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Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors

Journal of medicinal chemistry, 1992-07, Vol.35 (14), p.2562-2572

1992

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Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Journal of medicinal chemistry, 1998-10, Vol.41 (22), p.4365-4377

1998

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Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype

Journal of medicinal chemistry, 1991-11, Vol.34 (11), p.3248-3260

1991

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Synthesis and structure-activity relationships of 9-substituted acridines as endothelin-A receptor antagonists

Bioorganic & medicinal chemistry letters, 1996-12, Vol.6 (24), p.2999-3002

1996

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2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity

Journal of medicinal chemistry, 1998-08, Vol.41 (17), p.3276-3292

1998

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Benzofuran derivatives as ET A-selective, non-peptide endothelin antagonists

European journal of medicinal chemistry, 1997, Vol.32 (5), p.425-431

1997

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In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor

The Journal of pharmacology and experimental therapeutics, 1997-12, Vol.283 (3), p.1433

1997

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Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: Implications for combination treatment with photodynamic therapy

Investigational new drugs, 1999-05, Vol.17 (2), p.121-135

1999

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Synthesis of Amino 1,3-Diols. Ring Opening of N-Acyl Activated Lactams with Carbon Nucleophiles

Synthetic communications, 1993-04, Vol.23 (7), p.971-983

1993

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Heterocyclic synthesis with β-ketosulfoxides IV. Synthesis of 3-substituted chromones

Journal of heterocyclic chemistry, 1974-04, Vol.11 (2), p.183-188

1974

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Reaction of enamines with o-hydroxy-.omega.-nitrostyrenes. Preparation of benzodihydropyans and hexahydroxanthenes and their rearrangement to pyrroline 1-oxides and hexahydroindole 1-oxides

Journal of organic chemistry, 1973-08, Vol.38 (17), p.3049-3051

1973

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Cyclization of 3-(o-hydroxyphenyl)hexahydroindole 1-oxides and 4-(o-hydroxyphenyl)pyrroline 1-oxides. Preparation of hydrobenzofuro[3,2-c]indoles and hydrobenzofuro[2,3-c]pyrroles

Journal of organic chemistry, 1973-08, Vol.38 (17), p.3012-3014

1973

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Reactions of carbanions of dimethyl sulfoxide and dimethyl sulfone with isocyanates, isothiocyanates, and other electrophilic reagents. Preparation of .beta.-amido and .beta.-thioamido sulfoxides and sulfones

Journal of organic chemistry, 1971-07, Vol.36 (13), p.1742-1744

1971

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Tetrahydroisoquinoline derivatives with AT2-specific angiotension II receptor binding inhibitory activity

Bioorganic & medicinal chemistry letters, 1994, Vol.4 (1), p.57-62

1994

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Derivatives of 5-[[1-4(4-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists

Journal of medicinal chemistry, 1995-09, Vol.38 (19), p.3759-3771

1995

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Stereospecific Synthesis of S,S-Statine and its Congeners

Synthetic communications, 1989-08, Vol.19 (13-14), p.2573-2583

1989

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Benzofuran derivatives as ETA-selective, non-peptide endothelin antagonists

European journal of medicinal chemistry, 1997-05, Vol.32 (5), p.425-431

1997

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Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation

Journal of medicinal chemistry, 1993-09, Vol.36 (18), p.2614-2620

1993

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Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types

Journal of medicinal chemistry, 1986-10, Vol.29 (10), p.1953-1961

1986

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4,5,6,7-Tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acids (spinacines)

Journal of heterocyclic chemistry, 1991-01, Vol.28 (1), p.97-108

1991

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General Rearrangement of 3-Substituted Chromones. Rearrangement to 1-Benzoxepins and 4-Chromanones

Synthesis (Stuttgart), 1977, Vol.1977 (1), p.61-63

1977

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Structure-function database for active site binding to the aspartic proteinases

Advances in experimental medicine and biology, 1991, Vol.306, p.143

1991

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Base rearrangement of chromone-3-carboxylic esters to 3-acyl-4-hydroxycoumarins

Journal of organic chemistry, 1974-08, Vol.39 (16), p.2436-2437

1974

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Synthesis and angiotensin-converting enzyme inhibitory activity of 3-(mercaptomethyl)-2-oxo-1-pyrrolidineacetic acids and 3-(mercaptomethyl)-2-oxo-1-piperidineacetic acids

Journal of medicinal chemistry, 1981-01, Vol.24 (1), p.104-109

1981

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ChemInform Abstract: Stereospecific Synthesis of S,S‐Statine and Its Congeners

ChemInform, 1990-04, Vol.21 (16), p.no-no

1990

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Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors

Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype

Synthesis and structure-activity relationships of 9-substituted acridines as endothelin-A receptor antagonists

2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity

Benzofuran derivatives as ET A-selective, non-peptide endothelin antagonists

In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor

Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: Implications for combination treatment with photodynamic therapy

Synthesis of Amino 1,3-Diols. Ring Opening of N-Acyl Activated Lactams with Carbon Nucleophiles

Heterocyclic synthesis with β-ketosulfoxides IV. Synthesis of 3-substituted chromones

Reaction of enamines with o-hydroxy-.omega.-nitrostyrenes. Preparation of benzodihydropyans and hexahydroxanthenes and their rearrangement to pyrroline 1-oxides and hexahydroindole 1-oxides

Cyclization of 3-(o-hydroxyphenyl)hexahydroindole 1-oxides and 4-(o-hydroxyphenyl)pyrroline 1-oxides. Preparation of hydrobenzofuro[3,2-c]indoles and hydrobenzofuro[2,3-c]pyrroles

Reactions of carbanions of dimethyl sulfoxide and dimethyl sulfone with isocyanates, isothiocyanates, and other electrophilic reagents. Preparation of .beta.-amido and .beta.-thioamido sulfoxides and sulfones

Tetrahydroisoquinoline derivatives with AT2-specific angiotension II receptor binding inhibitory activity

Derivatives of 5-[[1-4(4-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists

Stereospecific Synthesis of S,S-Statine and its Congeners

Benzofuran derivatives as ETA-selective, non-peptide endothelin antagonists

Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation

Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types

4,5,6,7-Tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acids (spinacines)

General Rearrangement of 3-Substituted Chromones. Rearrangement to 1-Benzoxepins and 4-Chromanones

Structure-function database for active site binding to the aspartic proteinases

Base rearrangement of chromone-3-carboxylic esters to 3-acyl-4-hydroxycoumarins

Synthesis and angiotensin-converting enzyme inhibitory activity of 3-(mercaptomethyl)-2-oxo-1-pyrrolidineacetic acids and 3-(mercaptomethyl)-2-oxo-1-piperidineacetic acids

ChemInform Abstract: Stereospecific Synthesis of S,S‐Statine and Its Congeners

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