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Flooding in river mouths: human caused or natural events? Five centuries of flooding events in the SW Netherlands, 1500–2000

Hydrology and earth system sciences, 2015-06, Vol.19 (6), p.2673-2684

de Kraker, A. M. J

2015

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A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase

Science (American Association for the Advancement of Science), 1994-08, Vol.265 (5175), p.1093-1095

1994

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Therapeutic targeting of Src-kinase Lyn in myeloid leukemic cell growth

Leukemia, 1999-06, Vol.13 (6), p.855-861

1999

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Investigating the correlation between monthly average temperatures and tithe proxy data from the Low Countries

Climatic change, 2013-07, Vol.119 (2), p.291-306

2013

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Inhibition of Src kinases by a selective tyrosine kinase inhibitor causes mitotic arrest

Cancer research (Chicago, Ill.), 1999-12, Vol.59 (24), p.6145-6152

1999

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Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors

Leukemia, 2002-09, Vol.16 (9), p.1589-1595

2002

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Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors

Journal of medicinal chemistry, 1997-07, Vol.40 (15), p.2296-2303

1997

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Src activation regulates anoikis in human colon tumor cell lines

Oncogene, 2002-11, Vol.21 (51), p.7797-7807

2002

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Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Journal of medicinal chemistry, 1998-10, Vol.41 (22), p.4365-4377

1998

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Structure−Activity Relationships for 1-Phenylbenzimidazoles as Selective ATP Site Inhibitors of the Platelet-Derived Growth Factor Receptor

Journal of medicinal chemistry, 1998-12, Vol.41 (27), p.5457-5465

1998

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Synthesis and structure-activity relationships of 7-substituted 3-(2, 6-dichlorophenyl)-1,6-naphthyridin-2(1H)-ones as selective inhibitors of pp60(c-src)

Journal of medicinal chemistry, 2000-08, Vol.43 (16), p.3134-3147

2000

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Structure−Activity Relationships for 5-Substituted 1-Phenylbenzimidazoles as Selective Inhibitors of the Platelet-Derived Growth Factor Receptor

Journal of medicinal chemistry, 1999-07, Vol.42 (13), p.2373-2382

1999

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Tyrosine Kinase Inhibitors. 6. Structure−Activity Relationships among N- and 3-Substituted 2,2‘-Diselenobis(1H-indoles) for Inhibition of Protein Tyrosine Kinases and Comparative in Vitro and in Vivo Studies against Selected Sulfur Congeners

Journal of medicinal chemistry, 1997-02, Vol.40 (4), p.413-426

1997

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Biochemical and cellular effects of c-Src kinase-selective pyrido[2,3- d]pyrimidine tyrosine kinase inhibitors

Biochemical pharmacology, 2000-10, Vol.60 (7), p.885-898

2000

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Synthesis, Structural Characterization, and Antitumor Properties of a Novel Class of Large-Ring Platinum(II) Chelate Complexes Incorporating the cis-1,4-Diaminocyclohexane Ligand in a Unique Locked Boat Conformation

Journal of medicinal chemistry, 1994-08, Vol.37 (17), p.2630-2636

1994

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Role of Tyrosine Kinase Activity of Epidermal Growth Factor Receptor in the Lysophosphatidic Acid-stimulated Mitogen-activated Protein Kinase Pathway

The Journal of biological chemistry, 1998-06, Vol.273 (23), p.14468-14475

1998

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2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity

Journal of medicinal chemistry, 1998-08, Vol.41 (17), p.3276-3292

1998

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Tyrosine Kinase Inhibitors. 9. Synthesis and Evaluation of Fused Tricyclic Quinazoline Analogues as ATP Site Inhibitors of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor

Journal of medicinal chemistry, 1996-02, Vol.39 (4), p.918-928

1996

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Pentostatin: future directions

Pharmacological reviews, 1992-12, Vol.44 (4), p.459

1992

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Transcriptional induction of the urokinase receptor gene by a constitutively active Src. Requirement of an upstream motif (-152/-135) bound with Sp1

