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Synthesis and Evaluation of in Vivo Anti-hypothermic Effect of the N- and C-Terminus Modified Thyrotropin-Releasing Hormone Mimetic: [(4S,5S)-(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-[3-(thiazol-4-yl)-L-alanyl]-L-prolinamide

Chemical and Pharmaceutical Bulletin, 2021/04/01, Vol.69(4), pp.314-324

2021

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Involvement of the Peripheral μ-Opioid Receptor in Tramadol-Induced Constipation in Rodents

Biological and Pharmaceutical Bulletin, 2021/11/01, Vol.44(11), pp.1746-1751

2021

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Efficacy of Naldemedine on Intestinal Hypomotility and Adhesions in Rodent Models of Postoperative Ileus

Biological and Pharmaceutical Bulletin, 2023/12/01, Vol.46(12), pp.1714-1719

2023

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Discovery of naldemedine: A potent and orally available opioid receptor antagonist for treatment of opioid-induced adverse effects

Bioorganic & medicinal chemistry letters, 2019-01, Vol.29 (1), p.73-77

2019

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Effects of Naldemedine: A Peripherally Acting Mu-Opioid Receptor Antagonist in Rat Models of Opioid-Induced Constipation: 1322

The American journal of gastroenterology, 2015-10, Vol.110, p.S578

2015

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Morphine, Oxycodone, and Fentanyl Exhibit Different Analgesic Profiles in Mouse Pain Models

Journal of Pharmacological Sciences, 2009, Vol.111(1), pp.60-72

2009

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Discovery of the Orally Effective Thyrotropin-Releasing Hormone Mimetic: 1‑{N‑[(4S,5S)‑(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-3-(thiazol-4-yl)‑l‑alanyl}-(2R)‑2-methylpyrrolidine Trihydrate (Rovatirelin Hydrate)

ACS omega, 2018-10, Vol.3 (10), p.13647-13666

2018

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Correction to Discovery of the Orally Effective Thyrotropin-Releasing Hormone Mimetic: 1‑{N‑[(4S,5S)‑(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-3-(thiazol-4-yl)‑l‑alanyl}-(2R)‑2-methylpyrrolidine Trihydrate (Rovatirelin Hydrate)

ACS omega, 2019-04, Vol.4 (4), p.6977-6978

2019

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Preventive effects of naldemedine, peripherally acting μ-opioid receptor antagonist, on morphine-induced nausea and vomiting in ferrets

Life sciences (1973), 2020-09, Vol.257, p.118048, Article 118048

2020

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Distinct Relations Among Plasma Concentrations Required for Different Pharmacological Effects in Oxycodone, Morphine, and Fentanyl

Journal of pain & palliative care pharmacotherapy, 2011-11, Vol.25 (4), p.318-334

2011

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Questionnaire survey of hospitals in Saitama Prefecture regarding the shortage of 99mTc-labeled radiopharmaceuticals and 99Mo/99mTc generators

Annals of nuclear medicine, 2010-05, Vol.24 (4), p.319-323

2010

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Pharmacologic effects of naldemedine, a peripherally acting μ‐opioid receptor antagonist, in in vitro and in vivo models of opioid‐induced constipation

Neurogastroenterology and motility, 2019-05, Vol.31 (5), p.e13563-n/a

2019

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Efficacy of Naldemedine on Intestinal Hypomotility and Adhesions in Rodent Models of Postoperative Ileus

Biological and Pharmaceutical Bulletin, 2023, pp.b23-00449

2023

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Pharmacological Profile of Naldemedine, a Peripheral Acting μ-Opioid Receptor Antagonist: Comparison With Naloxone and Naloxegol: 173

The American journal of gastroenterology, 2018-10, Vol.113 (Supplement), p.S96-S97

2018

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The antagonistic activity profile of naloxone in μ-opioid receptor agonist-induced psychological dependence

Neuroscience letters, 2020-09, Vol.735, p.135177-135177, Article 135177

2020

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Involvement of the Peripheral μ-Opioid Receptor in Tramadol-Induced Constipation in Rodents

Biological and Pharmaceutical Bulletin, 2021-11, Vol.44 (11), p.1746-1751

2021

Volltextzugriff (PDF)

Questionnaire Survey of SPECT Studies after the Supply Shortage of Tc-99m and Model Analysis Concerning Earnings and Expenditure of Generator Use

RADIOISOTOPES, 2012, Vol.61(12), pp.613-618

2012

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2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 3: Synthesis and activity of isosteric analogs

Bioorganic & medicinal chemistry, 2008-12, Vol.18 (24), p.6444-6447

2008

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Development of Electroformed Ni-Co-based Magnetic Polishing Tools

Transactions of the Japan Society of Mechanical Engineers Series C, 2007/02/25, Vol.73(726), pp.632-638

2007

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Effect of blending ratio of steel can pellets without cap on mechanical properties of spheroidal graphite cast iron

