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Development of subtype-selective oestrogen receptor-based therapeutics

Nature reviews. Drug discovery, 2011-10, Vol.10 (10), p.778-792

2011

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Reflections on the Discovery and Significance of Estrogen Receptor β

Endocrine reviews, 2005-05, Vol.26 (3), p.465-478

2005

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A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (4), p.701

2002

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Oestrogen Receptors and Selective Oestrogen Receptor Modulators: Molecular and Cellular Pharmacology

Basic & clinical pharmacology & toxicology, 2005-01, Vol.96 (1), p.15-25

2005

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Glucocorticoid Receptor Point Mutation V571M Facilitates Coactivator and Ligand Binding by Structural Rearrangement and Stabilization

Molecular endocrinology (Baltimore, Md.), 2005-08, Vol.19 (8), p.1960-1977

2005

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Synthesis of benzo-fused benzodiazepines employed as probes of the agonist pharmacophore of benzodiazepine receptors

Journal of medicinal chemistry, 1994-03, Vol.37 (6), p.745-757

1994

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Mouse Estrogen Receptor β Isoforms Exhibit Differences in Ligand Selectivity and Coactivator Recruitment

Biochemistry (Easton), 2005-06, Vol.44 (22), p.7936-7944

2005

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Thyroid Receptor Ligands. 3. Design and Synthesis of 3,5-Dihalo-4-alkoxyphenylalkanoic Acids as Indirect Antagonists of the Thyroid Hormone Receptor

Journal of medicinal chemistry, 2005-05, Vol.48 (9), p.3114-3117

2005

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Thyroid receptor ligands. Part 4: 4′-amido bioisosteric ligands selective for the thyroid hormone receptor beta

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (4), p.884-886

2006

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Thyroid receptor ligands. Part 5: Novel bicyclic agonist ligands selective for the thyroid hormone receptor β

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (5), p.1240-1244

2006

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Predictive binding of .beta.-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach

Journal of medicinal chemistry, 1992-10, Vol.35 (22), p.4001-4010

1992

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Abstract 705: Potentiation of immunotherapy by LSD1 modulation

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.705-705

2023

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New synthesis of .beta.-lactams based on nitrone cycloaddition to nitroalkenes

Journal of organic chemistry, 1984-01, Vol.49 (2), p.282-288

1984

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Synthetic and computer-assisted analyses of the pharmacophore for the benzodiazepine receptor inverse agonist site

Journal of medicinal chemistry, 1990-09, Vol.33 (9), p.2343-2357

1990

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Synthetic and computer-assisted analysis of the structural requirements for selective, high-affinity ligand binding to diazepam-insensitive benzodiazepine receptors

Journal of medicinal chemistry, 1993-06, Vol.36 (13), p.1820-1830

1993

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Functional Probing of the Human Glucocorticoid Receptor Steroid-interacting Surface by Site-directed Mutagenesis

The Journal of biological chemistry, 2000-06, Vol.275 (25), p.19041-19049

2000

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A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (4), p.701-704

2002

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Synthetic and computer assisted analysis of the pharmacophore for agonists at benzodiazepine receptors

Life sciences (1973), 1991, Vol.49 (3), p.207-216

1991

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Cycloaddition of nitrones with allenes. An example of steric control of regiochemistry

Journal of organic chemistry, 1987-08, Vol.52 (17), p.3909-3917

1987

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Regioselectivity associated with the 1,3-dipolar cycloaddition of nitrones with electron-deficient dipolarophiles

Journal of organic chemistry, 1984-01, Vol.49 (2), p.276-281

1984

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Reflections on the discovery and significance of estrogen receptor β: Recent progress in hormone research

Endocrine reviews, 2005, Vol.26 (3), p.465-478

2005

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Molecular Design Using the Minireceptor Concept

Journal of Chemical Information and Computer Sciences, 1997-07, Vol.37 (4), p.812-818

1997

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Functional probing of the human glucocorticoid receptor steroid-interacting surface by site-directed mutagenesis. Gln-642 plays an important role in steroid recognition and binding

The Journal of biological chemistry, 2000-06, Vol.275 (25), p.19041-19049

2000

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Intramolecular dipolar cycloaddition reactions of C-aryl oxaziridines

Heterocycles, 1986-03, Vol.24 (3), p.611-615

1986

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Solid-Phase Synthesis of a 6-Phenylquinolin-2(1H)-one Library Directed toward Nuclear Hormone Receptors

Journal of combinatorial chemistry, 2005-07, Vol.7 (4), p.567-573

2005

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Development of subtype-selective oestrogen receptor-based therapeutics

Reflections on the Discovery and Significance of Estrogen Receptor β

A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease

Oestrogen Receptors and Selective Oestrogen Receptor Modulators: Molecular and Cellular Pharmacology

Glucocorticoid Receptor Point Mutation V571M Facilitates Coactivator and Ligand Binding by Structural Rearrangement and Stabilization

Synthesis of benzo-fused benzodiazepines employed as probes of the agonist pharmacophore of benzodiazepine receptors

Mouse Estrogen Receptor β Isoforms Exhibit Differences in Ligand Selectivity and Coactivator Recruitment

Thyroid Receptor Ligands. 3. Design and Synthesis of 3,5-Dihalo-4-alkoxyphenylalkanoic Acids as Indirect Antagonists of the Thyroid Hormone Receptor

Thyroid receptor ligands. Part 4: 4′-amido bioisosteric ligands selective for the thyroid hormone receptor beta

Thyroid receptor ligands. Part 5: Novel bicyclic agonist ligands selective for the thyroid hormone receptor β

Predictive binding of .beta.-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach

Abstract 705: Potentiation of immunotherapy by LSD1 modulation

New synthesis of .beta.-lactams based on nitrone cycloaddition to nitroalkenes

Synthetic and computer-assisted analyses of the pharmacophore for the benzodiazepine receptor inverse agonist site

Synthetic and computer-assisted analysis of the structural requirements for selective, high-affinity ligand binding to diazepam-insensitive benzodiazepine receptors

Functional Probing of the Human Glucocorticoid Receptor Steroid-interacting Surface by Site-directed Mutagenesis

A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease

Synthetic and computer assisted analysis of the pharmacophore for agonists at benzodiazepine receptors

Cycloaddition of nitrones with allenes. An example of steric control of regiochemistry

Regioselectivity associated with the 1,3-dipolar cycloaddition of nitrones with electron-deficient dipolarophiles

Reflections on the discovery and significance of estrogen receptor β: Recent progress in hormone research

Molecular Design Using the Minireceptor Concept

Functional probing of the human glucocorticoid receptor steroid-interacting surface by site-directed mutagenesis. Gln-642 plays an important role in steroid recognition and binding

Intramolecular dipolar cycloaddition reactions of C-aryl oxaziridines

Solid-Phase Synthesis of a 6-Phenylquinolin-2(1H)-one Library Directed toward Nuclear Hormone Receptors

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