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Dabrafenib plus trametinib in patients with BRAF V600E-mutant anaplastic thyroid cancer: updated analysis from the phase II ROAR basket study

Annals of oncology, 2022-04, Vol.33 (4), p.406-415

2022

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Phase I Trial of Recombinant Immunotoxin Anti-Tac(Fv)-PE38 (LMB-2) in Patients With Hematologic Malignancies

Journal of clinical oncology, 2000-04, Vol.18 (8), p.1622-1636

2000

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Intratumoral Administration of Recombinant Circularly Permuted Interleukin-4-Pseudomonas Exotoxin in Patients with High-Grade Glioma

Clinical cancer research, 2000-06, Vol.6 (6), p.2157-2165

2000

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Synaptic Integration Mediated by Striatal Cholinergic Interneurons in Basal Ganglia Function

Science (American Association for the Advancement of Science), 2000-07, Vol.289 (5479), p.633-637

2000

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Essential role for Bim in mediating the apoptotic and antitumor activities of immunotoxins

Oncogene, 2017-08, Vol.36 (35), p.4953-4962

2017

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Elevation of soluble CD307 (IRTA2 FcRH5) protein in the blood and expression on malignant cells of patients with multiple myeloma, chronic lymphocytic leukemia, and mantle cell lymphoma

Leukemia, 2007-01, Vol.21 (1), p.169-174

2007

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Targeted Toxins

Clinical cancer research, 2000-02, Vol.6 (2), p.326-334

2000

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Importance of the glutamate residue of KDEL in increasing the cytotoxicity of Pseudomonas exotoxin derivatives and for increased binding to the KDEL receptor

Biochemical journal, 1995-04, Vol.307 ( Pt 1) (1), p.29-37

1995

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Responses in Refractory Hairy Cell Leukemia to a Recombinant Immunotoxin

Blood, 1999-11, Vol.94 (10), p.3340-3348

1999

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Diphtheria toxin fused to human interleukin-3 is toxic to blasts from patients with myeloid leukemias

Leukemia, 2000-04, Vol.14 (4), p.576-585

2000

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Updated efficacy and safety data of dabrafenib (D) and trametinib (T) in patients (pts) with BRAF V600E–mutated anaplastic thyroid cancer (ATC)

Annals of oncology, 2018-10, Vol.29, p.viii645-viii646

2018

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Efficacy of the Anti-CD22 Recombinant Immunotoxin BL22 in Chemotherapy-Resistant Hairy-Cell Leukemia

The New England journal of medicine, 2001-07, Vol.345 (4), p.241-247

2001

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Toxin-labeled monoclonal antibodies

Current pharmaceutical biotechnology, 2001-12, Vol.2 (4), p.313

Kreitman, R J

2001

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Apoptosis induced by immunotoxins used in the treatment of hematologic malignancies

International journal of cancer, 2000-07, Vol.87 (1), p.86-94

2000

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Cytotoxic Activity of Disulfide-stabilized Recombinant Immunotoxin RFB4(dsFv)-PE38 (BL22) toward Fresh Malignant Cells from Patients with B-Cell Leukemias

Clinical cancer research, 2000-04, Vol.6 (4), p.1476-1487

2000

Volltextzugriff (PDF)

IL-4 receptors on human medulloblastoma tumours serve as a sensitive target for a circular permuted IL-4-Pseudomonas exotoxin fusion protein

British journal of cancer, 2002-01, Vol.86 (2), p.285-291

2002

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In Vitro Antibody Evolution Targeting Germline Hot Spots to Increase Activity of an Anti-CD22 Immunotoxin

The Journal of biological chemistry, 2005-01, Vol.280 (1), p.607-617

2005

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Targeting of Interleukin-13 Receptor on Human Renal Cell Carcinoma Cells by a Recombinant Chimeric Protein Composed of Interleukin-13 and a Truncated Form of Pseudomonas Exotoxin A (PE38QQR)

Blood, 1996-05, Vol.87 (10), p.4333-4339

1996

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Immunotoxins in cancer therapy

Current Opinion in Immunology, 1999-10, Vol.11 (5), p.570-578

Kreitman, Robert J

1999

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Complete regression of established human glioblastoma tumor xenograft by interleukin-4 toxin therapy

Cancer research (Chicago, Ill.), 1998-08, Vol.58 (16), p.3649-3653

1998

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Inhibition of TNF-alpha produced by Kupffer cells protects against the nonspecific liver toxicity of immunotoxin anti-Tac(Fv)-PE38, LMB-2

