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A comprehensive listing of bioactivation pathways of organic functional groups

Current drug metabolism, 2005-06, Vol.6 (3), p.161-225

2005

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Interactions of Nitrogen-Containing Xenobiotics with Monoamine Oxidase (MAO) Isozymes A and B: SAR Studies on MAO Substrates and Inhibitors

Chemical research in toxicology, 2001-09, Vol.14 (9), p.1139-1162

2001

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Transporter‐Mediated Hepatic Uptake Plays an Important Role in the Pharmacokinetics and Drug–Drug Interactions of Montelukast

Clinical pharmacology and therapeutics, 2017-03, Vol.101 (3), p.406-415

2017

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A Semiquantitative Method for the Determination of Reactive Metabolite Conjugate Levels in Vitro Utilizing Liquid Chromatography−Tandem Mass Spectrometry and Novel Quaternary Ammonium Glutathione Analogues

Chemical research in toxicology, 2006-03, Vol.19 (3), p.480-490

2006

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Predicting Toxicities of Reactive Metabolite-Positive Drug Candidates

Annual review of pharmacology and toxicology, 2015-01, Vol.55 (1), p.35-54

2015

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Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4

Chemico-biological interactions, 2005-06, Vol.155 (1), p.10-20

2005

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Structural Alerts, Reactive Metabolites, and Protein Covalent Binding: How Reliable Are These Attributes as Predictors of Drug Toxicity?

Chemistry & biodiversity, 2009-11, Vol.6 (11), p.2115-2137

2009

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Can In Vitro Metabolism-Dependent Covalent Binding Data in Liver Microsomes Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis of 18 Drugs with Consideration of Intrinsic Clearance and Daily Dose

Chemical research in toxicology, 2008-09, Vol.21 (9), p.1814-1822

2008

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Reactive Drug Metabolites

1, 2012

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Biotransformation Reactions of Five-Membered Aromatic Heterocyclic Rings

Chemical research in toxicology, 2002-03, Vol.15 (3), p.269-299

2002

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A Novel Mechanism of Cyclooxygenase-2 Inhibition Involving Interactions with Ser-530 and Tyr-385

The Journal of biological chemistry, 2003-11, Vol.278 (46), p.45763-45769

2003

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Minimising the potential for metabolic activation in drug discovery

Expert opinion on drug metabolism & toxicology, 2005-06, Vol.1 (1), p.91-142

2005

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Ester and Amide Derivatives of the Nonsteroidal Antiinflammatory Drug, Indomethacin, as Selective Cyclooxygenase-2 Inhibitors

Journal of medicinal chemistry, 2000-07, Vol.43 (15), p.2860-2870

2000

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Pharmacokinetics and metabolism of a cysteinyl leukotriene-1 receptor antagonist from the heterocyclic chromanol series in rats: in vitro-in vivo correlation, gender-related differences, isoform identification, and comparison with metabolism in human hepatic tissue

Drug metabolism and disposition, 2001-11, Vol.29 (11), p.1403

2001

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Application of a Linear Ion Trap/Orbitrap Mass Spectrometer in Metabolite Characterization Studies: Examination of the Human Liver Microsomal Metabolism of the Non-Tricyclic Anti-Depressant Nefazodone Using Data-Dependent Accurate Mass Measurements

Journal of the American Society for Mass Spectrometry, 2006-03, Vol.17 (3), p.363-375

2006

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Cyclooxygenase 2 inhibitors: discovery, selectivity and the future

Trends in Pharmacological Sciences, 1999-11, Vol.20 (11), p.465-469

1999

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Inhibition of Hepatobiliary Transport as a Predictive Method for Clinical Hepatotoxicity of Nefazodone

Toxicological sciences, 2006-04, Vol.90 (2), p.451-459

2006

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Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition

The Journal of biological chemistry, 1999-08, Vol.274 (33), p.22903

1999

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Biochemically Based Design of Cyclooxygenase-2 (COX-2) Inhibitors: Facile Conversion of Nonsteroidal Antiinflammatory Drugs to Potent and Highly Selective COX-2 Inhibitors

Proceedings of the National Academy of Sciences - PNAS, 2000-01, Vol.97 (2), p.925-930

2000

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Indolyl esters and amides related to indomethacin are selective COX-2 inhibitors

Bioorganic & medicinal chemistry, 2005-12, Vol.13 (24), p.6810-6822

2005

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Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4

Drug metabolism and disposition, 2005-02, Vol.33 (2), p.243-253

2005

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Aspirin-like Molecules that Covalently Inactivate Cyclooxygenase-2