Chūzō kōgaku, 2009-06, Vol.81 (6), p.320-320

2009

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Effects of Blending Ratio of Can Cap Separated Steel Can Pellets on Mechanical Properties of Spheroidal Graphite Cast Iron

Journal of Japan Foundry Engineering Society, 2008/11/25, Vol.80(11), pp.619-623

2008

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2 -Arylimino -5,6 -dihydro -4H-1,3 -thiazines as a new class of cannabinoid receptor agonists. Part 2 Orally bioavailable compounds

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.3925-3929

2007

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Development of Magnetic Polishing Tools Using Electroforming

Transactions of the Japan Society of Mechanical Engineers Series C, 2005/11/25, Vol.71(711), pp.3326-3332

2005

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Questionnaire survey of hospitals in Saitama Prefecture regarding the shortage of super(99m)Tc-labeled radiopharmaceuticals and super(99)Mo/ super(99m)Tc generators

Annals of nuclear medicine, 2010-05, Vol.24 (4), p.319-323

2010

Volltextzugriff (PDF)

2-Arylimino-5,6-dihydro-4 H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 3: Synthesis and activity of isosteric analogs

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (24), p.6444-6447

2008

Volltextzugriff (PDF)

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Synthesis and Evaluation of in Vivo Anti-hypothermic Effect of the N- and C-Terminus Modified Thyrotropin-Releasing Hormone Mimetic: [(4S,5S)-(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-[3-(thiazol-4-yl)-L-alanyl]-L-prolinamide

Involvement of the Peripheral μ-Opioid Receptor in Tramadol-Induced Constipation in Rodents

Efficacy of Naldemedine on Intestinal Hypomotility and Adhesions in Rodent Models of Postoperative Ileus

Discovery of naldemedine: A potent and orally available opioid receptor antagonist for treatment of opioid-induced adverse effects

Effects of Naldemedine: A Peripherally Acting Mu-Opioid Receptor Antagonist in Rat Models of Opioid-Induced Constipation: 1322

Morphine, Oxycodone, and Fentanyl Exhibit Different Analgesic Profiles in Mouse Pain Models

Discovery of the Orally Effective Thyrotropin-Releasing Hormone Mimetic: 1‑{N‑[(4S,5S)‑(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-3-(thiazol-4-yl)‑l‑alanyl}-(2R)‑2-methylpyrrolidine Trihydrate (Rovatirelin Hydrate)

Correction to Discovery of the Orally Effective Thyrotropin-Releasing Hormone Mimetic: 1‑{N‑[(4S,5S)‑(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-3-(thiazol-4-yl)‑l‑alanyl}-(2R)‑2-methylpyrrolidine Trihydrate (Rovatirelin Hydrate)

Preventive effects of naldemedine, peripherally acting μ-opioid receptor antagonist, on morphine-induced nausea and vomiting in ferrets

Distinct Relations Among Plasma Concentrations Required for Different Pharmacological Effects in Oxycodone, Morphine, and Fentanyl

Questionnaire survey of hospitals in Saitama Prefecture regarding the shortage of 99mTc-labeled radiopharmaceuticals and 99Mo/99mTc generators

Pharmacologic effects of naldemedine, a peripherally acting μ‐opioid receptor antagonist, in in vitro and in vivo models of opioid‐induced constipation

Efficacy of Naldemedine on Intestinal Hypomotility and Adhesions in Rodent Models of Postoperative Ileus

Pharmacological Profile of Naldemedine, a Peripheral Acting μ-Opioid Receptor Antagonist: Comparison With Naloxone and Naloxegol: 173

The antagonistic activity profile of naloxone in μ-opioid receptor agonist-induced psychological dependence

Involvement of the Peripheral μ-Opioid Receptor in Tramadol-Induced Constipation in Rodents

Questionnaire Survey of SPECT Studies after the Supply Shortage of Tc-99m and Model Analysis Concerning Earnings and Expenditure of Generator Use

2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 3: Synthesis and activity of isosteric analogs

Development of Electroformed Ni-Co-based Magnetic Polishing Tools

Effect of blending ratio of steel can pellets without cap on mechanical properties of spheroidal graphite cast iron

Effects of Blending Ratio of Can Cap Separated Steel Can Pellets on Mechanical Properties of Spheroidal Graphite Cast Iron

2 -Arylimino -5,6 -dihydro -4H-1,3 -thiazines as a new class of cannabinoid receptor agonists. Part 2 Orally bioavailable compounds

Development of Magnetic Polishing Tools Using Electroforming

Questionnaire survey of hospitals in Saitama Prefecture regarding the shortage of super(99m)Tc-labeled radiopharmaceuticals and super(99)Mo/ super(99m)Tc generators

2-Arylimino-5,6-dihydro-4 H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 3: Synthesis and activity of isosteric analogs

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