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Inhibitors of Pantothenate Kinase: Novel Antibiotics for Staphylococcal Infections

Antimicrobial Agents and Chemotherapy, 2003-06, Vol.47 (6), p.2051-2055

2003

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Identification of small molecule inhibitors of the hepatitis C virus RNA-dependent RNA polymerase from a pyrrolidine combinatorial mixture

Bioorganic & medicinal chemistry letters, 2005-03, Vol.15 (6), p.1553-1556

2005

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Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity

Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (7), p.1930-1933

2007

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Direct design of a potent non-peptide fibrinogen receptor antagonist based on the structure and conformation of a highly constrained cyclic RGD peptide

Journal of the American Chemical Society, 1993-09, Vol.115 (19), p.8861-8862

1993

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Conformational Preferences in a Benzodiazepine Series of Potent Nonpeptide Fibrinogen Receptor Antagonists

Journal of medicinal chemistry, 1999-02, Vol.42 (4), p.545-559

1999

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Enantiospecific synthesis of SB 214857, a potent, orally active, nonpeptide fibrinogen receptor antagonist

Tetrahedron letters, 1995-12, Vol.36 (52), p.9433-9436

1995

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An alternate enantiospecific synthesis of methyl (S)-7-tert-butoxycarbonyl-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetate

Tetrahedron letters, 1997-05, Vol.38 (18), p.3131-3134

1997

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Stereospecific synthesis of leukotriene antagonists

Journal of organic chemistry, 1989-07, Vol.54 (14), p.3487-3491

1989

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Synthesis and LTD4 antagonist activity of 2-norleukotriene analogs

Journal of medicinal chemistry, 1985-12, Vol.28 (12), p.1847-1853

1985

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Conformationally Constrained Peptides and Semipeptides Derived from RGD as Potent Inhibitors of the Platelet Fibrinogen Receptor and Platelet Aggregation

Journal of medicinal chemistry, 1994-03, Vol.37 (6), p.769-780

1994

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Potent non-peptide fibrinogen receptor antagonists which present an alternative pharmacophore

Journal of medicinal chemistry, 1995-01, Vol.38 (1), p.9-12

1995

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Orally Active and Potent Inhibitors of γ-Aminobutyric Acid Uptake

Journal of medicinal chemistry, 1985-05, Vol.28 (5), p.653-660

1985

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6-(Phenylthio)-substituted 2,3,4,5-tetrahydro-1H-3-benzazepines, a novel class of dopamine receptor antagonists and neuroleptics

Journal of medicinal chemistry, 1980-09, Vol.23 (9), p.975-976

1980

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Preclinical pharmacokinetics and interspecies scaling of a novel vitronectin receptor antagonist

Drug metabolism and disposition, 1999-11, Vol.27 (11), p.1232

1999

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Potent, Selective, Orally Active 3-Oxo-1,4-benzodiazepine GPIIb/IIIa Integrin Antagonists

Journal of medicinal chemistry, 1996-12, Vol.39 (25), p.4867-4870

1996

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Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model

Bioorganic & medicinal chemistry letters, 1999-07, Vol.9 (13), p.1807-1812

1999

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High-affinity leukotriene receptor antagonists. Synthesis and pharmacological characterization of 2-hydroxy-3-[(2-carboxyethyl)thio]-3-[2-(8-phenyloctyl)phenyl]propanoic acid

Journal of medicinal chemistry, 1987-06, Vol.30 (6), p.959-961

1987

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Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (αvβ3) antagonists

Bioorganic & medicinal chemistry letters, 1998-11, Vol.8 (22), p.3165-3170

1998

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Design of a potent and orally active nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist

Bioorganic & medicinal chemistry, 1994-09, Vol.2 (9), p.897-908

1994

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New synthesis of some arylthio-substituted 2,3,4,5-tetrahydro-1H-3-benzazepines

