug metabolism and disposition, 2009-03, Vol.37 (3), p.529-535

2009

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Soy Protein Containing Diet Attenuates Murine Drug Exposure and Activity via Hepatic and Intestinal Cytochrome P450 Induction

Drug metabolism and disposition, 2023-08, Vol.51 (8), p.1005-1015

2023

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Mathematical and Experimental Validation of Flux Dialysis Method: An Improved Approach to Measure Unbound Fraction for Compounds with High Protein Binding and Other Challenging Properties

Drug metabolism and disposition, 2018-04, Vol.46 (4), p.458-469

2018

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Pharmacokinetics and pharmacodynamics of alfentanil in P-glycoprotein-competent and P-glycoprotein-deficient mice: P-glycoprotein efflux alters alfentanil brain disposition and antinociception

Drug metabolism and disposition, 2007-03, Vol.35 (3), p.455-459

2007

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Multiple mechanisms are involved in the biliary excretion of acetaminophen sulfate in the rat: role of Mrp2 and Bcrp1

Drug metabolism and disposition, 2005-08, Vol.33 (8), p.1158-1165

2005

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Improving in vitro clearance assay performance and prediction accuracy with advanced human hepatocyte models for highly stable RO5 and BRO5 compounds

Drug metabolism and pharmacokinetics, 2024-04, Vol.55, p.100820, Article 100820

2024

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Determination of IL-23 Pharmacokinetics by Highly Sensitive Accelerator Mass Spectrometry and Subsequent Modeling to Project IL-23 Suppression in Psoriasis Patients Treated with Anti-IL-23 Antibodies

The AAPS journal, 2019-09, Vol.21 (5), p.82-82, Article 82

2019

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Hepatobiliary disposition of a drug/metabolite pair: Comprehensive pharmacokinetic modeling in sandwich-cultured rat hepatocytes

The Journal of pharmacology and experimental therapeutics, 2006-08, Vol.318 (2), p.881-889

2006

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Unbound Brain-to-Plasma Partition Coefficient, K.sub.p,uu,brain-a Game Changing Parameter for CNS Drug Discovery and Development

Pharmaceutical research, 2022-07, Vol.39 (7), p.1321

2022

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Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development

Pharmaceutical research, 2022-07, Vol.39 (7), p.1321-1341

2022

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Use of loperamide as a phenotypic probe of mdr1a status in CF-1 mice

Pharmaceutical research, 2004-10, Vol.21 (10), p.1867-1870

2004

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In vitro P-glycoprotein efflux ratio can predict the in vivo brain penetration regardless of biopharmaceutics drug disposition classification system class

Industry Perspective on Contemporary Protein-Binding Methodologies: Considerations for Regulatory Drug-Drug Interaction and Related Guidelines on Highly Bound Drugs

Kinetic considerations for the quantitative assessment of efflux activity and inhibition : Implications for understanding and predicting the effects of efflux inhibition

Use of plasma and brain unbound fractions to assess the extent of brain distribution of 34 drugs: comparison of unbound concentration ratios to in vivo p-glycoprotein efflux ratios

Influence of nonspecific brain and plasma binding on CNS exposure: implications for rational drug discovery

In Vivo Activation of Human Pregnane X Receptor Tightens the Blood-Brain Barrier to Methadone through P-Glycoprotein Up-Regulation

Pharmacokinetics and pharmacodynamics of seven opioids in P-glycoprotein-competent mice: assessment of unbound brain EC50,u and correlation of in vitro, preclinical, and clinical data

Relationship between drug/metabolite exposure and impairment of excretory transport function

Assessment of Blood-Brain Barrier Permeability Using the In Situ Mouse Brain Perfusion Technique

Global Analysis of Models for Predicting Human Absorption: QSAR, In Vitro, and Preclinical Models

Microdialysis evaluation of atomoxetine brain penetration and central nervous system pharmacokinetics in rats

How predictive are isolated perfused liver data of in vivo hepatic clearance? A meta-analysis of isolated perfused rat liver data

A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins

The Important Role of Bcrp (Abcg2) in the Biliary Excretion of Sulfate and Glucuronide Metabolites of Acetaminophen, 4-Methylumbelliferone, and Harmol in Mice

Fexofenadine brain exposure and the influence of blood-brain barrier P-glycoprotein after fexofenadine and terfenadine administration

Soy Protein Containing Diet Attenuates Murine Drug Exposure and Activity via Hepatic and Intestinal Cytochrome P450 Induction

Mathematical and Experimental Validation of Flux Dialysis Method: An Improved Approach to Measure Unbound Fraction for Compounds with High Protein Binding and Other Challenging Properties

Pharmacokinetics and pharmacodynamics of alfentanil in P-glycoprotein-competent and P-glycoprotein-deficient mice: P-glycoprotein efflux alters alfentanil brain disposition and antinociception

Multiple mechanisms are involved in the biliary excretion of acetaminophen sulfate in the rat: role of Mrp2 and Bcrp1

Improving in vitro clearance assay performance and prediction accuracy with advanced human hepatocyte models for highly stable RO5 and BRO5 compounds

Determination of IL-23 Pharmacokinetics by Highly Sensitive Accelerator Mass Spectrometry and Subsequent Modeling to Project IL-23 Suppression in Psoriasis Patients Treated with Anti-IL-23 Antibodies

Hepatobiliary disposition of a drug/metabolite pair: Comprehensive pharmacokinetic modeling in sandwich-cultured rat hepatocytes

Unbound Brain-to-Plasma Partition Coefficient, K.sub.p,uu,brain-a Game Changing Parameter for CNS Drug Discovery and Development

Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development

Use of loperamide as a phenotypic probe of mdr1a status in CF-1 mice

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