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How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function

Proceedings of the National Academy of Sciences - PNAS, 2013-10, Vol.110 (42), p.16808-16813

2013

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Discovery of Antibiotic (E)‑3-(3-Carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)‑one

Journal of the American Chemical Society, 2015-02, Vol.137 (5), p.1738-1741

2015

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Mechanism of anchoring of OmpA protein to the cell wall peptidoglycan of the gram‐negative bacterial outer membrane

The FASEB journal, 2012-01, Vol.26 (1), p.219-228

2012

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Combined In Silico and In Vitro Evidence Supporting an Aurora A Kinase Inhibitory Role of the Anti-Viral Drug Rilpivirine and an Anti-Proliferative Influence on Cancer Cells

Pharmaceuticals (Basel, Switzerland), 2022-09, Vol.15 (10), p.1186

2022

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Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly

Scientific reports, 2018-03, Vol.8 (1), p.4110-8, Article 4110

2018

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Discovery of 5-(2-(Phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one Derivatives as Potent Mnk2 Inhibitors: Synthesis, SAR Analysis and Biological Evaluation

ChemMedChem, 2014-05, Vol.9 (5), p.962-972

2014

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Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials

Bioorganic & medicinal chemistry letters, 2016-02, Vol.26 (3), p.1011-1015

2016

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Structural Analysis of the Role of Pseudomonas aeruginosa Penicillin-Binding Protein 5 in β-Lactam Resistance

Antimicrobial Agents and Chemotherapy, 2013-07, Vol.57 (7), p.3137-3146

2013

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Glycosylation at Asn211 Regulates the Activation State of the Discoidin Domain Receptor 1 (DDR1)

The Journal of biological chemistry, 2014-03, Vol.289 (13), p.9275-9287

2014

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Cyclin-Dependent Kinase 8: A New Hope in Targeted Cancer Therapy?: Miniperspective

Journal of medicinal chemistry, 2018-06, Vol.61 (12), p.5073-5092

2018

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Cyclin-Dependent Kinase 8: A New Hope in Targeted Cancer Therapy?

Journal of medicinal chemistry, 2018-06, Vol.61 (12), p.5073

2018

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Targeting CDK6 in cancer: State of the art and new insights

Cell cycle (Georgetown, Tex.), 2015-10, Vol.14 (20), p.3220-3230

2015

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Synthesis and Evaluation of 1,2,4-Triazolo[1,5‑a]pyrimidines as Antibacterial Agents Against Enterococcus faecium

Journal of medicinal chemistry, 2015-05, Vol.58 (10), p.4194-4203

2015

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Discoidin Domain Receptors: Unique Receptor Tyrosine Kinases in Collagen-mediated Signaling

The Journal of biological chemistry, 2013-03, Vol.288 (11), p.7430-7437

2013

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Targeting CDK9: a promising therapeutic opportunity in prostate cancer

Endocrine-related cancer, 2016-12, Vol.23 (12), p.T211-T226

2016

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MAP kinase-interacting kinases--emerging targets against cancer

Chemistry & biology, 2014-04, Vol.21 (4), p.441-452

2014

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Synthesis and biological evaluation of heteroaryl styryl sulfone derivatives as anticancer agents

Bioorganic & medicinal chemistry letters, 2016-12, Vol.26 (23), p.5674-5678

2016

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Discovery of a New Class of Non-β-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity

Journal of the American Chemical Society, 2014-03, Vol.136 (9), p.3664-3672

2014

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CDK5 in oncology: recent advances and future prospects

Future medicinal chemistry, 2017-10, Vol.9 (16), p.1939-1962

2017

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Discovery and pharmacological characterization of a novel series of highly selective inhibitors of cyclin‐dependent kinases 4 and 6 as anticancer agents

British journal of pharmacology, 2018-06, Vol.175 (12), p.2399-2413

2018

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Combined IIn Silico/I and IIn Vitro/I Evidence Supporting an Aurora A Kinase Inhibitory Role of the Anti-Viral Drug Rilpivirine and an Anti-Proliferative Influence on Cancer Cells

Pharmaceuticals (Basel, Switzerland), 2022-09, Vol.15 (10)

2022

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Discovery of 4-(dihydropyridinon-3-yl)amino-5-methylthieno[2,3-d]pyrimidine derivatives as potent Mnk inhibitors: synthesis, structure–activity relationship analysis and biological evaluation

European journal of medicinal chemistry, 2015-05, Vol.95, p.116-126

2015

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Dynamical insights of Mnk2 kinase activation by phosphorylation to facilitate inhibitor discovery

Future medicinal chemistry, 2015-01, Vol.7 (2), p.91-102

2015

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Shedding of Discoidin Domain Receptor 1 by Membrane-type Matrix Metalloproteinases

The Journal of biological chemistry, 2013-04, Vol.288 (17), p.12114-12129

2013

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In Search of Novel CDK8 Inhibitors by Virtual Screening

Journal of chemical information and modeling, 2017-03, Vol.57 (3), p.413-416

2017

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How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function

Discovery of Antibiotic (E)‑3-(3-Carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)‑one

Mechanism of anchoring of OmpA protein to the cell wall peptidoglycan of the gram‐negative bacterial outer membrane

Combined In Silico and In Vitro Evidence Supporting an Aurora A Kinase Inhibitory Role of the Anti-Viral Drug Rilpivirine and an Anti-Proliferative Influence on Cancer Cells

Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly

Discovery of 5-(2-(Phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one Derivatives as Potent Mnk2 Inhibitors: Synthesis, SAR Analysis and Biological Evaluation

Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials

Structural Analysis of the Role of Pseudomonas aeruginosa Penicillin-Binding Protein 5 in β-Lactam Resistance

Glycosylation at Asn211 Regulates the Activation State of the Discoidin Domain Receptor 1 (DDR1)

Cyclin-Dependent Kinase 8: A New Hope in Targeted Cancer Therapy?: Miniperspective

Cyclin-Dependent Kinase 8: A New Hope in Targeted Cancer Therapy?

Targeting CDK6 in cancer: State of the art and new insights

Synthesis and Evaluation of 1,2,4-Triazolo[1,5‑a]pyrimidines as Antibacterial Agents Against Enterococcus faecium

Discoidin Domain Receptors: Unique Receptor Tyrosine Kinases in Collagen-mediated Signaling

Targeting CDK9: a promising therapeutic opportunity in prostate cancer

MAP kinase-interacting kinases--emerging targets against cancer

Synthesis and biological evaluation of heteroaryl styryl sulfone derivatives as anticancer agents

Discovery of a New Class of Non-β-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity

CDK5 in oncology: recent advances and future prospects

Discovery and pharmacological characterization of a novel series of highly selective inhibitors of cyclin‐dependent kinases 4 and 6 as anticancer agents

Combined IIn Silico/I and IIn Vitro/I Evidence Supporting an Aurora A Kinase Inhibitory Role of the Anti-Viral Drug Rilpivirine and an Anti-Proliferative Influence on Cancer Cells

Discovery of 4-(dihydropyridinon-3-yl)amino-5-methylthieno[2,3-d]pyrimidine derivatives as potent Mnk inhibitors: synthesis, structure–activity relationship analysis and biological evaluation

Dynamical insights of Mnk2 kinase activation by phosphorylation to facilitate inhibitor discovery

Shedding of Discoidin Domain Receptor 1 by Membrane-type Matrix Metalloproteinases

In Search of Novel CDK8 Inhibitors by Virtual Screening

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