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Transformation by the (R)―enantiomer of 2-hydroxyglutarate linked to EGLN activation

Nature (London), 2012-03, Vol.483 (7390), p.484-488

2012

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The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer

Nature reviews. Cancer, 2008-11, Vol.8 (11), p.865-873

Kaelin, Jr, William G

2008

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Publish houses of brick, not mansions of straw

Nature (London), 2017-05, Vol.545 (7655), p.387-387

Kaelin, Jr, William G

2017

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Targeting the HIF2-VEGF axis in renal cell carcinoma

Nature medicine, 2020-10, Vol.26 (10), p.1519-1530

2020

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Von Hippel–Lindau disease: insights into oxygen sensing, protein degradation, and cancer

The Journal of clinical investigation, 2022-09, Vol.132 (18)

Kaelin, William G.

2022

Volltextzugriff (PDF)

Common pitfalls in preclinical cancer target validation

Nature reviews. Cancer, 2017-07, Vol.17 (7), p.425

Kaelin, Jr, William G

2017

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VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400

Nature cell biology, 2008-03, Vol.10 (3), p.361-369

2008

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Influence of Metabolism on Epigenetics and Disease

Cell, 2013-03, Vol.153 (1), p.56-69

2013

Volltextzugriff (PDF)

2-Oxoglutarate-dependent dioxygenases in cancer

Nature reviews. Cancer, 2020-12, Vol.20 (12), p.710

2020

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Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1

Proceedings of the National Academy of Sciences - PNAS, 2011-08, Vol.108 (33), p.13379-13386

2011

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Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen

Proceedings of the National Academy of Sciences - PNAS, 2008-10, Vol.105 (43), p.16484-16489

2008

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Role for the p53 homologue p73 in E2F-1-induced apoptosis

Nature (London), 2000-10, Vol.407 (6804), p.645-648

2000

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The Concept of Synthetic Lethality in the Context of Anticancer Therapy

Nature reviews. Cancer, 2005-09, Vol.5 (9), p.689-698

Kaelin, William G

2005

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Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit

Nature cell biology, 2007-02, Vol.9 (2), p.225-232

2007

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Protocol to establish a genetically engineered mouse model of IDH1-mutant astrocytoma

STAR protocols, 2023-06, Vol.4 (2), p.102281-102281, Article 102281

2023

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Mitochondrial remodeling and ischemic protection by G protein-coupled receptor 35 agonists

Science (American Association for the Advancement of Science), 2022-08, Vol.377 (6606), p.621-629

2022

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The von Hippel-Lindau Tumor Suppressor Protein and Clear Cell Renal Carcinoma

Clinical cancer research, 2007-01, Vol.13 (2), p.680s-684s

Kaelin, Jr, William G

2007

Volltextzugriff (PDF)

A genetic mechanism for Tibetan high-altitude adaptation

Nature genetics, 2014-09, Vol.46 (9), p.951-956

2014

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Reactivation of Hepatic EPO Synthesis in Mice After PHD Loss

Science (American Association for the Advancement of Science), 2010-07, Vol.329 (5990), p.407-407

2010

Volltextzugriff (PDF)

von-Hippel Lindau and Hypoxia-Inducible Factor at the Center of Renal Cell Carcinoma Biology

Hematology/oncology clinics of North America, 2023-10, Vol.37 (5), p.809-825

2023

Volltextzugriff (PDF)

New cancer targets emerging from studies of the Von Hippel-Lindau tumor suppressor protein

Annals of the New York Academy of Sciences, 2010-10, Vol.1210 (1), p.1-7

Kaelin, Jr, William G.

2010

Volltextzugriff (PDF)

The von Hippel-Lindau protein, vascular endothelial growth factor, and kidney cancer

The New England journal of medicine, 2003-07, Vol.349 (5), p.419-421

2003

Volltextzugriff (PDF)

Patterns of Gene Expression and Copy-Number Alterations in von-Hippel Lindau Disease-Associated and Sporadic Clear Cell Carcinoma of the Kidney

Cancer research (Chicago, Ill.), 2009-06, Vol.69 (11), p.4674-4681

2009

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EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer

The EMBO journal, 2015-12, Vol.34 (23), p.2953-2970

2015

Volltextzugriff (PDF)

The Von Hippel-Lindau Tumor Suppressor Gene and Kidney Cancer

Clinical cancer research, 2004-09, Vol.10 (18), p.6290S-6295s

KAELIN, William G

2004

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Transformation by the (R)―enantiomer of 2-hydroxyglutarate linked to EGLN activation

The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer

Publish houses of brick, not mansions of straw

Targeting the HIF2-VEGF axis in renal cell carcinoma

Von Hippel–Lindau disease: insights into oxygen sensing, protein degradation, and cancer

Common pitfalls in preclinical cancer target validation

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400

Influence of Metabolism on Epigenetics and Disease

2-Oxoglutarate-dependent dioxygenases in cancer

Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1

Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen

Role for the p53 homologue p73 in E2F-1-induced apoptosis

The Concept of Synthetic Lethality in the Context of Anticancer Therapy

Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit

Protocol to establish a genetically engineered mouse model of IDH1-mutant astrocytoma

Mitochondrial remodeling and ischemic protection by G protein-coupled receptor 35 agonists

The von Hippel-Lindau Tumor Suppressor Protein and Clear Cell Renal Carcinoma

A genetic mechanism for Tibetan high-altitude adaptation

Reactivation of Hepatic EPO Synthesis in Mice After PHD Loss

von-Hippel Lindau and Hypoxia-Inducible Factor at the Center of Renal Cell Carcinoma Biology

New cancer targets emerging from studies of the Von Hippel-Lindau tumor suppressor protein

The von Hippel-Lindau protein, vascular endothelial growth factor, and kidney cancer

Patterns of Gene Expression and Copy-Number Alterations in von-Hippel Lindau Disease-Associated and Sporadic Clear Cell Carcinoma of the Kidney

EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer

The Von Hippel-Lindau Tumor Suppressor Gene and Kidney Cancer

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