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An Age-Dependent Physiologically Based Pharmacokinetic/Pharmacodynamic Model for the Organophosphorus Insecticide Chlorpyrifos in the Preweanling Rat

Toxicological sciences, 2007-08, Vol.98 (2), p.348-365

2007

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Age-Related Brain Cholinesterase Inhibition Kinetics following In Vitro Incubation with Chlorpyrifos-Oxon and Diazinon-Oxon

Toxicological sciences, 2007-01, Vol.95 (1), p.147-155

2007

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Cyclic conversion of the novel Src kinase inhibitor [7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine (TG100435) and Its N-oxide metabolite by flavin-containing monoxygenases and cytochrome P450 reductase

Drug metabolism and disposition, 2007-12, Vol.35 (12), p.2242

2007

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Development of a non-invasive biomonitoring approach to determine exposure to the organophosphorus insecticide chlorpyrifos in rat saliva

Toxicology and applied pharmacology, 2007-03, Vol.219 (2), p.217-225

2007

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Noninvasive Biomonitoring Approaches to Determine Dosimetry and Risk Following Acute Chemical Exposure: Analysis of Lead or Organophosphate Insecticide in Saliva

Journal of Toxicology and Environmental Health, Part A, 2004-04, Vol.67 (8-10), p.635-650

2004

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Metabolism and pharmacokinetics of a novel Src kinase inhibitor TG100435 ([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and its active N-oxide metabolite TG100855 ([7-(2,6-dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)

Drug metabolism and disposition, 2007-06, Vol.35 (6), p.929

2007

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Reply to Letter to the Editor

Toxicological sciences, 2007-08, Vol.98 (2), p.605-606

Kousba, Ahmed

2007

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A 9-Month Toxicity and Toxicokinetic Assessment of Subcutaneous Pegylated Human C-peptide (CBX129801) in Cynomolgus Monkeys

International journal of toxicology, 2015-07, Vol.34 (4), p.318-324

2015

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In Vitro Rat Hepatic and Intestinal Metabolism of the Organophosphate Pesticides Chlorpyrifos and Diazinon

Toxicological sciences, 2003-04, Vol.72 (2), p.193-200

2003

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Physiologically Based Pharmacokinetic/Pharmacodynamic Model for the Organophosphorus Pesticide Diazinon

Neurotoxicology (Park Forest South), 2004-12, Vol.25 (6), p.1013-1030

2004

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Phase I study of intravenously administered ATI-1123, a liposomal docetaxel formulation in patients with advanced solid tumors

Cancer chemotherapy and pharmacology, 2014-12, Vol.74 (6), p.1241-1250

2014

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Age-dependent pharmacokinetic and pharmacodynamic response in preweanling rats following oral exposure to the organophosphorus insecticide chlorpyrifos

Toxicology (Amsterdam), 2006-03, Vol.220 (1), p.13-25

2006

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Comparison of Chlorpyrifos-Oxon and Paraoxon Acetylcholinesterase Inhibition Dynamics: Potential Role of a Peripheral Binding Site

Toxicological sciences, 2004-08, Vol.80 (2), p.239-248

2004

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Characterization of the in vitro kinetic interaction of chlorpyrifos-oxon with rat salivary cholinesterase: A potential biomonitoring matrix

Toxicology (Amsterdam), 2003-06, Vol.188 (2), p.219-232

2003

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The overlooked contribution of Flavin‐containing Monoxygenases in the determination of total metabolic flux

The FASEB journal, 2008-03, Vol.22 (S1)

2008

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Cyclic Conversion of the Novel Src Kinase Inhibitor TG100435 and Its N‐Oxide Metabolite by Flavin‐Containing Monoxygenases and Cytochrome P450 Reductase

The FASEB journal, 2008-03, Vol.22 (S1)

2008

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Abstract B191: Phase 1 pharmacokinetic (PK) assessments of ATI-1123, a novel human serum albumin-stabilized nanoparticle docetaxel liposomal formulation, in patients with advanced solid malignancies

Molecular cancer therapeutics, 2011-11, Vol.10 (11_Supplement), p.B191-B191

2011

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Interactions of rat brain acetylcholinesterase with the detergent Triton X-100 and the organophosphate paraoxon

Toxicological sciences, 2001-10, Vol.63 (2), p.208-213

2001

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Development of a non-invasive biomonitoring approach to determine exposure to the organophosphorus insecticide chlorpyrifos in rat saliva: Anticholinesterases

