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Design, Synthesis, and Antiviral Activity of α-Nucleosides: d- and l-Isomers of Lyxofuranosyl- and (5-Deoxylyxofuranosyl)benzimidazoles

Journal of medicinal chemistry, 1998-04, Vol.41 (8), p.1242-1251

1998

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Potent and Selective Inhibition of Human Cytomegalovirus Replication by 1263W94, a Benzimidazole l-Riboside with a Unique Mode of Action

Antimicrobial Agents and Chemotherapy, 2002-08, Vol.46 (8), p.2365-2372

2002

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Synthesis and Antiviral Evaluation of Halogenated β-d- and -l-Erythrofuranosylbenzimidazoles

Journal of medicinal chemistry, 2000-06, Vol.43 (12), p.2464-2472

2000

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Pharmacokinetics of the thymidine analog 2′-fluoro-5-methyl-1-β- d-arabinofuranosyluracil (FMAU) in tumor-bearing rats

Nuclear medicine and biology, 2004-05, Vol.31 (4), p.407-418

2004

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Design of Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase with Improved Drug Resistance Properties. 2

Journal of medicinal chemistry, 2004-11, Vol.47 (24), p.5923-5936

2004

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Synthesis and Antiviral Activity of 2‘-Deoxy-4‘-thio Purine Nucleosides

Journal of medicinal chemistry, 1996-01, Vol.39 (2), p.538-542

1996

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Influence of stereochemistry on antiviral activities and resistance profiles of dideoxycytidine nucleosides

Antimicrobial Agents and Chemotherapy, 1994-04, Vol.38 (4), p.868-871

1994

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Preclinical and Toxicology Studies of 1263W94, a Potent and Selective Inhibitor of Human Cytomegalovirus Replication

Antimicrobial Agents and Chemotherapy, 2002-08, Vol.46 (8), p.2373-2380

2002

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Anti-human immunodeficiency virus synergism by zidovudine (3'-azidothymidine) and didanosine (dideoxyinosine) contrasts with their additive inhibition of normal human marrow progenitor cells

Antimicrobial Agents and Chemotherapy, 1991-02, Vol.35 (2), p.322-328

1991

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The crystal structure of Escherichia coli purine nucleoside phosphorylase: a comparison with the human enzyme reveals a conserved topology

Structure (London), 1997-10, Vol.5 (10), p.1373-1383

1997

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6-Methoxypurine arabinoside as a selective and potent inhibitor of varicella-zoster virus

Antimicrobial Agents and Chemotherapy, 1991-05, Vol.35 (5), p.851-857

1991

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Metabolic disposition and pharmacokinetics of the antiviral agent 6-methoxypurine arabinoside in rats and monkeys

Antimicrobial Agents and Chemotherapy, 1991-06, Vol.35 (6), p.1165-1173

1991

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Imidazo[4,5-c]pyridines (3-deazapurines) and their nucleosides as immunosuppressive and antiinflammatory agents

Journal of medicinal chemistry, 1986-01, Vol.29 (1), p.138-143

1986

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6-N-substituted derivatives of adenine arabinoside as selective inhibitors of varicella-zoster virus

Antimicrobial Agents and Chemotherapy, 1991-07, Vol.35 (7), p.1437-1443

1991

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Metabolism and pharmacokinetics of the anti-varicella-zoster virus agent 6-dimethylaminopurine arabinoside

Antimicrobial Agents and Chemotherapy, 1992-02, Vol.36 (2), p.353-360

1992

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Crystallization and preliminary X-ray investigation of uridine phosphorylase from Escherichia coli

The Journal of biological chemistry, 1987-02, Vol.262 (6), p.2852-2853

1987

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Purification and properties of inosine-guanosine phosphorylase from Escherichia coli K-12

Journal of Bacteriology, 1988-08, Vol.170 (8), p.3493-3498

1988

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Membrane permeation characteristics of 5'-modified thymidine analogs

Molecular pharmacology, 1992-05, Vol.41 (5), p.950-956

1992

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Three-dimensional structure of thymidine phosphorylase from Escherichia coli at 2.8 A resolution

The Journal of biological chemistry, 1990-08, Vol.265 (23), p.14016-14022

1990

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Varicella-Zoster virus thymidine kinase: Characterization and substrate specificity

