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Polymorphic human prostaglandin H synthase-2 proteins and their interactions with cyclooxygenase substrates and inhibitors

The pharmacogenomics journal, 2011-10, Vol.11 (5), p.337-347

2011

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Interaction between peroxidase and cyclooxygenase activities in prostaglandin-endoperoxide synthase. Interpretation of reaction kinetics

The Journal of biological chemistry, 1994-02, Vol.269 (8), p.5527-5536

1994

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Arabidopsis thaliana fatty acid alpha-dioxygenase-1: evaluation of substrates, inhibitors and amino-terminal function

Plant physiology and biochemistry, 2006-05, Vol.44 (5), p.284-293

2006

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Characterization of the tyrosyl radicals in ovine prostaglandin H synthase-1 by isotope replacement and site-directed mutagenesis

The Journal of biological chemistry, 1994-02, Vol.269 (7), p.5085-5091

1994

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Topography of prostaglandin H synthase. Antiinflammatory agents and the protease-sensitive arginine 253 region

The Journal of biological chemistry, 1989-08, Vol.264 (24), p.14136-14144

KULMACZ, R. J

1989

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Structural Characterization of a Pentadienyl Radical Intermediate Formed during Catalysis by Prostaglandin H Synthase-2

Journal of the American Chemical Society, 2001-04, Vol.123 (15), p.3609-3610

2001

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Tyrosine 385 of prostaglandin endoperoxide synthase is required for cyclooxygenase catalysis

The Journal of biological chemistry, 1990-11, Vol.265 (33), p.20073-20076

1990

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Prostaglandin H synthase. Kinetics of tyrosyl radical formation and of cyclooxygenase catalysis

The Journal of biological chemistry, 1992-09, Vol.267 (25), p.17753-17759

1992

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Distinct Influences of Carboxyl Terminal Segment Structure on Function in the Two Isoforms of Prostaglandin H Synthase

Archives of biochemistry and biophysics, 2000-12, Vol.384 (2), p.269-279

2000

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Constraints on prostaglandin biosynthesis in tissues

The Journal of biological chemistry, 1987-03, Vol.262 (8), p.3510-3517

1987

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Resonance Raman Studies Indicate a Unique Heme Active Site in Prostaglandin H Synthase

Biochemistry (Easton), 2000-10, Vol.39 (40), p.12424-12434

2000

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Primary structure of human thromboxane synthase determined from the cDNA sequence

The Journal of biological chemistry, 1992-01, Vol.267 (2), p.789-793

1992

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Tyrosyl radicals and their role in hydroperoxide-dependent activation and inactivation of prostaglandin endoperoxide synthase

Biochemistry (Easton), 1992-01, Vol.31 (1), p.3-7

1992

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Stoichiometry and kinetics of the interaction of prostaglandin H synthase with anti-inflammatory agents

The Journal of biological chemistry, 1985-10, Vol.260 (23), p.12572-12578

1985

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Heme spin states and peroxide-induced radical species in prostaglandin H synthase

The Journal of biological chemistry, 1987-08, Vol.262 (22), p.10524-10531

1987

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Heme coordination of prostaglandin H synthase

The Journal of biological chemistry, 1993-04, Vol.268 (12), p.8554-8563

1993

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Hydroperoxide Dependence and Cooperative Cyclooxygenase Kinetics in Prostaglandin H Synthase-1 and -2

The Journal of biological chemistry, 1999-07, Vol.274 (29), p.20301-20306

1999

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Amino-terminal topology of thromboxane synthase in the endoplasmic reticulum

The Journal of biological chemistry, 1993-09, Vol.268 (26), p.19483-19490

1993

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Prostaglandin H synthase and hydroperoxides: Peroxidase reaction and inactivation kinetics

Archives of biochemistry and biophysics, 1986-09, Vol.249 (2), p.273-285

Kulmacz, Richard J.

1986

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Prostaglandin H synthase: spectroscopic studies of the interaction with hydroperoxides and with indomethacin

Biochemistry (Easton), 1990-09, Vol.29 (37), p.8760-8771

1990

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Analysis of Hydroperoxide-Induced Tyrosyl Radicals and Lipoxygenase Activity in Aspirin-Treated Human Prostaglandin H Synthase-2

Biochemistry (Easton), 1997-02, Vol.36 (7), p.1836-1845

1997

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Prostaglandin H synthase: perturbation of the tyrosyl radical as a probe of anticyclooxygenase agents

Molecular pharmacology, 1991-11, Vol.40 (5), p.833-837

1991

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Prostaglandin H synthase. Stoichiometry of heme cofactor

The Journal of biological chemistry, 1984-05, Vol.259 (10), p.6358-6363

1984

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Cellular regulation of prostaglandin H synthase catalysis

FEBS Letters, 1998-07, Vol.430 (3), p.154-157

Kulmacz, Richard J

1998

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Prostaglandin H synthase. Effects of peroxidase cosubstrates on cyclooxygenase velocity

The Journal of biological chemistry, 2000-09, Vol.275 (36), p.27608-27614

2000

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Polymorphic human prostaglandin H synthase-2 proteins and their interactions with cyclooxygenase substrates and inhibitors

Interaction between peroxidase and cyclooxygenase activities in prostaglandin-endoperoxide synthase. Interpretation of reaction kinetics

Arabidopsis thaliana fatty acid alpha-dioxygenase-1: evaluation of substrates, inhibitors and amino-terminal function

Characterization of the tyrosyl radicals in ovine prostaglandin H synthase-1 by isotope replacement and site-directed mutagenesis

Topography of prostaglandin H synthase. Antiinflammatory agents and the protease-sensitive arginine 253 region

Structural Characterization of a Pentadienyl Radical Intermediate Formed during Catalysis by Prostaglandin H Synthase-2

Tyrosine 385 of prostaglandin endoperoxide synthase is required for cyclooxygenase catalysis

Prostaglandin H synthase. Kinetics of tyrosyl radical formation and of cyclooxygenase catalysis

Distinct Influences of Carboxyl Terminal Segment Structure on Function in the Two Isoforms of Prostaglandin H Synthase

Constraints on prostaglandin biosynthesis in tissues

Resonance Raman Studies Indicate a Unique Heme Active Site in Prostaglandin H Synthase

Primary structure of human thromboxane synthase determined from the cDNA sequence

Tyrosyl radicals and their role in hydroperoxide-dependent activation and inactivation of prostaglandin endoperoxide synthase

Stoichiometry and kinetics of the interaction of prostaglandin H synthase with anti-inflammatory agents

Heme spin states and peroxide-induced radical species in prostaglandin H synthase

Heme coordination of prostaglandin H synthase

Hydroperoxide Dependence and Cooperative Cyclooxygenase Kinetics in Prostaglandin H Synthase-1 and -2

Amino-terminal topology of thromboxane synthase in the endoplasmic reticulum

Prostaglandin H synthase and hydroperoxides: Peroxidase reaction and inactivation kinetics

Prostaglandin H synthase: spectroscopic studies of the interaction with hydroperoxides and with indomethacin

Analysis of Hydroperoxide-Induced Tyrosyl Radicals and Lipoxygenase Activity in Aspirin-Treated Human Prostaglandin H Synthase-2

Prostaglandin H synthase: perturbation of the tyrosyl radical as a probe of anticyclooxygenase agents

Prostaglandin H synthase. Stoichiometry of heme cofactor

Cellular regulation of prostaglandin H synthase catalysis

Prostaglandin H synthase. Effects of peroxidase cosubstrates on cyclooxygenase velocity

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