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Preponderance of Thiopurine S-Methyltransferase Deficiency and Heterozygosity Among Patients Intolerant to Mercaptopurine or Azathioprine

Journal of clinical oncology, 2001-04, Vol.19 (8), p.2293-2301

2001

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Structure and Dynamics of Thioguanine-modified Duplex DNA

The Journal of biological chemistry, 2003-01, Vol.278 (2), p.1005-1011

2003

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A Novel CRM1-mediated Nuclear Export Signal Governs Nuclear Accumulation of Glyceraldehyde-3-phosphate Dehydrogenase following Genotoxic Stress

The Journal of biological chemistry, 2004-02, Vol.279 (7), p.5984-5992

2004

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A nuclear protein complex containing high mobility group proteins B1 and B2, heat shock cognate protein 70, ERp60, and glyceraldehyde-3-phosphate dehydrogenase is involved in the cytotoxic response to DNA modified by incorporation of anticancer nucleoside analogues

Cancer research (Chicago, Ill.), 2003, Vol.63 (1), p.100-106

2003

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Polymorphism of the Thiopurine S-Methyltransferase Gene in African-Americans

Human molecular genetics, 1999-02, Vol.8 (2), p.371-376

1999

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Pharmacogenetics as a molecular basis for individualized drug therapy : The thiopurine S-methyltransferase paradigm

Pharmaceutical research, 1999-03, Vol.16 (3), p.342-349

1999

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Enhanced Proteolysis of Thiopurine S-methyltransferase (TPMT) Encoded by Mutant Alleles in Humans (TPMT3A, TPMT2): Mechanisms for the Genetic Polymorphism of TPMT Activity

Proceedings of the National Academy of Sciences - PNAS, 1997-06, Vol.94 (12), p.6444-6449

1997

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Msh2 Deficiency Attenuates But Does Not Abolish Thiopurine Hematopoietic Toxicity in Msh2-/- Mice

Molecular pharmacology, 2003-08, Vol.64 (2), p.456-465

2003

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Genetic Polymorphism of Thiopurine S-Methyltransferase: Molecular Mechanisms and Clinical Importance

Pharmacology, 2000-09, Vol.61 (3), p.136-146

2000

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A Single Point Mutation Leading to Loss of Catalytic Activity in Human Thiopurine S-Methyltransferase

Proceedings of the National Academy of Sciences - PNAS, 1995-02, Vol.92 (4), p.949-953

1995

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TPMT genetic variations in populations of the Russian Federation

Pediatric Blood & Cancer, 2009-02, Vol.52 (2), p.203-208

2009

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A Novel Protein Complex Distinct from Mismatch Repair Binds Thioguanylated DNA

Molecular pharmacology, 2001-02, Vol.59 (2), p.367-374

2001

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Human RNase H-Mediated RNA Cleavage from DNA-RNA Duplexes Is Inhibited by 6-Deoxythioguanosine Incorporation into DNA

Molecular pharmacology, 1999-10, Vol.56 (4), p.841-848

1999

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Thioguanine substitution alters DNA cleavage mediated by topoisomerase II

The FASEB journal, 2000-11, Vol.14 (14), p.2339-2344

2000

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Mercaptopurine Therapy Intolerance and Heterozygosity at the Thiopurine S-Methyltransferase Gene Locus

JNCI : Journal of the National Cancer Institute, 1999-12, Vol.91 (23), p.2001-2008

1999

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Promoter and intronic sequences of the human thiopurine S-methyltransferase (TPMT) gene isolated from a human PAC1 genomic library

Pharmaceutical research, 1997-12, Vol.14 (12), p.1672-1678

1997

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Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance

Annals of internal medicine, 1997-04, Vol.126 (8), p.608

1997

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Deoxythioguanosine triphosphate impairs HIV replication: a new mechanism for an old drug

The FASEB journal, 2001-09, Vol.15 (11), p.1902-1908

2001

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Molecular haplotyping of genomic DNA for multiple single-nucleotide polymorphisms located kilobases apart using long-range polymerase chain reaction and intramolecular ligation