Science (American Association for the Advancement of Science), 1998-05, Vol.280 (5367), p.1268-1270

1998

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IN VITRO METABOLISM STUDIES ON THE ISOXAZOLE RING SCISSION IN THE ANTI-INFLAMMATORY AGENT LEFLUNOMIDE TO ITS ACTIVE α-CYANOENOL METABOLITE A771726: MECHANISTIC SIMILARITIES WITH THE CYTOCHROME P450-CATALYZED DEHYDRATION OF ALDOXIMES

Drug metabolism and disposition, 2003-10, Vol.31 (10), p.1240-1250

2003

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Discovery and design of selective cyclooxygenase-2 inhibitors as non-ulcerogenic, anti-inflammatory drugs with potential utility as anti-cancer agents

Current drug targets, 2001-03, Vol.2 (1), p.79-106

2001

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Identification of an N-methyl-4-phenylpyridinium-like metabolite of the antidiarrheal agent loperamide in human liver microsomes: underlying reason(s) for the lack of neurotoxicity despite the bioactivation event

Drug metabolism and disposition, 2004-09, Vol.32 (9), p.943

2004

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A comprehensive listing of bioactivation pathways of organic functional groups

Interactions of Nitrogen-Containing Xenobiotics with Monoamine Oxidase (MAO) Isozymes A and B: SAR Studies on MAO Substrates and Inhibitors

Transporter‐Mediated Hepatic Uptake Plays an Important Role in the Pharmacokinetics and Drug–Drug Interactions of Montelukast

A Semiquantitative Method for the Determination of Reactive Metabolite Conjugate Levels in Vitro Utilizing Liquid Chromatography−Tandem Mass Spectrometry and Novel Quaternary Ammonium Glutathione Analogues

Predicting Toxicities of Reactive Metabolite-Positive Drug Candidates

Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4

Structural Alerts, Reactive Metabolites, and Protein Covalent Binding: How Reliable Are These Attributes as Predictors of Drug Toxicity?

Can In Vitro Metabolism-Dependent Covalent Binding Data in Liver Microsomes Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis of 18 Drugs with Consideration of Intrinsic Clearance and Daily Dose

Reactive Drug Metabolites

Biotransformation Reactions of Five-Membered Aromatic Heterocyclic Rings

A Novel Mechanism of Cyclooxygenase-2 Inhibition Involving Interactions with Ser-530 and Tyr-385

Minimising the potential for metabolic activation in drug discovery

Ester and Amide Derivatives of the Nonsteroidal Antiinflammatory Drug, Indomethacin, as Selective Cyclooxygenase-2 Inhibitors

Pharmacokinetics and metabolism of a cysteinyl leukotriene-1 receptor antagonist from the heterocyclic chromanol series in rats: in vitro-in vivo correlation, gender-related differences, isoform identification, and comparison with metabolism in human hepatic tissue

Application of a Linear Ion Trap/Orbitrap Mass Spectrometer in Metabolite Characterization Studies: Examination of the Human Liver Microsomal Metabolism of the Non-Tricyclic Anti-Depressant Nefazodone Using Data-Dependent Accurate Mass Measurements

Cyclooxygenase 2 inhibitors: discovery, selectivity and the future

Inhibition of Hepatobiliary Transport as a Predictive Method for Clinical Hepatotoxicity of Nefazodone

Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition

Biochemically Based Design of Cyclooxygenase-2 (COX-2) Inhibitors: Facile Conversion of Nonsteroidal Antiinflammatory Drugs to Potent and Highly Selective COX-2 Inhibitors

Indolyl esters and amides related to indomethacin are selective COX-2 inhibitors

Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4

Aspirin-like Molecules that Covalently Inactivate Cyclooxygenase-2

IN VITRO METABOLISM STUDIES ON THE ISOXAZOLE RING SCISSION IN THE ANTI-INFLAMMATORY AGENT LEFLUNOMIDE TO ITS ACTIVE α-CYANOENOL METABOLITE A771726: MECHANISTIC SIMILARITIES WITH THE CYTOCHROME P450-CATALYZED DEHYDRATION OF ALDOXIMES

Discovery and design of selective cyclooxygenase-2 inhibitors as non-ulcerogenic, anti-inflammatory drugs with potential utility as anti-cancer agents

Identification of an N-methyl-4-phenylpyridinium-like metabolite of the antidiarrheal agent loperamide in human liver microsomes: underlying reason(s) for the lack of neurotoxicity despite the bioactivation event

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