Biochemical pharmacology, 1993-12, Vol.46 (12), p.2209-2218

1993

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Novel 6-alkoxypurine 2',3'-dideoxynucleosides as inhibitors of the cytopathic effect of the human immunodeficiency virus

Journal of medicinal chemistry, 1993-02, Vol.36 (3), p.378-384

1993

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Deoxycytidine kinase from calf thymus. Substrate and inhibitor specificity

The Journal of biological chemistry, 1976-07, Vol.251 (13), p.4055-4061

1976

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Enzyme-mediated enantioselective preparation of pure enantiomers of the antiviral agent 2',3'-dideoxy-5-fluoro-3'-thiacytidine (FTC) and related compounds

Journal of organic chemistry, 1992-10, Vol.57 (21), p.5563-5565

1992

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Crystallization and preliminary x-ray investigation of thymidine phosphorylase from Escherichia coli

The Journal of biological chemistry, 1987-03, Vol.262 (8), p.3788-3789

1987

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2-Ester Prodrugs of the Varicella-Zoster Antiviral Agent, 6-Methoxypurine Arabinoside

Antiviral chemistry & chemotherapy, 1992-12, Vol.3 (6), p.371-378

1992

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Design, Synthesis, and Antiviral Activity of α-Nucleosides: d- and l-Isomers of Lyxofuranosyl- and (5-Deoxylyxofuranosyl)benzimidazoles

Potent and Selective Inhibition of Human Cytomegalovirus Replication by 1263W94, a Benzimidazole l-Riboside with a Unique Mode of Action

Synthesis and Antiviral Evaluation of Halogenated β-d- and -l-Erythrofuranosylbenzimidazoles

Pharmacokinetics of the thymidine analog 2′-fluoro-5-methyl-1-β- d-arabinofuranosyluracil (FMAU) in tumor-bearing rats

Design of Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase with Improved Drug Resistance Properties. 2

Synthesis and Antiviral Activity of 2‘-Deoxy-4‘-thio Purine Nucleosides

Influence of stereochemistry on antiviral activities and resistance profiles of dideoxycytidine nucleosides

Preclinical and Toxicology Studies of 1263W94, a Potent and Selective Inhibitor of Human Cytomegalovirus Replication

Anti-human immunodeficiency virus synergism by zidovudine (3'-azidothymidine) and didanosine (dideoxyinosine) contrasts with their additive inhibition of normal human marrow progenitor cells

The crystal structure of Escherichia coli purine nucleoside phosphorylase: a comparison with the human enzyme reveals a conserved topology

6-Methoxypurine arabinoside as a selective and potent inhibitor of varicella-zoster virus

Metabolic disposition and pharmacokinetics of the antiviral agent 6-methoxypurine arabinoside in rats and monkeys

Imidazo[4,5-c]pyridines (3-deazapurines) and their nucleosides as immunosuppressive and antiinflammatory agents

6-N-substituted derivatives of adenine arabinoside as selective inhibitors of varicella-zoster virus

Metabolism and pharmacokinetics of the anti-varicella-zoster virus agent 6-dimethylaminopurine arabinoside

Crystallization and preliminary X-ray investigation of uridine phosphorylase from Escherichia coli

Purification and properties of inosine-guanosine phosphorylase from Escherichia coli K-12

Membrane permeation characteristics of 5'-modified thymidine analogs

Three-dimensional structure of thymidine phosphorylase from Escherichia coli at 2.8 A resolution

Varicella-Zoster virus thymidine kinase: Characterization and substrate specificity

Novel 6-alkoxypurine 2',3'-dideoxynucleosides as inhibitors of the cytopathic effect of the human immunodeficiency virus

Deoxycytidine kinase from calf thymus. Substrate and inhibitor specificity

Enzyme-mediated enantioselective preparation of pure enantiomers of the antiviral agent 2',3'-dideoxy-5-fluoro-3'-thiacytidine (FTC) and related compounds

Crystallization and preliminary x-ray investigation of thymidine phosphorylase from Escherichia coli

2-Ester Prodrugs of the Varicella-Zoster Antiviral Agent, 6-Methoxypurine Arabinoside

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