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Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner

PloS one, 2016-01, Vol.11 (1), p.e0146618

2016

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C16-ceramide is a natural regulatory ligand of p53 in cellular stress response

Nature communications, 2018-10, Vol.9 (1), p.1-12, Article 4149

2018

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CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress

The Journal of biological chemistry, 2016-08, Vol.291 (32), p.16586-16596

2016

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A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

The Journal of neuroscience, 2008-01, Vol.28 (1), p.264-278

2008

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A novel tumor suppressor function of glycine N-methyltransferase is independent of its catalytic activity but requires nuclear localization

PloS one, 2013-07, Vol.8 (7), p.e70062-e70062

2013

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Exploratory Metabolomics Underscores the Folate Enzyme ALDH1L1 as a Regulator of Glycine and Methylation Reactions

Molecules (Basel, Switzerland), 2022-12, Vol.27 (23), p.8394

2022

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CHIP E3 ligase mediates proteasomal degradation of the proliferation regulatory protein ALDH1L1 during the transition of NIH3T3 fibroblasts from G0/G1 to S-phase

PloS one, 2018-07, Vol.13 (7), p.e0199699-e0199699

2018

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Molecular mechanisms underlying the potentially adverse effects of folate

Clinical chemistry and laboratory medicine, 2013-03, Vol.51 (3), p.607-616

2013

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Is ALDH1L1 Elevated in Lung Cancer? Comment on: Lee, S.-H.; et al. "The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer" Cancers 2020, 12 , 1382

Cancers, 2021-04, Vol.13 (7), p.1691

2021

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Rho GTPases RhoA and Rac1 Mediate Effects of Dietary Folate on Metastatic Potential of A549 Cancer Cells through the Control of Cofilin Phosphorylation

The Journal of biological chemistry, 2014-09, Vol.289 (38), p.26383-26394

2014

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The Role of Single-Nucleotide Polymorphisms in the Function of Candidate Tumor Suppressor ALDH1L1

Frontiers in genetics, 2019-10, Vol.10, p.1013-1013

2019

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Pancreatic islet protection at the expense of secretory function involves serine-linked mitochondrial one-carbon metabolism

Cell reports (Cambridge), 2023-06, Vol.42 (6), p.112615-112615, Article 112615

2023

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Pancreatic islet protection at the expense of secretory function involves serine-linked mitochondrial one-carbon metabolism

Cell reports (Cambridge), 2023-07, Vol.42 (7), p.112703-112703, Article 112703

2023

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Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype

Molecular cancer research, 2017-02, Vol.15 (2), p.189-200

2017

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Aldh1l2 knockout mouse metabolomics links the loss of the mitochondrial folate enzyme to deregulation of a lipid metabolism observed in rare human disorder

Human genomics, 2020-11, Vol.14 (1), p.41-41, Article 41

2020

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Knockout of Putative Tumor Suppressor Aldh1l1 in Mice Reprograms Metabolism to Accelerate Growth of Tumors in a Diethylnitrosamine (DEN) Model of Liver Carcinogenesis

Cancers, 2021-06, Vol.13 (13), p.3219

2021

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ALDH1L2 Is the Mitochondrial Homolog of 10-Formyltetrahydrofolate Dehydrogenase

The Journal of biological chemistry, 2010-07, Vol.285 (30), p.23056-23063

2010

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Structure of putative tumor suppressor ALDH1L1

Communications biology, 2022-01, Vol.5 (1), p.3-13, Article 3

2022

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Sex-Specific Metabolic Effects of Dietary Folate Withdrawal in Wild-Type and Aldh1l1 Knockout Mice

Metabolites, 2022-05, Vol.12 (5), p.454

2022

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Metabolic Response of Triple-Negative Breast Cancer to Folate Restriction

Nutrients, 2021-05, Vol.13 (5), p.1637

2021

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ALDH1L1 and ALDH1L2 Folate Regulatory Enzymes in Cancer

Alcohol and Cancer, 2018-01, Vol.1032, p.127-143

2018

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Loss of ALDH1L1 folate enzyme confers a selective metabolic advantage for tumor progression

Chemico-biological interactions, 2019-04, Vol.302, p.149-155

2019

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Folate pathways mediating the effects of ethanol in tumorigenesis

Chemico-biological interactions, 2020-06, Vol.324, p.109091-109091, Article 109091

2020

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Crystal Structures of the Carboxyl Terminal Domain of Rat 10-Formyltetrahydrofolate Dehydrogenase: Implications for the Catalytic Mechanism of Aldehyde Dehydrogenases

Biochemistry (Easton), 2007-03, Vol.46 (11), p.2917-2929

2007

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Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase

Molecular genetics and metabolism, 2007-05, Vol.91 (1), p.85-97

2007

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Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner

C16-ceramide is a natural regulatory ligand of p53 in cellular stress response

CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

A novel tumor suppressor function of glycine N-methyltransferase is independent of its catalytic activity but requires nuclear localization

Exploratory Metabolomics Underscores the Folate Enzyme ALDH1L1 as a Regulator of Glycine and Methylation Reactions

CHIP E3 ligase mediates proteasomal degradation of the proliferation regulatory protein ALDH1L1 during the transition of NIH3T3 fibroblasts from G0/G1 to S-phase

Molecular mechanisms underlying the potentially adverse effects of folate

Is ALDH1L1 Elevated in Lung Cancer? Comment on: Lee, S.-H.; et al. "The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer" Cancers 2020, 12 , 1382

Rho GTPases RhoA and Rac1 Mediate Effects of Dietary Folate on Metastatic Potential of A549 Cancer Cells through the Control of Cofilin Phosphorylation

The Role of Single-Nucleotide Polymorphisms in the Function of Candidate Tumor Suppressor ALDH1L1

Pancreatic islet protection at the expense of secretory function involves serine-linked mitochondrial one-carbon metabolism

Pancreatic islet protection at the expense of secretory function involves serine-linked mitochondrial one-carbon metabolism

Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype

Aldh1l2 knockout mouse metabolomics links the loss of the mitochondrial folate enzyme to deregulation of a lipid metabolism observed in rare human disorder

Knockout of Putative Tumor Suppressor Aldh1l1 in Mice Reprograms Metabolism to Accelerate Growth of Tumors in a Diethylnitrosamine (DEN) Model of Liver Carcinogenesis

ALDH1L2 Is the Mitochondrial Homolog of 10-Formyltetrahydrofolate Dehydrogenase

Structure of putative tumor suppressor ALDH1L1

Sex-Specific Metabolic Effects of Dietary Folate Withdrawal in Wild-Type and Aldh1l1 Knockout Mice

Metabolic Response of Triple-Negative Breast Cancer to Folate Restriction

ALDH1L1 and ALDH1L2 Folate Regulatory Enzymes in Cancer

Loss of ALDH1L1 folate enzyme confers a selective metabolic advantage for tumor progression

Folate pathways mediating the effects of ethanol in tumorigenesis

Crystal Structures of the Carboxyl Terminal Domain of Rat 10-Formyltetrahydrofolate Dehydrogenase: Implications for the Catalytic Mechanism of Aldehyde Dehydrogenases

Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase

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