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Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase

PLoS neglected tropical diseases, 2019-11, Vol.13 (11), p.e0007894-e0007894

2019

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Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors

Journal of medicinal chemistry, 2019-04, Vol.62 (7), p.3407-3427

2019

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Design and Discovery of an Orally Efficacious Spiroindolinone-Based Tankyrase Inhibitor for the Treatment of Colon Cancer

Journal of medicinal chemistry, 2020-04, Vol.63 (8), p.4183-4204

2020

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Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents

Journal of medicinal chemistry, 2023-03, Vol.66 (6), p.4059-4085

2023

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BMP signaling is a therapeutic target in ovarian cancer

Cell death discovery, 2020-12, Vol.6 (1), p.139-139, Article 139

2020

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The ubiquinone synthesis pathway is a promising drug target for Chagas disease

PloS one, 2021-02, Vol.16 (2), p.e0243855-e0243855

2021

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Bis-Heteroaryl Pyrazoles: Identification of Orally Bioavailable Inhibitors of Activin Receptor-Like Kinase-2 (R206H)

Chemical and Pharmaceutical Bulletin, 2019/03/01, Vol.67(3), pp.224-235

2019

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Identification of small molecule inhibitors of human COQ7

Bioorganic & medicinal chemistry, 2020-01, Vol.28 (1), p.115182, Article 115182

2020

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A small molecule iCDM-34 identified by in silico screening suppresses HBV DNA through activation of aryl hydrocarbon receptor

Cell death discovery, 2023-12, Vol.9 (1), p.467-467, Article 467

2023

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Development of a degrader against oncogenic fusion protein FGFR3-TACC3

Bioorganic & medicinal chemistry letters, 2022-03, Vol.60, p.128584, Article 128584

2022

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Eradication of Central Nervous System Leukemia of T-Cell Origin with a Brain-Permeable LSD1 Inhibitor

Clinical cancer research, 2019-03, Vol.25 (5), p.1601-1611

2019

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Novel pharmacologic inhibition of lysine-specific demethylase 1 as a potential therapeutic for glioblastoma

Cancer gene therapy, 2024-11

2024

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New antimalarials identified by a cell-based phenotypic approach: Structure–activity relationships of 2,3,4,9-tetrahydro-1H-β-carboline derivatives possessing a 2-((coumarin-5-yl)oxy)alkanoyl moiety

Bioorganic & medicinal chemistry, 2022-07, Vol.66, p.116830-116830, Article 116830

2022

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Structure-based development of novel substrate-type G9a inhibitors as epigenetic modulators for sickle cell disease treatment

Bioorganic & medicinal chemistry letters, 2024-09, Vol.110, p.129856, Article 129856

2024

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Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles

ACS medicinal chemistry letters, 2022-05, Vol.13 (5), p.848-854

2022

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Novel bicyclic pyrazoles as potent ALK2 (R206H) inhibitors for the treatment of fibrodysplasia ossificans progressiva

Bioorganic & medicinal chemistry letters, 2021-04, Vol.38, p.127858-127858, Article 127858

2021

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OA-35 Discovery of a Novel Class MMSET Inhibitor With Specificity for t(4; 14)-Positive Multiple Myeloma

Clinical lymphoma, myeloma and leukemia, 2024-09, Vol.24, p.S22-S23

2024

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Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen

Bioorganic & medicinal chemistry, 2017-08, Vol.25 (16), p.4259-4264

2017

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Identification of pyrrolo[2,3-d]pyrimidines as potent HCK and FLT3-ITD dual inhibitors

Bioorganic & medicinal chemistry letters, 2017-11, Vol.27 (22), p.4994-4998

2017

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A novel synthetic approach toward the zaragozic acids core structure

Tetrahedron letters, 1994-12, Vol.35 (49), p.9185-9188

1994

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Synthesis of (-)-ambrox from ℓ-abietic acid

Tetrahedron letters, 1987, Vol.28 (25), p.2863-2866

1987

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(2R)-2-Ethylchromane-2-carboxylic Acids: Discovery of Novel PPARα/γ Dual Agonists as Antihyperglycemic and Hypolipidemic Agents

Journal of medicinal chemistry, 2004-06, Vol.47 (12), p.3255-3263

2004

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Versatile Synthesis of an Intermediate for the 1b-Methylcarbapenem Synthesis

Heterocycles, 1994, Vol.38 (2), p.277

1994

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(2 R)-2-Methylchromane-2-carboxylic acids: Discovery of selective PPARα agonists as hypolipidemic agents

Bioorganic & medicinal chemistry letters, 2005-07, Vol.15 (14), p.3347-3351

2005

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Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase

Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors

Design and Discovery of an Orally Efficacious Spiroindolinone-Based Tankyrase Inhibitor for the Treatment of Colon Cancer

Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents

BMP signaling is a therapeutic target in ovarian cancer

The ubiquinone synthesis pathway is a promising drug target for Chagas disease

Bis-Heteroaryl Pyrazoles: Identification of Orally Bioavailable Inhibitors of Activin Receptor-Like Kinase-2 (R206H)

Identification of small molecule inhibitors of human COQ7

Structural Basis of Activin Receptor-Like Kinase 2 (R206H) Inhibition by Bis-heteroaryl Pyrazole-Based Inhibitors for the Treatment of Fibrodysplasia Ossificans Progressiva Identified by the Integration of Ligand-Based and Structure-Based Drug Design Approaches

A small molecule iCDM-34 identified by in silico screening suppresses HBV DNA through activation of aryl hydrocarbon receptor

Development of a degrader against oncogenic fusion protein FGFR3-TACC3

Eradication of Central Nervous System Leukemia of T-Cell Origin with a Brain-Permeable LSD1 Inhibitor

Novel pharmacologic inhibition of lysine-specific demethylase 1 as a potential therapeutic for glioblastoma

New antimalarials identified by a cell-based phenotypic approach: Structure–activity relationships of 2,3,4,9-tetrahydro-1H-β-carboline derivatives possessing a 2-((coumarin-5-yl)oxy)alkanoyl moiety

Structure-based development of novel substrate-type G9a inhibitors as epigenetic modulators for sickle cell disease treatment

Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles

Novel bicyclic pyrazoles as potent ALK2 (R206H) inhibitors for the treatment of fibrodysplasia ossificans progressiva

OA-35 Discovery of a Novel Class MMSET Inhibitor With Specificity for t(4; 14)-Positive Multiple Myeloma

Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen

Identification of pyrrolo[2,3-d]pyrimidines as potent HCK and FLT3-ITD dual inhibitors

A novel synthetic approach toward the zaragozic acids core structure

Synthesis of (-)-ambrox from ℓ-abietic acid

(2R)-2-Ethylchromane-2-carboxylic Acids: Discovery of Novel PPARα/γ Dual Agonists as Antihyperglycemic and Hypolipidemic Agents

Versatile Synthesis of an Intermediate for the 1b-Methylcarbapenem Synthesis

(2 R)-2-Methylchromane-2-carboxylic acids: Discovery of selective PPARα agonists as hypolipidemic agents

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