The Journal of immunology (1950), 2000-12, Vol.165 (12), p.7150-7156

2000

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Recombinant immunotoxins containing anti-Tac(Fv) and derivatives of Pseudomonas exotoxin produce complete regression in mice of an interleukin-2 receptor-expressing human carcinoma

Blood, 1994-01, Vol.83 (2), p.426-434

1994

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Recombinant toxins containing human granulocyte-macrophage colony-stimulating factor and either pseudomonas exotoxin or diphtheria toxin kill gastrointestinal cancer and leukemia cells

Blood, 1997-07, Vol.90 (1), p.252-259

1997

Volltextzugriff (PDF)

Preclinical development of a recombinant toxin containing circularly permuted interleukin 4 and truncated Pseudomonas exotoxin for therapy of malignant astrocytoma

Cancer research (Chicago, Ill.), 1996-12, Vol.56 (24), p.5631-5637

1996

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Anti-tumor activity of K1-LysPE38QQR, an immunotoxin targeting mesothelin, a cell-surface antigen overexpressed in ovarian cancer and malignant mesothelioma

Journal of immunotherapy, 2000-07, Vol.23 (4), p.473-479

2000

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Dabrafenib plus trametinib in patients with BRAF V600E-mutant anaplastic thyroid cancer: updated analysis from the phase II ROAR basket study

Phase I Trial of Recombinant Immunotoxin Anti-Tac(Fv)-PE38 (LMB-2) in Patients With Hematologic Malignancies

Intratumoral Administration of Recombinant Circularly Permuted Interleukin-4-Pseudomonas Exotoxin in Patients with High-Grade Glioma

Synaptic Integration Mediated by Striatal Cholinergic Interneurons in Basal Ganglia Function

Essential role for Bim in mediating the apoptotic and antitumor activities of immunotoxins

Elevation of soluble CD307 (IRTA2 FcRH5) protein in the blood and expression on malignant cells of patients with multiple myeloma, chronic lymphocytic leukemia, and mantle cell lymphoma

Targeted Toxins

Importance of the glutamate residue of KDEL in increasing the cytotoxicity of Pseudomonas exotoxin derivatives and for increased binding to the KDEL receptor

Responses in Refractory Hairy Cell Leukemia to a Recombinant Immunotoxin

Diphtheria toxin fused to human interleukin-3 is toxic to blasts from patients with myeloid leukemias

Updated efficacy and safety data of dabrafenib (D) and trametinib (T) in patients (pts) with BRAF V600E–mutated anaplastic thyroid cancer (ATC)

Efficacy of the Anti-CD22 Recombinant Immunotoxin BL22 in Chemotherapy-Resistant Hairy-Cell Leukemia

Toxin-labeled monoclonal antibodies

Apoptosis induced by immunotoxins used in the treatment of hematologic malignancies

Cytotoxic Activity of Disulfide-stabilized Recombinant Immunotoxin RFB4(dsFv)-PE38 (BL22) toward Fresh Malignant Cells from Patients with B-Cell Leukemias

IL-4 receptors on human medulloblastoma tumours serve as a sensitive target for a circular permuted IL-4-Pseudomonas exotoxin fusion protein

In Vitro Antibody Evolution Targeting Germline Hot Spots to Increase Activity of an Anti-CD22 Immunotoxin

Targeting of Interleukin-13 Receptor on Human Renal Cell Carcinoma Cells by a Recombinant Chimeric Protein Composed of Interleukin-13 and a Truncated Form of Pseudomonas Exotoxin A (PE38QQR)

Immunotoxins in cancer therapy

Complete regression of established human glioblastoma tumor xenograft by interleukin-4 toxin therapy

Inhibition of TNF-alpha produced by Kupffer cells protects against the nonspecific liver toxicity of immunotoxin anti-Tac(Fv)-PE38, LMB-2

Recombinant immunotoxins containing anti-Tac(Fv) and derivatives of Pseudomonas exotoxin produce complete regression in mice of an interleukin-2 receptor-expressing human carcinoma

Recombinant toxins containing human granulocyte-macrophage colony-stimulating factor and either pseudomonas exotoxin or diphtheria toxin kill gastrointestinal cancer and leukemia cells

Preclinical development of a recombinant toxin containing circularly permuted interleukin 4 and truncated Pseudomonas exotoxin for therapy of malignant astrocytoma

Anti-tumor activity of K1-LysPE38QQR, an immunotoxin targeting mesothelin, a cell-surface antigen overexpressed in ovarian cancer and malignant mesothelioma

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