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Genomic and molecular characterization of esophageal squamous cell carcinoma

Nature genetics, 2014-05, Vol.46 (5), p.467-473

2014

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Conserved interactions required for inhibition of the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Scientific reports, 2020-11, Vol.10 (1), p.20808, Article 20808

2020

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A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action

Nature communications, 2017-06, Vol.8 (1), p.15772-15772, Article 15772

2017

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Consensus Induced Fit Docking (cIFD): methodology, validation, and application to the discovery of novel Crm1 inhibitors

Journal of computer-aided molecular design, 2012-11, Vol.26 (11), p.1217-1228

2012

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New Model of Cystic Fibrosis Transmembrane Conductance Regulator Proposes Active Channel-like Conformation

Journal of chemical information and modeling, 2012-07, Vol.52 (7), p.1842-1853

2012

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Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening

Journal of computer-aided molecular design, 2010-12, Vol.24 (12), p.971-991

2010

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G Protein-Coupled Receptors: In silico Drug Discovery in 3D

Proceedings of the National Academy of Sciences - PNAS, 2004-08, Vol.101 (31), p.11304-11309

2004

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PREDICT modeling and in-silico screening for G-protein coupled receptors

Proteins, structure, function, and bioinformatics, 2004-10, Vol.57 (1), p.51-86

2004

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Structure-Based Virtual Screening Approach for Discovery of Covalently Bound Ligands

Journal of chemical information and modeling, 2014-07, Vol.54 (7), p.1941-1950

2014

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PTX80, a novel compound targeting the autophagy receptor p62/SQSTM1 for treatment of cancer

Chemical biology & drug design, 2022-11, Vol.100 (5), p.623-638

2022

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Study of MDM2 Binding to p53-Analogues: Affinity, Helicity, and Applicability to Drug Design

Journal of Chemical Information and Modeling, 2009-04, Vol.49 (4), p.865-876

2009

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Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compounds

BMC cancer, 2015-11, Vol.15 (909), p.910, Article 910

2015

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5-OMe-UDP is a potent and selective P2Y(6)-receptor agonist

Journal of medicinal chemistry, 2010-02, Vol.53 (4), p.1673-1685

2010

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Conformational Changes Relevant to Channel Activity and Folding within the first Nucleotide Binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator

The Journal of biological chemistry, 2012-08, Vol.287 (34), p.28480-28494

2012

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5-OMe-UDP is a Potent and Selective P2Y6-Receptor Agonist

Journal of medicinal chemistry, 2010-02, Vol.53 (4), p.1673-1685

2010

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Selinexor-Induced Thrombocytopenia Results from the Inhibition of Megakaryocyte Progenitor Cells in the Early Stage of Megakaryopoiesis

Blood, 2014-12, Vol.124 (21), p.1458-1458

2014

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Abstract 748: Novel selective orally bioavailable small molecule PAK4 allosteric modulators display antitumor activity and induce apoptosis in vitro and in vivo

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.748-748

2014

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Abstract 1771: Novel small molecule pak4 allosteric modulators with activity against pancreatic cancer

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.1771-1771

2014

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Abstract A24: Novel small molecule PAK4 allosteric modulators show potency against oncogenic K-Ras driven pancreatic cancer

Molecular cancer research, 2014-12, Vol.12 (12_Supplement), p.A24-A24

2014

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Novel PAK4 inhibitors for pancreatic cancer therapy

Journal of clinical oncology, 2014-01, Vol.32 (3_suppl), p.233-233

2014

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In Vitro and in Vivo Quantification of Exportin-1 (XPO1) Occupancy By the Oral Selective Inhibitor of Nuclear Export (SINE) Selinexor in Multiple Myeloma, Acute Myeloid Leukemia, and Healthy PBMCs

Blood, 2014-12, Vol.124 (21), p.5196-5196

2014

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Abstract B198: Selinexor (KPT-330), a novel Selective Inhibitor of Nuclear Export (SINE) shows marked NF-kB inhibition and significant anticancer activity against Non-Small Cell Lung Cancer (NSCLC)

Molecular cancer therapeutics, 2013-11, Vol.12 (11_Supplement), p.B198-B198

2013

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Abstract A188: SINE resistant fibrosarcoma cells reveal changes in profile of gene expression, but continue to be sensitive to combination treatment by proteasome inhibition

Molecular cancer therapeutics, 2013-11, Vol.12 (11_Supplement), p.A188-A188

2013

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Abstract 875: Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitors of Nuclear Export (SINE)

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.875-875

2013

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5-OMe-UDP is a Potent and Selective P2Y 6 -Receptor Agonist

Journal of medicinal chemistry, 2010-02, Vol.53 (4), p.1673-1685

2010

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Genomic and molecular characterization of esophageal squamous cell carcinoma

Conserved interactions required for inhibition of the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action

Consensus Induced Fit Docking (cIFD): methodology, validation, and application to the discovery of novel Crm1 inhibitors

New Model of Cystic Fibrosis Transmembrane Conductance Regulator Proposes Active Channel-like Conformation

Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening

G Protein-Coupled Receptors: In silico Drug Discovery in 3D

PREDICT modeling and in-silico screening for G-protein coupled receptors

Structure-Based Virtual Screening Approach for Discovery of Covalently Bound Ligands

PTX80, a novel compound targeting the autophagy receptor p62/SQSTM1 for treatment of cancer

Study of MDM2 Binding to p53-Analogues: Affinity, Helicity, and Applicability to Drug Design

Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compounds

5-OMe-UDP is a potent and selective P2Y(6)-receptor agonist

Conformational Changes Relevant to Channel Activity and Folding within the first Nucleotide Binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator

5-OMe-UDP is a Potent and Selective P2Y6-Receptor Agonist

Selinexor-Induced Thrombocytopenia Results from the Inhibition of Megakaryocyte Progenitor Cells in the Early Stage of Megakaryopoiesis

Abstract 748: Novel selective orally bioavailable small molecule PAK4 allosteric modulators display antitumor activity and induce apoptosis in vitro and in vivo

Abstract 1771: Novel small molecule pak4 allosteric modulators with activity against pancreatic cancer

Abstract A24: Novel small molecule PAK4 allosteric modulators show potency against oncogenic K-Ras driven pancreatic cancer

Novel PAK4 inhibitors for pancreatic cancer therapy

In Vitro and in Vivo Quantification of Exportin-1 (XPO1) Occupancy By the Oral Selective Inhibitor of Nuclear Export (SINE) Selinexor in Multiple Myeloma, Acute Myeloid Leukemia, and Healthy PBMCs

Abstract B198: Selinexor (KPT-330), a novel Selective Inhibitor of Nuclear Export (SINE) shows marked NF-kB inhibition and significant anticancer activity against Non-Small Cell Lung Cancer (NSCLC)

Abstract A188: SINE resistant fibrosarcoma cells reveal changes in profile of gene expression, but continue to be sensitive to combination treatment by proteasome inhibition

Abstract 875: Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitors of Nuclear Export (SINE)

5-OMe-UDP is a Potent and Selective P2Y 6 -Receptor Agonist

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