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Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevance

Frontiers in genetics, 2013, Vol.4, p.24

2013

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MiR-155 and other microRNAs downregulate drug metabolizing cytochromes P450 in inflammation

Biochemical pharmacology, 2020-01, Vol.171, p.113725-113725, Article 113725

2020

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Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the "Missing Heritability" Problem

Frontiers in genetics, 2013, Vol.4, p.12

2013

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Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation

Analytical and bioanalytical chemistry, 2008-11, Vol.392 (6), p.1093-1108

2008

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Tri‐Allelic Haplotypes Determine and Differentiate Functionally Normal Allele CYP2D62 and Impaired Allele CYP2D641

Clinical pharmacology and therapeutics, 2021-05, Vol.109 (5), p.1256-1264

2021

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Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver

Hepatology (Baltimore, Md.), 2009-10, Vol.50 (4), p.1227-1240

2009

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Differential effects on human cytochromes P450 by CRISPR/Cas9-induced genetic knockout of cytochrome P450 reductase and cytochrome b5 in HepaRG cells

Scientific reports, 2021-01, Vol.11 (1), p.1000-1000, Article 1000

2021

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Role of Genetic and Nongenetic Factors for Fluorouracil Treatment-Related Severe Toxicity: A Prospective Clinical Trial by the German 5-FU Toxicity Study Group

Journal of clinical oncology, 2008-05, Vol.26 (13), p.2131-2138

2008

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Saturated Fat-Mediated Upregulation of IL-32 and CCL20 in Hepatocytes Contributes to Higher Expression of These Fibrosis-Driving Molecules in MASLD

International journal of molecular sciences, 2023-09, Vol.24 (17), p.13222

2023

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Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease

PloS one, 2011-08, Vol.6 (8), p.e23506-e23506

2011

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Sustainable implementation of antibiotic stewardship on a surgical intensive care unit evaluated over a 10-year period

Infection, 2020-02, Vol.48 (1), p.117-124

2020

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Aberrant splicing caused by single nucleotide polymorphism c.516G>T [Q172H], a marker of CYP2B66, is responsible for decreased expression and activity of CYP2B6 in liver

The Journal of pharmacology and experimental therapeutics, 2008-04, Vol.325 (1), p.284

2008

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Aortic valve calcification is subject to aortic stenosis severity and the underlying flow pattern

Heart and vessels, 2021-02, Vol.36 (2), p.242-251

2021

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Direct transcriptional regulation of human hepatic cytochrome P450 3A4 (CYP3A4) by peroxisome proliferator-activated receptor alpha (PPARα)

Molecular pharmacology, 2013-03, Vol.83 (3), p.709-718

2013

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Function and Localization Dynamics of Bifunctional Penicillin-Binding Proteins in Caulobacter crescentus

Journal of bacteriology, 2014-04, Vol.196 (8), p.1627-1639

2014

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Effects of Diminished NADPH:cytochrome P450 Reductase in Human Hepatocytes on Lipid and Bile Acid Homeostasis

Frontiers in pharmacology, 2021-11, Vol.12, p.769703-769703

2021

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Abundance of DNA adducts of methyleugenol, a rodent hepatocarcinogen, in human liver samples

Carcinogenesis (New York), 2013-05, Vol.34 (5), p.1025-1030

2013

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A New Panel-Based Next-Generation Sequencing Method for ADME Genes Reveals Novel Associations of Common and Rare Variants With Expression in a Human Liver Cohort

Frontiers in genetics, 2019, Vol.10, p.7-7

2019

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Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation

International journal of molecular sciences, 2022-07, Vol.23 (13), p.7468

2022

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Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance

Pharmacogenomics, 2007-07, Vol.8 (7), p.743-759

2007

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Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver

Drug metabolism and disposition, 2008-10, Vol.36 (10), p.2113

2008

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Interindividual variability of canalicular ATP‐binding‐cassette (ABC)–transporter expression in human liver

Hepatology (Baltimore, Md.), 2006-07, Vol.44 (1), p.62-74

2006

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Profiling induction of cytochrome p450 enzyme activity by statins using a new liquid chromatography-tandem mass spectrometry cocktail assay in human hepatocytes

Drug metabolism and disposition, 2010-09, Vol.38 (9), p.1589

2010

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Impact of CYP2B6 polymorphism on hepatic efavirenz metabolism in vitro

Pharmacogenomics, 2007-06, Vol.8 (6), p.547-558

2007

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Pharmacogenomics of human liver cytochrome P450 oxidoreductase: multifactorial analysis and impact on microsomal drug oxidation

Pharmacogenomics, 2009-04, Vol.10 (4), p.579-599

2009

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Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevance

MiR-155 and other microRNAs downregulate drug metabolizing cytochromes P450 in inflammation

Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the "Missing Heritability" Problem

Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation

Tri‐Allelic Haplotypes Determine and Differentiate Functionally Normal Allele CYP2D62 and Impaired Allele CYP2D641

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver

Differential effects on human cytochromes P450 by CRISPR/Cas9-induced genetic knockout of cytochrome P450 reductase and cytochrome b5 in HepaRG cells

Role of Genetic and Nongenetic Factors for Fluorouracil Treatment-Related Severe Toxicity: A Prospective Clinical Trial by the German 5-FU Toxicity Study Group

Saturated Fat-Mediated Upregulation of IL-32 and CCL20 in Hepatocytes Contributes to Higher Expression of These Fibrosis-Driving Molecules in MASLD

Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease

Sustainable implementation of antibiotic stewardship on a surgical intensive care unit evaluated over a 10-year period

Aberrant splicing caused by single nucleotide polymorphism c.516G>T [Q172H], a marker of CYP2B66, is responsible for decreased expression and activity of CYP2B6 in liver

Aortic valve calcification is subject to aortic stenosis severity and the underlying flow pattern

Direct transcriptional regulation of human hepatic cytochrome P450 3A4 (CYP3A4) by peroxisome proliferator-activated receptor alpha (PPARα)

Function and Localization Dynamics of Bifunctional Penicillin-Binding Proteins in Caulobacter crescentus

Effects of Diminished NADPH:cytochrome P450 Reductase in Human Hepatocytes on Lipid and Bile Acid Homeostasis

Abundance of DNA adducts of methyleugenol, a rodent hepatocarcinogen, in human liver samples

A New Panel-Based Next-Generation Sequencing Method for ADME Genes Reveals Novel Associations of Common and Rare Variants With Expression in a Human Liver Cohort

Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation

Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance

Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver

Interindividual variability of canalicular ATP‐binding‐cassette (ABC)–transporter expression in human liver

Profiling induction of cytochrome p450 enzyme activity by statins using a new liquid chromatography-tandem mass spectrometry cocktail assay in human hepatocytes

Impact of CYP2B6 polymorphism on hepatic efavirenz metabolism in vitro

Pharmacogenomics of human liver cytochrome P450 oxidoreductase: multifactorial analysis and impact on microsomal drug oxidation

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