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Identification of a geldanamycin dimer that induces the selective degradation of HER-family tyrosine kinases

Cancer research (Chicago, Ill.), 2000-04, Vol.60 (8), p.2090-2094

2000

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Syntheses and Structure−Activity Relationships of the Second-Generation Antitumor Taxoids: Exceptional Activity against Drug-Resistant Cancer Cells

Journal of medicinal chemistry, 1996-09, Vol.39 (20), p.3889-3896

1996

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Synthesis and evaluation of geldanamycin-testosterone hybrids

Bioorganic & medicinal chemistry letters, 2000-06, Vol.10 (11), p.1303-1306

2000

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Synthesis and evaluation of geldanamycin-estradiol hybrids

Bioorganic & medicinal chemistry letters, 1999-05, Vol.9 (9), p.1233-1238

1999

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Syntheses and Structure−Activity Relationships of Taxoids Derived from 14β-Hydroxy-10-deacetylbaccatin III

Journal of medicinal chemistry, 1997-01, Vol.40 (3), p.267-278

1997

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Synthesis and Structure−Activity Relationships of Nonaromatic Taxoids: Effects of Alkyl and Alkenyl Ester Groups on Cytotoxicity

Journal of medicinal chemistry, 1997-01, Vol.40 (3), p.279-285

1997

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A Common Pharmacophore for Cytotoxic Natural Products That Stabilize Microtubules

Proceedings of the National Academy of Sciences - PNAS, 1999-04, Vol.96 (8), p.4256-4261

1999

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Desoxyepothilone B is Curative against Human Tumor Xenografts that are Refractory to Paclitaxel

Proceedings of the National Academy of Sciences - PNAS, 1998-12, Vol.95 (26), p.15798-15802

1998

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Total Synthesis and Antitumor Activity of 12,13-Desoxyepothilone F: An Unexpected Solvolysis Problem at C15, Mediated by Remote Substitution at C21

Journal of organic chemistry, 2000-10, Vol.65 (20), p.6525-6533

2000

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Probing Cell-Surface Architecture through Synthesis: An NMR-Determined Structural Motif for Tumor-Associated Mucins

Proceedings of the National Academy of Sciences - PNAS, 1999-03, Vol.96 (7), p.3489-3493

1999

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Identification of the Domains of Photoincorporation of the 3‘- and 7-Benzophenone Analogues of Taxol in the Carboxyl-Terminal Half of Murine mdr1b P-glycoprotein

Biochemistry (Easton), 1998-08, Vol.37 (32), p.11272-11279

1998

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Structural Requirements of Taxoids for Nitric Oxide and Tumor Necrosis Factor Production by Murine Macrophages

Biochemical and biophysical research communications, 1996-10, Vol.227 (1), p.227-235

1996

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Fully Synthetic Carbohydrate-Based Vaccines in Biochemically Relapsed Prostate Cancer: Clinical Trial Results With α-N-Acetylgalactosamine-O-Serine/Threonine Conjugate Vaccine

Journal of clinical oncology, 2003-12, Vol.21 (23), p.4292-4298

2003

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Tetrabutylammonium Salt Induced Denitration of Nitropyridines: Synthesis of Fluoro-, Hydroxy-, and Methoxypyridines

Organic letters, 2005-02, Vol.7 (4), p.577-579

2005

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Diels-Alder reaction of 2-cyano-1-aza dienes. The effect of nitrogen substituents

Journal of organic chemistry, 1993-04, Vol.58 (8), p.2075-2080

1993

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Principles of Mucin Architecture: Structural Studies on Synthetic Glycopeptides Bearing Clustered Mono-, Di-, Tri-, and Hexasaccharide Glycodomains

Journal of the American Chemical Society, 2002-08, Vol.124 (33), p.9833-9844

2002

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Bradykinin B1 Receptor Antagonists as Novel Analgesics: A Retrospective of Selected Medicinal Chemistry Developments

Current topics in medicinal chemistry, 2008-11, Vol.8 (16), p.1420-1430

2008

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Synthetic and Immunological Studies on Clustered Modes of Mucin-Related Tn and TF O-Linked Antigens: The Preparation of a Glycopeptide-Based Vaccine for Clinical Trials against Prostate Cancer

Journal of the American Chemical Society, 1998-12, Vol.120 (48), p.12474-12485

1998

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Asymmetric addition reactions of Grignard reagents to chiral 2-trifluoromethyl tert-butyl (Ellman) sulfinimine–ethanol adducts

Tetrahedron letters, 2006-04, Vol.47 (14), p.2377-2381

2006

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Reversal of diastereoselection in the addition of Grignard reagents to chiral 2-pyridyl tert-butyl (Ellman) sulfinimines