Pharmacogenetics (London), 2002-03, Vol.12 (2), p.93-99

2002

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Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells

Cancer research (Chicago, Ill.), 2001-08, Vol.61 (15), p.5810-5816

2001

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Thiopurine S-methyltransferase deficiency : Two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians

American journal of human genetics, 1996-04, Vol.58 (4), p.694-702

1996

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Pharmacogenetics of Cancer Therapy: Getting Personal

American journal of human genetics, 1998-07, Vol.63 (1), p.11-16

1998

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Molecular cloning and functional characterization of the cDNA encoding the murine thiopurine S-methyltransferase (TPMT)

FEBS letters, 1998-03, Vol.424 (3), p.143-145

1998

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Reduced Folate Carrier Expression in Acute Lymphoblastic Leukemia: A Mechanism for Ploidy but not Lineage Differences in Methotrexate Accumulation

Blood, 1999-03, Vol.93 (5), p.1643-1650

1999

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Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells: mechanism for TPMT protein deficiency inherited by TPMT2, TPMT3A, TPMT3B or TPMT3C

Pharmacogenetics and genomics, 1999-10, Vol.9 (5), p.641-650

1999

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Preponderance of Thiopurine S-Methyltransferase Deficiency and Heterozygosity Among Patients Intolerant to Mercaptopurine or Azathioprine

Structure and Dynamics of Thioguanine-modified Duplex DNA

A Novel CRM1-mediated Nuclear Export Signal Governs Nuclear Accumulation of Glyceraldehyde-3-phosphate Dehydrogenase following Genotoxic Stress

A nuclear protein complex containing high mobility group proteins B1 and B2, heat shock cognate protein 70, ERp60, and glyceraldehyde-3-phosphate dehydrogenase is involved in the cytotoxic response to DNA modified by incorporation of anticancer nucleoside analogues

Polymorphism of the Thiopurine S-Methyltransferase Gene in African-Americans

Pharmacogenetics as a molecular basis for individualized drug therapy : The thiopurine S-methyltransferase paradigm

Enhanced Proteolysis of Thiopurine S-methyltransferase (TPMT) Encoded by Mutant Alleles in Humans (TPMT3A, TPMT2): Mechanisms for the Genetic Polymorphism of TPMT Activity

Msh2 Deficiency Attenuates But Does Not Abolish Thiopurine Hematopoietic Toxicity in Msh2-/- Mice

Genetic Polymorphism of Thiopurine S-Methyltransferase: Molecular Mechanisms and Clinical Importance

A Single Point Mutation Leading to Loss of Catalytic Activity in Human Thiopurine S-Methyltransferase

TPMT genetic variations in populations of the Russian Federation

A Novel Protein Complex Distinct from Mismatch Repair Binds Thioguanylated DNA

Human RNase H-Mediated RNA Cleavage from DNA-RNA Duplexes Is Inhibited by 6-Deoxythioguanosine Incorporation into DNA

Thioguanine substitution alters DNA cleavage mediated by topoisomerase II

Mercaptopurine Therapy Intolerance and Heterozygosity at the Thiopurine S-Methyltransferase Gene Locus

Promoter and intronic sequences of the human thiopurine S-methyltransferase (TPMT) gene isolated from a human PAC1 genomic library

Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance

Deoxythioguanosine triphosphate impairs HIV replication: a new mechanism for an old drug

Molecular haplotyping of genomic DNA for multiple single-nucleotide polymorphisms located kilobases apart using long-range polymerase chain reaction and intramolecular ligation

Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells

Thiopurine S-methyltransferase deficiency : Two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians

Pharmacogenetics of Cancer Therapy: Getting Personal

Molecular cloning and functional characterization of the cDNA encoding the murine thiopurine S-methyltransferase (TPMT)

Reduced Folate Carrier Expression in Acute Lymphoblastic Leukemia: A Mechanism for Ploidy but not Lineage Differences in Methotrexate Accumulation

Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells: mechanism for TPMT protein deficiency inherited by TPMT2, TPMT3A, TPMT3B or TPMT3C

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