Journal of organic chemistry, 1982-09, Vol.47 (20), p.3862-3865

1982

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Structure-activity relationships in 3-oxo-1,4-benzodiazepine-2-acetic acid GPIIb/IIIa antagonists. The 2-benzazepine series

Bioorganic & medicinal chemistry letters, 1996-11, Vol.6 (21), p.2481-2486

1996

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AMINOGLYCOSIDES. V. SYNTHESIS OF GLUCOPYRANOSIDE DERIVATIVES OF NEAMINE MODIFIED IN THE 2-DEOXYSTREPTAMINE RING

The Journal of Antibiotics, 1981, Vol.34(1), pp.5-12

1981

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IMINOSULFURANES FROM BIOLOGICALLY ACTIVE SULFONAMIDES AND RELATED COMPOUNDS

Phosphorus and sulfur and the related elements, 1979-10, Vol.7 (2), p.195-201

1979

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2-nor-leukotriene analogs: antagonists of the airway and vascular smooth muscle effects of leukotriene C4, D4 and E4

Biochemical and biophysical research communications, 1983-12, Vol.117 (3), p.732-739

1983

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Synthesis and LTD4-antagonist activity of desamino-2-nor-leukotriene analogs

Prostaglandins, 1985, Vol.29 (1), p.75-81

1985

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Inhibitors of Pantothenate Kinase: Novel Antibiotics for Staphylococcal Infections

Identification of small molecule inhibitors of the hepatitis C virus RNA-dependent RNA polymerase from a pyrrolidine combinatorial mixture

Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity

Direct design of a potent non-peptide fibrinogen receptor antagonist based on the structure and conformation of a highly constrained cyclic RGD peptide

Conformational Preferences in a Benzodiazepine Series of Potent Nonpeptide Fibrinogen Receptor Antagonists

Enantiospecific synthesis of SB 214857, a potent, orally active, nonpeptide fibrinogen receptor antagonist

An alternate enantiospecific synthesis of methyl (S)-7-tert-butoxycarbonyl-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetate

Stereospecific synthesis of leukotriene antagonists

Synthesis and LTD4 antagonist activity of 2-norleukotriene analogs

Conformationally Constrained Peptides and Semipeptides Derived from RGD as Potent Inhibitors of the Platelet Fibrinogen Receptor and Platelet Aggregation

Potent non-peptide fibrinogen receptor antagonists which present an alternative pharmacophore

Orally Active and Potent Inhibitors of γ-Aminobutyric Acid Uptake

6-(Phenylthio)-substituted 2,3,4,5-tetrahydro-1H-3-benzazepines, a novel class of dopamine receptor antagonists and neuroleptics

Preclinical pharmacokinetics and interspecies scaling of a novel vitronectin receptor antagonist

Potent, Selective, Orally Active 3-Oxo-1,4-benzodiazepine GPIIb/IIIa Integrin Antagonists

Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model

High-affinity leukotriene receptor antagonists. Synthesis and pharmacological characterization of 2-hydroxy-3-[(2-carboxyethyl)thio]-3-[2-(8-phenyloctyl)phenyl]propanoic acid

Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (αvβ3) antagonists

Design of a potent and orally active nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist

New synthesis of some arylthio-substituted 2,3,4,5-tetrahydro-1H-3-benzazepines

Structure-activity relationships in 3-oxo-1,4-benzodiazepine-2-acetic acid GPIIb/IIIa antagonists. The 2-benzazepine series

AMINOGLYCOSIDES. V. SYNTHESIS OF GLUCOPYRANOSIDE DERIVATIVES OF NEAMINE MODIFIED IN THE 2-DEOXYSTREPTAMINE RING

IMINOSULFURANES FROM BIOLOGICALLY ACTIVE SULFONAMIDES AND RELATED COMPOUNDS

2-nor-leukotriene analogs: antagonists of the airway and vascular smooth muscle effects of leukotriene C4, D4 and E4

Synthesis and LTD4-antagonist activity of desamino-2-nor-leukotriene analogs

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