Toxicology and applied pharmacology, 2007, Vol.219 (2-3), p.217-225

2007

Volltextzugriff (PDF)

Identification of the enzyme isoforms responsible for in vitro metabolism of the anti‐cancer agent TG100435 using human liver microsomes and recombinant enzymes

The FASEB journal, 2006-03, Vol.20 (5), p.LB108-LB108

2006

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Comparison of the in vitro metabolism of TG100435 and TG100855 by human liver, intestine and lung microsomes

The FASEB journal, 2006-03, Vol.20 (5), p.LB108-LB108

2006

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Species differences in FMO and CYP enzymes metabolism of TG100435

The FASEB journal, 2006-03, Vol.20 (5), p.LB107-LB108

2006

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Negative Ion Chemical Ionization Mass Spectrometry for the Analysis of 3,5,6-Trichloro-2-pyridinol in Saliva of Rats Exposed to Chlorpyrifos

Analytical letters, 2005-04, Vol.38 (6), p.939-949

2005

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An Age-Dependent Physiologically Based Pharmacokinetic/Pharmacodynamic Model for the Organophosphorus Insecticide Chlorpyrifos in the Preweanling Rat

Age-Related Brain Cholinesterase Inhibition Kinetics following In Vitro Incubation with Chlorpyrifos-Oxon and Diazinon-Oxon

Cyclic conversion of the novel Src kinase inhibitor [7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine (TG100435) and Its N-oxide metabolite by flavin-containing monoxygenases and cytochrome P450 reductase

Development of a non-invasive biomonitoring approach to determine exposure to the organophosphorus insecticide chlorpyrifos in rat saliva

Development of Prodrug 4-Chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl Benzoate (TG100801): A Topically Administered Therapeutic Candidate in Clinical Trials for the Treatment of Age-Related Macular Degeneration

Noninvasive Biomonitoring Approaches to Determine Dosimetry and Risk Following Acute Chemical Exposure: Analysis of Lead or Organophosphate Insecticide in Saliva

Reply to Letter to the Editor

A 9-Month Toxicity and Toxicokinetic Assessment of Subcutaneous Pegylated Human C-peptide (CBX129801) in Cynomolgus Monkeys

In Vitro Rat Hepatic and Intestinal Metabolism of the Organophosphate Pesticides Chlorpyrifos and Diazinon

Physiologically Based Pharmacokinetic/Pharmacodynamic Model for the Organophosphorus Pesticide Diazinon

Phase I study of intravenously administered ATI-1123, a liposomal docetaxel formulation in patients with advanced solid tumors

Age-dependent pharmacokinetic and pharmacodynamic response in preweanling rats following oral exposure to the organophosphorus insecticide chlorpyrifos

Comparison of Chlorpyrifos-Oxon and Paraoxon Acetylcholinesterase Inhibition Dynamics: Potential Role of a Peripheral Binding Site

Characterization of the in vitro kinetic interaction of chlorpyrifos-oxon with rat salivary cholinesterase: A potential biomonitoring matrix

The overlooked contribution of Flavin‐containing Monoxygenases in the determination of total metabolic flux

Cyclic Conversion of the Novel Src Kinase Inhibitor TG100435 and Its N‐Oxide Metabolite by Flavin‐Containing Monoxygenases and Cytochrome P450 Reductase

Abstract B191: Phase 1 pharmacokinetic (PK) assessments of ATI-1123, a novel human serum albumin-stabilized nanoparticle docetaxel liposomal formulation, in patients with advanced solid malignancies

Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine—a potent, orally active Src kinase inhibitor with anti-tumor activity in preclinical assays

Interactions of rat brain acetylcholinesterase with the detergent Triton X-100 and the organophosphate paraoxon

Development of a non-invasive biomonitoring approach to determine exposure to the organophosphorus insecticide chlorpyrifos in rat saliva: Anticholinesterases

Identification of the enzyme isoforms responsible for in vitro metabolism of the anti‐cancer agent TG100435 using human liver microsomes and recombinant enzymes

Comparison of the in vitro metabolism of TG100435 and TG100855 by human liver, intestine and lung microsomes

Species differences in FMO and CYP enzymes metabolism of TG100435

Negative Ion Chemical Ionization Mass Spectrometry for the Analysis of 3,5,6-Trichloro-2-pyridinol in Saliva of Rats Exposed to Chlorpyrifos

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