The Journal of biological chemistry, 1999-06, Vol.274 (26), p.18428-18437

1999

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Ligand Substitution Reactions of Metallothioneins with EDTA and Apo-Carbonic Anhydrase

Proceedings of the National Academy of Sciences - PNAS, 1980-11, Vol.77 (11), p.6334-6338

1980

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Role of a small molecular weight phosphoprotein in the mechanism of action of CI‐994 (N‐acetyldinaline)

International journal of cancer, 1995-09, Vol.62 (5), p.636-642

1995

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Elevated DNA polymerase beta activity in a cis-diamminedichloroplatinum(II) resistant P388 murine leukemia cell line

Cancer letters, 1988, Vol.38 (3), p.307-314

1988

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3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamines and Related 2-Urea Derivatives Are Potent and Selective Inhibitors of the FGF Receptor-1 Tyrosine Kinase

Journal of medicinal chemistry, 2000-11, Vol.43 (22), p.4200-4211

2000

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Strategies for the discovery of novel tyrosine kinase inhibitors with anticancer activity

Anti-cancer drug design, 1994-08, Vol.9 (4), p.331

1994

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Flooding in river mouths: human caused or natural events? Five centuries of flooding events in the SW Netherlands, 1500–2000

A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase

Therapeutic targeting of Src-kinase Lyn in myeloid leukemic cell growth

Investigating the correlation between monthly average temperatures and tithe proxy data from the Low Countries

Inhibition of Src kinases by a selective tyrosine kinase inhibitor causes mitotic arrest

Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors

Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors

Src activation regulates anoikis in human colon tumor cell lines

Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Structure−Activity Relationships for 1-Phenylbenzimidazoles as Selective ATP Site Inhibitors of the Platelet-Derived Growth Factor Receptor

Synthesis and structure-activity relationships of 7-substituted 3-(2, 6-dichlorophenyl)-1,6-naphthyridin-2(1H)-ones as selective inhibitors of pp60(c-src)

Structure−Activity Relationships for 5-Substituted 1-Phenylbenzimidazoles as Selective Inhibitors of the Platelet-Derived Growth Factor Receptor

Tyrosine Kinase Inhibitors. 6. Structure−Activity Relationships among N- and 3-Substituted 2,2‘-Diselenobis(1H-indoles) for Inhibition of Protein Tyrosine Kinases and Comparative in Vitro and in Vivo Studies against Selected Sulfur Congeners

Biochemical and cellular effects of c-Src kinase-selective pyrido[2,3- d]pyrimidine tyrosine kinase inhibitors

Synthesis, Structural Characterization, and Antitumor Properties of a Novel Class of Large-Ring Platinum(II) Chelate Complexes Incorporating the cis-1,4-Diaminocyclohexane Ligand in a Unique Locked Boat Conformation

Role of Tyrosine Kinase Activity of Epidermal Growth Factor Receptor in the Lysophosphatidic Acid-stimulated Mitogen-activated Protein Kinase Pathway

2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity

Tyrosine Kinase Inhibitors. 9. Synthesis and Evaluation of Fused Tricyclic Quinazoline Analogues as ATP Site Inhibitors of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor

Pentostatin: future directions

Transcriptional induction of the urokinase receptor gene by a constitutively active Src. Requirement of an upstream motif (-152/-135) bound with Sp1

Ligand Substitution Reactions of Metallothioneins with EDTA and Apo-Carbonic Anhydrase

Role of a small molecular weight phosphoprotein in the mechanism of action of CI‐994 (N‐acetyldinaline)

Elevated DNA polymerase beta activity in a cis-diamminedichloroplatinum(II) resistant P388 murine leukemia cell line

3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamines and Related 2-Urea Derivatives Are Potent and Selective Inhibitors of the FGF Receptor-1 Tyrosine Kinase

Strategies for the discovery of novel tyrosine kinase inhibitors with anticancer activity

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