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Systematic humanization of yeast genes reveals conserved functions and genetic modularity

Science (American Association for the Advancement of Science), 2015-05, Vol.348 (6237), p.921-925

2015

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Humanized yeast to model human biology, disease and evolution

Disease models & mechanisms, 2022-06, Vol.15 (6)

2022

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Humanization of yeast genes with multiple human orthologs reveals functional divergence between paralogs

PLoS biology, 2020-05, Vol.18 (5), p.e3000627-e3000627

2020

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Decoding human genetic variation using a synthetic paradigm

Nature reviews. Genetics, 2024-03, Vol.25 (3), p.163-163

Kachroo, Aashiq H

2024

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Systematic bacterialization of yeast genes identifies a near-universally swappable pathway

eLife, 2017-06, Vol.6

2017

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A Humanized Yeast Model for Studying TRAPP Complex Mutations; Proof-of-Concept Using Variants from an Individual with a TRAPPC1 -Associated Neurodevelopmental Syndrome

Cells (Basel, Switzerland), 2024-08, Vol.13 (17), p.1457

2024

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Yeast Cells Expressing the Human Mitochondrial DNA Polymerase Reveal Correlations between Polymerase Fidelity and Human Disease Progression

The Journal of biological chemistry, 2014-02, Vol.289 (9), p.5970-5985

2014

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Species-specific protein–protein interactions govern the humanization of the 20S proteasome in yeast

Genetics (Austin), 2023-08, Vol.225 (1)

2023

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Systematic Humanization of the Yeast Cytoskeleton Discerns Functionally Replaceable from Divergent Human Genes

Genetics (Austin), 2020-08, Vol.215 (4), p.1153-1169

2020

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An Overview of Tyrosine Site-specific Recombination: From an Flp Perspective

Microbiology spectrum, 2015-08, Vol.3 (4)

2015

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Functional Analysis of the Genes Encoding Diaminopropionate Ammonia Lyase in Escherichia coli and Salmonella enterica Serovar Typhimurium

Journal of Bacteriology, 2012-10, Vol.194 (20), p.5604-5612

2012

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Efforts to make and apply humanized yeast

Briefings in functional genomics, 2016-03, Vol.15 (2), p.155-163

2016

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The Many Nuanced Evolutionary Consequences of Duplicated Genes

Molecular biology and evolution, 2019-02, Vol.36 (2), p.304-314

2019

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Discovery of new vascular disrupting agents based on evolutionarily conserved drug action, pesticide resistance mutations, and humanized yeast

Genetics (Austin), 2021-09, Vol.219 (1)

2021

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Reactions of Cre with methylphosphonate DNA: similarities and contrasts with Flp and vaccinia topoisomerase

PloS one, 2009-09, Vol.4 (9), p.e7248-e7248

2009

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Hexapeptides That Inhibit Processing of Branched DNA Structures Induce a Dynamic Ensemble of Holliday Junction Conformations

The Journal of biological chemistry, 2015-09, Vol.290 (37), p.22734-22746

2015

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Rapid, scalable, combinatorial genome engineering by marker-less enrichment and recombination of genetically engineered loci in yeast

Cell reports methods, 2023-05, Vol.3 (5), p.100464, Article 100464

2023

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Single-step Precision Genome Editing in Yeast Using CRISPR-Cas9

Bio-protocol, 2018-03, Vol.8 (6)

2018

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Stereospecific suppression of active site mutants by methylphosphonate substituted substrates reveals the stereochemical course of site-specific DNA recombination

Nucleic acids research, 2015-07, Vol.43 (12), p.6023-6037

2015

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Metabolic engineering without plasmids

Nature biotechnology, 2009-08, Vol.27 (8), p.729-731

2009

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Electrostatic Suppression Allows Tyrosine Site-specific Recombination in the Absence of a Conserved Catalytic Arginine

The Journal of biological chemistry, 2010-07, Vol.285 (30), p.22976-22985

2010

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Mutations that alter the regulation of the chb operon of Escherichia coli allow utilization of cellobiose

Molecular microbiology, 2007-12, Vol.66 (6), p.1382-1395

2007

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The partitioning and copy number control systems of the selfish yeast plasmid: an optimized molecular design for stable persistence in host cells

Microbiology spectrum, 2014-10, Vol.2 (5)

2014

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Restoration of catalytic functions in Cre recombinase mutants by electrostatic compensation between active site and DNA substrate

Nucleic acids research, 2010-10, Vol.38 (19), p.6589-6601

2010

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Withdrawn as Duplicate: The many nuanced evolutionary consequences of duplicated genes

Molecular biology and evolution, 2018-12, Vol.35 (12), p.e1-e1

2018

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Systematic humanization of yeast genes reveals conserved functions and genetic modularity

Humanized yeast to model human biology, disease and evolution

Humanization of yeast genes with multiple human orthologs reveals functional divergence between paralogs

Decoding human genetic variation using a synthetic paradigm

Systematic bacterialization of yeast genes identifies a near-universally swappable pathway

A Humanized Yeast Model for Studying TRAPP Complex Mutations; Proof-of-Concept Using Variants from an Individual with a TRAPPC1 -Associated Neurodevelopmental Syndrome

Yeast Cells Expressing the Human Mitochondrial DNA Polymerase Reveal Correlations between Polymerase Fidelity and Human Disease Progression

Species-specific protein–protein interactions govern the humanization of the 20S proteasome in yeast

Systematic Humanization of the Yeast Cytoskeleton Discerns Functionally Replaceable from Divergent Human Genes

An Overview of Tyrosine Site-specific Recombination: From an Flp Perspective

Functional Analysis of the Genes Encoding Diaminopropionate Ammonia Lyase in Escherichia coli and Salmonella enterica Serovar Typhimurium

Efforts to make and apply humanized yeast

The Many Nuanced Evolutionary Consequences of Duplicated Genes

Discovery of new vascular disrupting agents based on evolutionarily conserved drug action, pesticide resistance mutations, and humanized yeast

Reactions of Cre with methylphosphonate DNA: similarities and contrasts with Flp and vaccinia topoisomerase

Hexapeptides That Inhibit Processing of Branched DNA Structures Induce a Dynamic Ensemble of Holliday Junction Conformations

Rapid, scalable, combinatorial genome engineering by marker-less enrichment and recombination of genetically engineered loci in yeast

Single-step Precision Genome Editing in Yeast Using CRISPR-Cas9

Stereospecific suppression of active site mutants by methylphosphonate substituted substrates reveals the stereochemical course of site-specific DNA recombination

Metabolic engineering without plasmids

Electrostatic Suppression Allows Tyrosine Site-specific Recombination in the Absence of a Conserved Catalytic Arginine

Mutations that alter the regulation of the chb operon of Escherichia coli allow utilization of cellobiose

The partitioning and copy number control systems of the selfish yeast plasmid: an optimized molecular design for stable persistence in host cells

Restoration of catalytic functions in Cre recombinase mutants by electrostatic compensation between active site and DNA substrate

Withdrawn as Duplicate: The many nuanced evolutionary consequences of duplicated genes

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