Tetrahedron letters, 2004-08, Vol.45 (35), p.6641-6643

2004

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A Broadly Applicable Method for the Efficient Synthesis of α-O-Linked Glycopeptides and Clustered Sialic Acid Residues

Journal of the American Chemical Society, 1999-03, Vol.121 (12), p.2662-2673

1999

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2,3-Diaminopyridine Bradykinin B1 Receptor Antagonists

Journal of medicinal chemistry, 2004-12, Vol.47 (26), p.6439-6442

2004

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2,3-Diaminopyridine Bradykinin B 1 Receptor Antagonists

Journal of medicinal chemistry, 2004-12, Vol.47 (26), p.6439-6442

2004

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New Chemical Synthesis of the Promising Cancer Chemotherapeutic Agent 12,13-Desoxyepothilone B: Discovery of a Surprising Long-Range Effect on the Diastereoselectivity of an Aldol Condensation

Journal of the American Chemical Society, 1999-08, Vol.121 (30), p.7050-7062

1999

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Development of Orally Bioavailable and CNS Penetrant Biphenylaminocyclopropane Carboxamide Bradykinin B sub(1) Receptor Antagonists

Journal of medicinal chemistry, 2007-01, Vol.50 (2), p.272-282

2007

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Identification of a geldanamycin dimer that induces the selective degradation of HER-family tyrosine kinases

Syntheses and Structure−Activity Relationships of the Second-Generation Antitumor Taxoids: Exceptional Activity against Drug-Resistant Cancer Cells

Synthesis and evaluation of geldanamycin-testosterone hybrids

Synthesis and evaluation of geldanamycin-estradiol hybrids

Syntheses and Structure−Activity Relationships of Taxoids Derived from 14β-Hydroxy-10-deacetylbaccatin III

Synthesis and Structure−Activity Relationships of Nonaromatic Taxoids: Effects of Alkyl and Alkenyl Ester Groups on Cytotoxicity

A Common Pharmacophore for Cytotoxic Natural Products That Stabilize Microtubules

Desoxyepothilone B is Curative against Human Tumor Xenografts that are Refractory to Paclitaxel

Total Synthesis and Antitumor Activity of 12,13-Desoxyepothilone F: An Unexpected Solvolysis Problem at C15, Mediated by Remote Substitution at C21

Probing Cell-Surface Architecture through Synthesis: An NMR-Determined Structural Motif for Tumor-Associated Mucins

Identification of the Domains of Photoincorporation of the 3‘- and 7-Benzophenone Analogues of Taxol in the Carboxyl-Terminal Half of Murine mdr1b P-glycoprotein

Structural Requirements of Taxoids for Nitric Oxide and Tumor Necrosis Factor Production by Murine Macrophages

Fully Synthetic Carbohydrate-Based Vaccines in Biochemically Relapsed Prostate Cancer: Clinical Trial Results With α-N-Acetylgalactosamine-O-Serine/Threonine Conjugate Vaccine

Tetrabutylammonium Salt Induced Denitration of Nitropyridines: Synthesis of Fluoro-, Hydroxy-, and Methoxypyridines

Diels-Alder reaction of 2-cyano-1-aza dienes. The effect of nitrogen substituents

Principles of Mucin Architecture: Structural Studies on Synthetic Glycopeptides Bearing Clustered Mono-, Di-, Tri-, and Hexasaccharide Glycodomains

Bradykinin B1 Receptor Antagonists as Novel Analgesics: A Retrospective of Selected Medicinal Chemistry Developments

Synthetic and Immunological Studies on Clustered Modes of Mucin-Related Tn and TF O-Linked Antigens: The Preparation of a Glycopeptide-Based Vaccine for Clinical Trials against Prostate Cancer

Asymmetric addition reactions of Grignard reagents to chiral 2-trifluoromethyl tert-butyl (Ellman) sulfinimine–ethanol adducts

Reversal of diastereoselection in the addition of Grignard reagents to chiral 2-pyridyl tert-butyl (Ellman) sulfinimines

A Broadly Applicable Method for the Efficient Synthesis of α-O-Linked Glycopeptides and Clustered Sialic Acid Residues

2,3-Diaminopyridine Bradykinin B1 Receptor Antagonists

2,3-Diaminopyridine Bradykinin B 1 Receptor Antagonists

New Chemical Synthesis of the Promising Cancer Chemotherapeutic Agent 12,13-Desoxyepothilone B: Discovery of a Surprising Long-Range Effect on the Diastereoselectivity of an Aldol Condensation

Development of Orally Bioavailable and CNS Penetrant Biphenylaminocyclopropane Carboxamide Bradykinin B sub(1) Receptor Antagonists

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